Sort on published: 2017-09-06
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 40,000 students, 7,000 employees and a turnover of SEK 6.5 billion.
The Department of immunology, genetics and pathology at Uppsala University (http://www.igp.uu.se) has a broad research profile with several strong research groups focused on Genomics, Cancer and Molecular Diagnostics. Research is presently conducted in the following areas: Medical and Clinical Genetics, Immunology, Pathology, Tumor Biology and Vascular Biology. Parts of the organization are also integrated with the departments for Clinical Genetics, Immunology and Pathology-Cythology at Akademiska sjukhuset, Uppsala. The department provides a well-developed infrastructure for advanced molecular sciences, including access to front-line technology as well as core facilities for cell analyses, DNA sequencing and genotyping. The Department has a yearly turnover of around 255 million SEK with a staff of around 340 people, 90 of these that are PhD-students. The department is partially integrated with the SciLifeLab. SciLifeLab (www.scilifelab.se) is a Swedish national center for molecular biosciences with focus on health and environmental research. The center combines frontline technical expertise with advanced knowledge of translational medicine and molecular bioscience. SciLifeLab is hosted by four Swedish universities (Karolinska Institutet, KTH Royal Institute of Technology, Stockholm University and Uppsala University) and collaborates with several other universities.
SciLifeLab invites applications for Postdoc positions in the groups of our SciLifeLab Faculty.
Lars Feuk and his research group (http://www.igp.uu.se/research/genetics_genomics/lars_feuk/?languageId=1) use different sequencing approaches to study genetic variation and gene expression. The studies are focused on identification of genetic variation and gene expression changes associated with intellectual disability and schizophrenia. Studies of intellectual disability are based on whole genome sequencing of patients and their parents. New mutations can then be identified and further evaluated using traditional molecular biology. This aspect of the research is performed in collaboration with clinical genetics Unit at Uppsala University Hospital.
Studies in schizophrenia are performed on brain tissue samples form patients in order to identify genes and pathways that are differentially expressed between patients and controls. The data is also used to further characterize specific types of RNA. These include circular RNAs (circRNA) that have recently been shown to be abundant in human cells. A project has now been initiated to focus specifically on methods and analyses to increase the understanding of circRNA and elucidate their role in disease.
Duties: The project is focused on investigating circular RNA, a relatively new form of transcript that has been to shown to be important for regulation of gene expression. As part of the project different methods for detection of circular RNA will be tested and evaluated and the association of circular RNA with disease will be investigated. Part of the project also includes evaluating the potential of circRNA as biomarkers. The position will primarily involve bioinformatic analyses of RNA and DNA sequencing data to identify and quantify circRNA, and investigate their correlation with genetic variation and linear transcript expression. The work may also include wet lab experiments to extract and enrich for circRNA. The ability to analyze and statistically evaluate large data sets will be important aspects of the work. The tasks include planning and implementation of projects, compilation and analysis of data, as well as the writing of manuscripts for publication. The work includes contribution to the writing of applications and assistance in supervision of PhD students and students, no more then 20%.
Requirements: PhD in the field of bioinformatics, biotechnology, genomics, biomedicine or similar. To be eligible to apply you must have a PhD completed within three years of the application deadline. If you received your PhD earlier but special circumstances exist you are also eligible to apply. In addition, documented experience of analysis of data from next-generation sequencing with significant knowledge about bioinformatics analysis tools and databases are required. Experience working in Unix/Linux, using R and writing scripts are required. Excellent interpersonal and communication skills are required as well as demonstrated experience in compiling and publishing scientific papers in related fields. As the field is developing rapidly, an individual with the ability to test, evaluate and adjust analyses is required.
Additional qualifications: Experience extracting and working with RNA would be useful. Particular emphasis will be placed on academic skills, good collaboration skills and ability to work independently. Great emphasis will be placed on personal suitability.
Application: The application should contain an application letter with the motivation to join the group, curriculum vitae and list of scientific publications of the candidate. The name and contact details of the PhD supervisor should also be included.
Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.
Pay: According to individual qualifications.
Starting date: As soon as possible.
Type of employment: general temporary employment of two years.
Working hours: 100%
For further information about the position please contact
Lars Feuk, 018-471 4827, firstname.lastname@example.org
You are welcome to submit your application no later than 2017-09-27. UFV-PA 2017/2907.
We decline offers of recruitment and advertising help. We only accept the application the way described in the advertisement.
Placement: Department of Immunology, Genetics and Pathology
Type of employment: Full time , Temporary position longer than 6 months
Pay: Fixed pay
Number of positions: 1
Working hours: 100%
County: Uppsala län
Ellena Papaioannou, Seko
Suzanne Borén Andersson, TCO/ST 018-471 6251
Per Sundman, Saco-rådet 018-471 1485
Number of reference: UFV-PA 2017/2907
Last application date: 2017-09-27