Syllabus for Knowledge-Based Systems in Bioinformatics

Kunskapsbaserade system inom bioinformatik

Syllabus

  • 5 credits
  • Course code: 1MB416
  • Education cycle: Second cycle
  • Main field(s) of study and in-depth level: Technology A1N, Bioinformatics A1N
  • Grading system: Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
  • Established: 2010-03-16
  • Established by:
  • Revised: 2018-10-30
  • Revised by: The Faculty Board of Science and Technology
  • Applies from: week 27, 2019
  • Entry requirements: Alt. 1. 120 credits including Genomics and Bioinformatics, Probability and Statistics, and Programming Techniques II.
    Alt. 2. 120 credits including Introduction to Bioinformatics, Introduction to Programming, Scientific Computing and Statistics, and Programming in Python.
    Alt. 3. 120 credits including 30 credits mathematics and 30 credits computer science. Introduction to Bioinformatics, and Script Programming.
  • Responsible department: Biology Education Centre

Learning outcomes

The course aims to provide a good understanding how logic-based methods can be applied in the construction of knowledge-based systems within Life Sciences. The flood of large and very large data sets such as gene expressions, molecular interactions and taxonomies requires efficient handling. Specifically, the course leads to an advanced understanding of how learning methods can be applied to solve several bioinformatics problems.

On completion of the course, the student should be able to

  • use and describe definitions and mathematical notation for information and decision systems, rough sets and rule systems
  • use other methods for machine learning such as clustering, decision trees, and relate them to rough sets
  • apply knowledge of rule-based systems and Monte Carlo-based selection methods to formulate and solve classification problems in Life Sciences

Content

Introduction to Boolean functions. Transformation and simplification of Boolean expressions. Information, decision systems and rough sets. Features and their  synthesis and selection. Training and validation of models. Statistical properties of models. Examples of applications inLifeSciences include: classification of expressions , prediction of gene functions from time profiles and genomic databases, modelling of transcriptional mechanisms, ligand receptor bindings, drug resistance, prediction of protein function from structure and modelling with clinical and genomic data. Lectures are interspaced with computer labs using real and synthetic data. Ontologies. Machine learning: clustering, rough sets, decision trees, Monte Carlo-based selection, statistical model validity and significance.

Instruction

Lectures, computer exercises, project and problem solving exercises.

Assessment

Written closed-book exam at the end of the course (3 credits). Written and computer exercises (1 credit).Project (1 credit).

Reading list

Reading list

Applies from: week 27, 2019