Postdoc - methods for large-scale dynamic imaging of single cells
Sort on published: 2017-03-31
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 40,000 students, 7,000 employees and a turnover of SEK 6.5 billion.
The postdoc position is announced at the Department of Cell and Molecular Biology, SciLifeLab at Uppsala University. The department is one of the most international, interdisciplinary, and successful research departments in molecular life sciences in Europe.
The position is located in Johan Elf's research group where we make theoretical models of central processes in living cells and develop the methods needed to test these experimentally. The goal is to answer fundamental questions about the physical constraints for life at the molecular level, but also for example to show how variations in gene expression can contribute to the development of antibiotic resistance.
We are looking for a postdoctoral fellow who wants to work in a curiosity-driven interdisciplinary research team with world-leading research projects. We offer a stimulating research environment at the interface between biophysics, optics and microbiology.
This recruitment is part of a KAW funded project that aims to map the physical principles for how proteins search for specific sequences in the genome or transcriptome. The project is an interdisciplinary collaboration of researchers in biology, engineering and physics and you will work closely with several of these groups. The researchers involved are Maria Tenje and Helene Andersson-Svahn that work with microfluidic systems for cell analysis, Mats Nilsson that develops methods for molecular diagnostics in situ, Lynn Kamerlin who investigates of protein-DNA interactions using molecular dynamics simulations and Johan Elf, Magnus Johansson and Sebastian Deindl that investigate molecular interactions and kinetics using high resolution microscopy and single molecule FRET and structure based approaches.
Your specific project will make it possible to connect dynamic properties at the molecular level to the underlying genotype of thousands of cells simultaneously. In addition to filling an important gap in fundamental biological research, the method has potential applications for example drug discovery and optimization in biomolecule production.
You will lead the development of new methods to investigate the phenotypic variation in genetic strain libraries and link these to the underlying genotype. The technology is a based on combining microfluidics, advanced optical microscopy and methods for in situ genotyping that are already developed and used in the lab.
You have a PhD in a relevant area, a passion for science and an ambition to do research of high international quality. You have experience in methods development in microbiology, microscopy or microfluidics. Personal qualities such as the ability to lead and manage projects and at the same time be able to interact with other researchers is very important since a significant part of the research will be conducted in collaboration with colleagues from other disciplines. Excellent communication skills in written and spoken English are prerequisites.
An engineering background and experience working with microfluidic systems, advanced microscopy, biophysics and experimental physics.
The position is for one year with high probability of extension. Start date: 2017-11-01, or by agreement.
Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.
Pay: Individual salary
Starting: 2017-11-01 or as otherwise agreed.
Type of employment: Temporary position ending 2018-10-31
Working hours: 100 %
For further information about the position please contact
Irmeli Barkefors (firstname.lastname@example.org) or Johan Elf (email@example.com)
Your application should contain a cover letter (maximum one page), CV (maximum two pages) and academic transcripts.
Welcome to submit your application no later than September 30 2017, UFV-PA 2017/1051
Are you considering moving to Sweden to work at Uppsala University? If so, you will find much information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact the International Faculty and Staff Services at firstname.lastname@example.org.
We decline offers of recruitment and advertising help. We only accept the application the way described in the advertisement.
Placement: Department of Cell and Molecular Biology
Type of employment: Full time , Temporary position longer than 6 months
Pay: Fixed pay
Number of positions: 1
Working hours: 100%
County: Uppsala län
Per Sundman, Saco-rådet
Ellena Papaioannou, Seko 018-471 3315
Marie Ols, TCO/ST 018-471 2459
Number of reference: UFV-PA 2017/1051
Last application date: 2017-09-30