Master’s studies

Syllabus for Proteins and Drugs

Proteiner och läkemedel


  • 5 credits
  • Course code: 1KB423
  • Education cycle: First cycle
  • Main field(s) of study and in-depth level: Chemistry G2F, Biology G2F
  • Grading system: Fail (U), 3, 4, 5
  • Established: 2016-03-10
  • Established by: The Faculty Board of Science and Technology
  • Applies from: week 30, 2016
  • Entry requirements: One of the following is required: (1) 60 credits of which at least 40 credits in chemistry including 15 credits biochemistry and Structure and Function of Proteins, or (2) 60 credits of which at least 40 credits in biology, together with 15 credits in biochemistry and the Structure and Function of Proteins.
  • Responsible department: Department of Chemistry - BMC

Learning outcomes

After having complete course, the students are expected to be able to

  • describe how the properties of proteins relate to various disease processes
  • describe the mechanism of drugs directed against proteins
  • principally design a molecule that interferes with the normal function of a protein
  • experimentally identify and characterise molecules that interfere with the normal functions of proteins
  • produce and present a scientific poster


Examples and concepts: Projects defined by protein class, e.g. proteases. Projects by defined disease areas, e.g. cancer, antiviral drugs.
Pharmaceutical substances: Nature as a source for drugs. Rational drug design. Fragment based drug discovery.
Drug targets: Receptors, ion channels, enzymes, nucleic acids.
Biochemical methods for drug development: Target identification and characterisation. Lead identification and characterisation.
Lead optimisation: selectivity, resistance, ADME, pro-drugs.
From the pharmaceutical industry to the clinic.
Individual project: The mechanism of action for a given drug at the biochemical level has to be presented in form of a scientific poster.


The course is given in form of lectures and to a large extent in form of theoretical exercises and projects.
Exercises and projects are compulsory and are carried out individually.


Experimental and theoretical exercises and projects (2.5 credits) are examined during the course. An overall written examination (2.5 credits) is given at the end of the course. The final grade for the course is given as a weighted average grade for all compulsory parts.

Other directives

Cannot be included in a degree together with the course Proteins and drugs 5 credits (1KB404).

Reading list

Reading list

Applies from: week 11, 2016

Scientific articles and Internet resources for drug discovery.

  • Nelson, David L.; Cox, Michael M. Lehninger principles of biochemistry

    Seventh, international edition.: New York, NY: W.H. Freeman, [2017]

    Find in the library