PhD position in Structural Biology
Sort on published: 2018-05-31
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 42,000 students, 7,000 employees and a turnover of SEK 6.7 billion.
The Department of Cell and Molecular Biology is one of the most international, broad and distinguished biomolecular departments in Europe, comprising six research programs with about 130 employees.
Molecular machines are proteins that convert chemical energy into conformational changes to carry out work in the cell. Our group studies the structural architectures and dynamics of molecular machines with a focus on nucleic-acid interacting enzymes whose aberrant function or dysregulation is often associated with severe disease states.
We use an innovative approach to characterize the dynamics and regulation of chromatin-associated protein machines. The PhD student will build on currently ongoing work to further investigate the mechanism and regulation of chromatin-associated proteins. This assignment comprises experimental design, structural determinations using mainly cryo-EM and functional studies with a focus on biochemistry. You are expected to carry out experiments independently but also to seek advise from the senior scientists in the Deindl group.
You have a passion for science and high ambitions to perform top quality research. You hold a Master’s degree in a relevant subject area, ideally molecular biology; you have very good knowledge in structural biology and you are proficient in protein expression and purification. You should be comfortable performing FPLC purification and gel electrophoresis and you should have experience with molecular cloning. Personal qualities, the ability to work independently and at the same time to be able to interact with other researchers is very important. Excellent communication skills in written and spoken English are prerequisites.
Experience with eukaryotic cell culture. Good knowledge of Image J and MATLAB.
Applications should include a brief description of research interests and relevant experience, a CV, copies of diplomas and certificates, thesis as well as other relevant documents that the applicant wishes to refer to.
Rules governing Ph.D. candidates are set out in the Higher Education Ordinance Chapter 5, §§ 1-7 and in Uppsala university's rules and guidelines http://regler.uu.se/search/?hits=30&languageId=1&search-language_en=English
Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.
Salary: According to local agreement for PhD students and teaching assistants.
Starting date: 01-08-2018, temporary full-time position ending 31-07-2022.
Please submit your application by 14-06-2018, UFV-PA 2018/2104
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Placement: Department of Cell and Molecular Biology
Type of employment: Full time , Temporary position longer than 6 months
Pay: Fixed salary
Number of positions: 1
Working hours: 100 %
County: Uppsala län
Ellena Papaioannou, Seko
Suzanne Borén Andersson, TCO/ST 018-471 6251
Per Sundman, Saco-rådet 018-471 1485
Number of reference: UFV-PA 2018/2104
Last application date: 2018-06-14