A PhD position in Neuroscience with focus on neuronal stem cells
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 44.000 students, 7.100 employees and a turnover of SEK 7 billion.
At the Department of Neuroscience, we are working hard to increase our knowledge and insights into this area as well as into large areas of our musculoskeletal system and its disorders. A major objective with our research is to develop novel strategies to prevent and treat diseases and injuries in the nervous system and musculoskeletal system. By participating in different educational programs and courses, scientists at the Department communicate their knowledge to a wide range of future professional specialists – for example nurses, physicians, physiotherapists, speech pathologists and biomedical researchers.
We are about 130 employees, 100 graduate students and numerous young postdoctoral fellows. Moreover, a large number of professionals carry out research and teaching at Uppsala University Hospital (Akademiska sjukhuset) within the framework of the Department’s activity. Basic research is predominantly carried out the Uppsala University Biomedical Center (BMC) and clinical research at various units in Akademiska sjukhuset.
Duties/Project description: Neurons do not normally divide. As a rule, they lose the capacity to divide during the process of differentiation at the time when they leave the progenitor state and become a neuron. This project studies how neurons in the retina are formed and particularly how their final cell division, which is also denoted the terminal mitosis, is regulated. We have shown that some cell types in the developing retina violate this standard “non-divide” rule and divide as an immature neuron. Interestingly, the very same cell types are prone to develop cancer: retinoblastoma. The project will study the regulation of neuronal stem and progenitor cells and in particular the properties that make the cells more susceptible for cell cycle aberration during the terminal mitosis. The project will include studies of developing human retina from retinal organoids, derived from embryonic stem cells or induced pluripotent stem cells. The project may also utilize animal models for the studies.
Requirements: Applicants must hold an academic degree equivalent to “Magister” in medicin, biomedicine, biology, pharmacy or equivalent. Good and documented theoretical knowledge in molecular-, cell- and tissue biology as well as developmental- and/or neurobiology is advantageous. Experience of eukaryotic cell culture, immunological analyses and gene expression analysis such as qRT-PCR or proteome and transcriptome analyses, is meriting. Experience of work with animals is also meriting. High motivation for doing research and capacity to work independently are important. The project involves collaborations and because we place great value in that all co-workers contribute to a good working environment, applicants must be able to cooperate well with colleagues and staff at the department. We value new ideas, and good applicants thus have a creative mind-set in order to find new approaches to the research problems we aim to solve. In order to interact and publish on an international arena we require applicants to be proficient English speakers and writers. Personal suitability will be a significant factor in the application process.
The PhD student is expected to carry out full time research training during the actual period in developmental neuroscience. The student will also be expected to take on departmental duties, such as equipment maintenance and teaching, to an extent corresponding to a maximum of 20% of the student’s employment time
- A personal letter with a brief description of yourself and your research interests. Two pages written in English
- CV with education, examina and other relevant merits including experience and techniques
- Copies of diploma and degrees, bachelor or master thesis, and other documents you wish to invoke. All copies should have certification for authenticity.
- Two references with full contact details. The relation of the applicant to the reference person should be indicated.
Rules governing Ph.D. candidates are set out in the Higher Education Ordinance Chapter 5, §§ 1-7 and in Uppsala university's rules and guidelines http://regler.uu.se/search/?hits=30&languageId=1&search-language_en=English
Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.
Salary: According to local agreement for PhD students and teaching assistants.
Starting date: 2018-Oct or as agreed
Type of position: Full time position.
For further information about the position please contact Head of Department, Finn Hallböök, 018-471 4949, firstname.lastname@example.org
Please submit your application by September 23rd 2018, UFV-PA 2018/2889.
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Please do not send offers of recruitment or advertising services. Applications must be submitted as described in this advertisement.
Placement: Department of Neuroscience
Type of employment: Full time , Temporary position longer than 6 months
Pay: Fixed salary
Number of positions: 1
Working hours: 100 %
County: Uppsala län
Ellena Papaioannou, Seko
Suzanne Borén Andersson, TCO/ST 018-471 6251
Per Sundman, Saco-rådet 018-471 1485
Number of reference: UFV-PA 2018/2889
Last application date: 2018-09-23
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