PhD Student in molecular pharmacology and toxicology
Sort on published: 2018-01-16
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 42,000 students, 7,000 employees and a turnover of SEK 6.7 billion.
The Department of Pharmacy offers a stimulating multidisciplinary working environment in research and teaching within the Pharmaceutical disciplines. The research is developed by a series of research groups, several of international prominence. Information about the Department of Pharmacy can be found at: www.farmfak.uu.se/farm/.
The PhD student will be linked to the research group in Drug Delivery at the Department of Pharmacy. The group takes a multidisciplinary approach and combines computational chemistry and bioinformatics with cell- and molecular biology, biopharmaceutics, and system pharmacokinetics and dynamics to find new ways to predict and define rate-limiting barriers to the absorption and cellular distribution of different types of drugs. More recently, the group has successfully explored the relationship between drug exposure, cellular target engagement and pharmacological effect. The PhD project will take advantage of these studies in order to explore the relationship between exposure to endocrine disrupting chemicals (EDCs) and toxicological outcome. Exposure to EDCs presents potential for serious human health risks and their risk assessment and regulation are currently of high priority globally. The project is supported by a PhD student grant from FORMAS. For information about the Drug Delivery research group, visit: http://www.farmfak.uu.se/farm/lmformul/.
The project is a collaboration with Swetox, which is an academic research center formed between 11 Swedish universities, created in order to further improve Sweden’s ability to meet society’s need for safe chemicals and a non-toxic environment. The hub of Swetox resides within the Karolinska Institute and is situated at the former AstraZeneca R+D site in Gärtuna, Södertälje. Swetox has a number of academic groups and a research infrastructure providing expertise and equipment in all areas of safety assessment of foreign chemicals, with particular focus on pharmaceuticals and EDCs. Information about Swetox can be found at www.swetox.se/en/research/ .
The project: The aim of the project is to provide models that better predict and reconcile the toxicological outcomes of EDCs. This will be achieved by exploring a previously unstudied parameter for these compounds, the intracellular (bio-active) bioavailability, which varies between different cell systems. The PhD student will study series of estrogenic EDCs in cell systems currently used to generate data for risk assessment. Biological factors potentially controlling the intracellular bioavailability, such as transport, metabolism, lipid content and EDC-binding proteins, will also be studied using state-of-the-art technologies such as thermal proteome profiling, proteomics and metabolomics. The PhD student will then integrate the data in new predictive QSAR and PBTK models describing the bio-kinetic behavior of these EDCs in relation to exposure. The aim is to normalize toxicity response differences, thus greatly contributing to risk assessment of these particular EDCs, other EDC chemistries and toxicants in general.
Qualifications: A Master of Science in the Pharmaceutical Sciences, Engineering, Cell biology, Bioinformatics, Toxicology or other relevant area is required. The ideal candidate is highly motivated, with a thorough education and strong interest in the research field. Previous laboratory experience with the experimental setups and techniques, and an interest in mathematical modelling and bioinformatics are beneficial. Candidates must be proficient in English and have good communication skills. The holder of a PhD-student position shall primarily devote her or his time to their own research studies. Other departmental work, such as educational or administrative, can constitute part of the position duties (max 20%). Information about postgraduate studies, including eligibility requirements and admission rules, can be found at http://www2.medfarm.uu.se/utbildning/forskarniva/ .
Conditions: The PhD program comprises four years of full-time study. In addition, departmental duties (teaching and other laboratory maintenance duties) may be included in the scope of the employment giving a period of 5 years. The salary is determined according to local guidelines at Uppsala University.
How to apply: The application should include a letter describing your research interests and motivation for PhD studies, a short description of your education, a CV, an authorized copy of your BSc/MSc degree(s), a copy of your master thesis and the names and contact information (address, email address, and phone number) of at least two reference persons, and relevant publications (including MSc thesis).
Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.
Salary: According to local agreement for PhD students and teaching assistants.
Starting date: March 1st or as agreed upon
For further information about the position, please contact
Professor Per Artursson, e-mail email@example.com, phone +46 (0) 70 4250888 (cell) or Professor Ian Cotgreave, e-mail firstname.lastname@example.org, phone +46 (0) 73 7121365 (cell)
Please submit your application by 5 February 2018, UFV-PA 2018/133.
Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at email@example.com.
Please do not send offers of recruitment or advertising services. Applications must be submitted as described in this advertisement.
Placement: Department of Pharmacy
Type of employment: Full time , Temporary position longer than 6 months
Number of positions: 1
Working hours: 100%
County: Uppsala län
Ellena Papaioannou, Seko
Per Sundman, Saco-rådet 018-471 1485
Suzanne Borén Andersson, TCO/ST 018-471 6251
Number of reference: UFV-PA 2018/133
Last application date: 2018-02-05