After successful completion of the course, the participant should have the ability to:
Account for the different interactions that are important for the formation of structures in biological systems and for how thermodynamic parameters can be measured.
Account for basic concepts within statistical thermodynamics and apply this to biological systems, macromolecules in solution, conformational equilibria, membrane equilibria, ligand binding and cooperativity.
Account for structures and functions of biological membranes, as well as model systems and relevant methods for the study of these structures and functions.
Explain and apply methods for the determination of functional molecular mass of biological macromolecules in solution as well as determination of equilibrium - and rate constants for macromolecule-ligand interactions.
Account for and apply spectroscopic methods for the study of structures and functions in biological systems
The structure of biological macromolecules. Statistical thermodynamics especially applied on biological systems, macromolecules in solution, conformational equilibria, membrane equilibria, ligand binding and cooperativity. Microcalorimetry. Methods to study equilibrium and speed for association-dissociation processes. Membrane proteins and membrane transport. Spectroscopic methods: UV-Vis and fluorescence, EPR, ESR and NMR related to biochemistry. Physical methods for studies of the interaction between biological macromolecules. Transport processes with relevance in biological systems and experimental biochemistry. Determination of functional molecular mass in solution using scattering methods and sedimentation
The teaching is given as lectures, lessons, seminars, laboratory sessions and projects with presentations. Communication training and profile according to chosen specialisation integrated with other course parts.
Written tests are organised at the end of the course and/or during the course and correspond to 6 credits. The laboratory sessions correspond to 4 .
week 34, 2012
Van Holde, Kensal Edward;
Johnson, W. Curtis;
Ho, Pui Shing
Principles of physical biochemistry