Post-doctoral researcher in biochemistry
Sort on published: 2017-12-19
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 42,000 students, 7,000 employees and a turnover of SEK 6.7 billion.
The Department of Chemistry – BMC is located at the Uppsala Biomedical Centre campus. It belongs to the Faculty of Science and Technology and conducts research in biochemistry, organic chemistry, analytical chemistry, and physical chemistry.
The research in biochemistry is focused on catalysis, molecular recognition, structure and dynamics of complex molecular systems, and relationships between the presence of biomolecules and synthetic chemical compounds with various disease states. It includes the design and synthesis of small organic molecules and biological macromolecules. Method and technology development is a particular strength, and the development of new biochemical, analytical and biophysical methods enables advanced studies of biological systems and their regulation, and how diseases can be diagnosed and treated. Scientists with expertise in biophysical methods of interaction analysis are responsible for a facility belonging to SciLifeLab, part of a national infrastructure for research in life science.
The creative and research-intense environment contributes to a broad knowledge-base as well as cutting-edge expertise. In addition, Uppsala University has a highly developed innovation office that gives support for commercialization and external collaboration. Read more here.
Uppsala University offers one of the country's best educations in chemistry, with strong links to world-leading research. The Department of Chemistry – BMC is responsible for the Bachelor and Master programs in Chemistry, and the Master of Science in Chemical Engineering, together with our colleagues in the Faculty of Science and Technology and in the Faculty of Pharmacy, and contributes extensively in many other education programs. A wide range of courses, excellent research connections, and extensive lab work characterizes the education. Read more here.
We are looking for a postdoctoral researcher in biochemistry, a temporary position for two years.
The research will be conducted in a project aiming to develop new therapeutic strategies based on the discovery of STINP – a stress-induced protein required for efficient virus growth. It is funded by the Knut and Alice Wallenberg Foundation and will be carried out in a team consisting of five research groups with complementary expertise, located at Uppsala and Stockholm Universities. The protein of interest is a nuclear RNA-binding zinc finger protein involved in export of mRNA. The specific goal for our lab is to develop and evaluate STINP function modulators and their therapeutic potential for treating viral infections and cancer.
Duties: The work will involve the recombinant production of STINP in a form suitable for biochemical and biophysical studies. This will be followed by development of SPR biosensor assays suitable for exploration of the interaction between STINP and a library of compounds, and their ability to interfere with specific STINP interactions with proteins or RNA. It will be used for the screening for small molecules that interfere with the specific STINP-protein or nucleic acid interactions identified by others in the project.
Qualifications: To be eligible to apply you must have a Ph.D. in biochemistry, or an exam judged to be comparable to a Swedish Ph.D. in biochemistry. It must have been completed within three years of the application deadline. If you received your PhD earlier but special circumstances, prolonged periods of illness, parental leave, military service, union duties and others of similar character, exist you are also eligible to apply.
Successful applicants must have a documented and broad competence in basic biochemical methodology. They need to have expertise in recombinant protein production, ideally with experience of culture of human and insect cells, as well as yeast and fungi, as a complement to bacterial cells. The ability to purify proteins in a highly pure and stable form, with and without tags and fusion proteins, is a core competence. Experience of producing proteins with post-translational modifications or modifying proteins after purification will be an asset. The applicant should have experience of a broad repertoire of methods for extensive characterisation of proteins using advanced biochemical, analytical and biophysical methods. In particular, this should include characterization of proteins and their interactions with other biomolecules or organic molecules of relevance for pharmaceutical research. A good understanding of the drug discovery process is required.
We emphasize the importance of personal suitability for this position. You need to be strongly motivated to carry out the work in the project. This project requires that you are able to work independently, while also having excellent collaborative skills. It requires that you are able to cooperate with scientists in other departments and universities. You must be very organized and systematic in your lab work, as well as reliable and disciplined with respect to lab management, ensuring that labs and instruments are kept clean and in good working order. As you will be expected to collaborate with other scientists, and contribute to project management on every level, you also need to have the skills necessary to ensure that the work environment is excellent. We expect you are proficient in oral and written English in order to be able to interact and communicate efficiently with collaborators, and publish internationally.
Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.
Salary: Individually negotiated salary.
Starting date: Will be agreed
Type of position: Temporary full-time position for two years.
For further information about the position please contact Helena Danielson, email@example.com
You are welcome to submit your application no later than 2018-01-09.
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We decline offers of recruitment and advertising help. We only accept the application the way described in the advertisement.
Placement: Department of Chemistry - BMC
Type of employment: Full time , Temporary position longer than 6 months
Pay: Fixed salary
Number of positions: 1
Working hours: 100%
County: Uppsala län
Ellena Papaioannou, Seko
Per Sundman, Saco-rådet 018-471 1485
Suzanne Borén Andersson, TCO/ST 018-471 6251
Number of reference: UFV-PA 2017/4704
Last application date: 2018-01-09