The overriding the aim of this course is to provide basic knowledge in the interface between chemistry, physics and biology on the nanostructural level with a focus on biotechnological usage. The student should be able to on completion of the course:
account for interaction of biomolecules with surfaces of different chemical and physical species.
account for production and the applications of various types of nanostructured materials.
suggest methods for the design of enzyme reactors and other bioconjugates on surfaces and second carriers, and explain the carrier's influence on the activity of the biomolecule.
give examples of/analyse applications within the field of bioelectronics and account for the basic principles they are based on.
use basic principles of microfluidics to solve biotechnical and bioanalytical problems
make a risk assessment of a nanobiotechnological project.
Examples and production of various types of nanostructured materials with usage and potential within biotechnology. Using biomaterials and biomolecules as bases for inorganic structures. Introduction to surface physics and biomaterials. Methods for derivatisation and characterisation of surfaces and other carrying structures. Theory and methods for studies of the interaction with surfaces and fibres of biomolecules. Applications within bioseparation, diagnostics, the drug delivery and bioimplants. Theory for how lipid/polymer nanoparticles can be utilised as model membranes and for formulation/administration of drugs. Molecular prints of biomolecules. Production and applications of inorganic replicas of biological materials. Enzyme reactors based on nanostructured materials. During the course opportunities are given for oral and written reports.
Written examination is organised during the course and/or at the end of the course. Written examination correspond 6 credits, laboratory sessions and seminar exercises correspond 4 credits. The final grade corresponds to a joining of the written examination and the compulsory parts.