After completing the course, the student should be able to
describe basic toxicological principles and describe how different chemicals are taken up by, processed in and eliminated from the body
describe different the importance of different organs for detoxification/ toxification of chemicals, and describe mechanisms for chemically induced neurotoxicity and endocrine toxicity
describe different behaviour tests and their importance to discover of different neurological and endocrinological disturbances
describe when different chemicals are most toxic, and mechanisms behind the effects. Be able to discuss when and how different chemicals can interact under the development to induce effects
describe different genetic testing methods and injuries after various types of ionising radiation
apply different toxicological frameworks within the professional disciplines and have awareness about different risk assessment criteria
In the course, an introduction to Master's studies is included. After passing this module, the student should be able to
show awareness of ethical aspects of research and development including questions concerning plagiarism
demonstrate an understanding of the potential applications of biology, limitations and its role in society
take personal responsibility for acquiring knowledge.
General toxicological principles and overview of toxic substances: The part includes basic description how substances are absorbed by, distributed and eliminated from the body. The part contains awareness about toxicokinetic models and the processes of biotransformation.
Toxicity in specific target organs ? effects and mechanisms: The part includes basic toxicological knowledge of the effect of chemicals on central organs that are of significance for the uptakes/elimination and detoxification/toxification. Basic knowledge about how the communication systems of the body, the nervous system and the endocrine system is influenced of chemicals.
Behaviour toxicology: The part includes basic behaviour toxicological knowledge, how behavioural techniques can reveal chemicals that give functional disturbances
Development toxicology: The part includes basic knowledge of different developmental phases; embryonic and embryonic development, development during the neonatal period. Critical developmental phases then teratogenic injuries and functional disturbances are induced.
Genetic toxicology and ionising radiation: The part includes basic knowledge about genetic injuries and general genetic testing methods and mechanisms behind chemically induced injuries and injuries after ionising radiation.
Toxicology in the society: Environmental toxicology, food toxicology, clinical toxicology, epidemiology, risk assessment.
Lectures, group tuition, seminars and laboratory sessions. Attendance at the laboratory work and connected lessons is compulsory. . Students who participate in Introduction to Master Studies, perform a less extensive literature project. Participation in seminars , the literature assignment and laboratory sessions is compulsory.
Modules: Theory 8 credits; Laboratory session 4 credits; Literature assignment 1 credit and Introduction to Master Studies 2 credits, alternatively Literature assignment 3 credits The module theory is examined through written examination. The module laboratory sessions require implemented laboratory sessions and written laboratory reports. The module literature assignment requires written and oral presentation of literature assignment. For the Introduction to Master Studies active participation in seminars, a written report, and the completion of a study plan, are required.
This course can not be included, for the purposes of credits, with 1BG209 Toxicology.
week 27, 2017
Klaassen, Curtis D.;
Watkins, John B.;
Casarett, Louis J.
Casarett & Doull's essentials of toxicology