After having completed the course the student should be able to :
describe the most commonly used biosensors today and their detection principles
explain how biosensors are used for different applications
compare different techniques regarding for example sensitivity and selectivity
describe and critically examine a selected application within the field of biosensors
propose a new type of biosensor for a given problem
Examples of how biosensors are used for different applications. Method validation. Protein/antibody-based sensors: protein immobilisation, specificity, binding constants, kinetics, diffusion. Electrochemical and optical sensors/transducers. Potentiometric methods. Redox-enzymes in amperometric methods. Conductimetric methods. Applications of the quartz microbalance. Optical methods: UV/Vis/IR, fluorescence, luminescence, fibre optics, surface plasmon resonance. Diagnostics and other biosensor applications are discussed critically with special emphasis on sensitivity, selectivity and stability.
Lectures, seminars, project, when possible study visit.
Written exam at the end of the course (3 credits). The project is assigned 2 credits and is examined both in a written and an oral form. The final grade is a weighted average of the results of the written exam and the project.
This course cannot be included in a degree together with the course 1KB650 Biosensors, 5 credits, or 1KB466 Biosensors, 5 credits.
week 08, 2017
Nelson, David L.;
Cox, Michael M.
Lehninger principles of biochemistry
Seventh, international edition.:
New York, NY: