Sort on published: 2017-10-23
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 44.000 students, 7.100 employees and a turnover of SEK 7 billion.
The Department of Immunology, Genetics and Pathology at Uppsala University (http://www.igp.uu.se) has a broad research profile with several strong research groups focused on Genomics, Cancer and Molecular Diagnostics. Research is presently conducted in the following areas: Medical and Clinical Genetics, Immunology, Pathology, Tumor Biology and Vascular Biology. Parts of the organization are also integrated with the departments for Clinical Genetics, Immunology and Pathology-Cythology at Akademiska sjukhuset, Uppsala. The department provides a well-developed infrastructure for advanced molecular sciences, including access to front-line technology as well as core facilities for cell analyses, DNA sequencing and genotyping. The Department has a yearly turnover of around 340 million SEK with a staff of around 340 people, 120 of which are PhD-students.
We are seeking a highly motivated postdoc for experimental work in a cross-disciplinary team utilizing the power of large scale technologies to explore the biology of brain tumors. In the project, single cells will be isolated from glioma tumors and subjected to RNA sequencing to identify molecular markers of proliferation and invasion and to predict targets for evaluation of new glioblastoma therapeutic options. Genome editing and organotypic cultures will enable evaluation of genes that contribute to tumor invasiveness and drug sensitivity of glioblastoma cells. Following initial in vitro evaluation in our glioblastoma cell cultures targeted interventions will be evaluated in a preclinical in vivo study. The work is based on a very large in-house biobank of cells established from tumor surgical samples. In the project, you will work independently, and interact with experts in cancer research, drug development and computational biology. Key tasks are to develop methodology for single cell RNA sequencing and genome editing methods for glioblastoma cells and apply these tools for in vitro and in vivo studies, co-author papers, and participate in other academic tasks, e.g. presentation of results, writing proposals and report to funding organizations. Part of the work will be conducted at facilities for high-throughput sequencing. The applicant should have advanced experience in cell biology and experience from experimental animal models and molecular biology techniques for gene perturbation experiments, such as inducible shRNA or CRISPR techniques.
* Doctoral degree in a relevant area, e.g. biomedicine, biotechnology, pharmacology or medicine
* Documented experience of molecular biological experimental work, including gene perturbations and cell based assays
* Documented experience of working in cross-disciplinary teams that bridge molecular biology or cell biology experimental research and bioinformatics
* Deep knowledge in either of i) cell biology, ii) oncology, iii) pharmacology
* Documented experience of animal tumor models, FELASA category B certification or equivalent
* Documented experience of cancer biology, cancer genetics, or neurooncology
* Documented experience of cancer stem cell models
* Experience of single cell isolation, flow cytometry, organotypic cultures, immunohistochemistry, imaging, RNA sequencing, or CRISPR
Your application should comprise a CV, copies of degrees and relevant study transcripts and grades, publications and a short description of your research interests. We request that you provide references and preferably provide one or more letters of recommendation. The applications are assessed according to these criteria: basic training, prior experience in related areas, qualifications as above and personal qualities. Salary is set following local guidelines at Uppsala University. The University is an equal opportunity employer. Salary is set according to competence, you may mention your requested salary in the application.
Pay: According to individual qualifications
Type of employment: general temporary employment of two years
Working hours: 100%
For further information about the position please contact
Sven Nelander, 018-471 4805, mailto:firstname.lastname@example.org
You are welcome to submit your application no later than December 31, 2017. UFV-PA 2017/3502.
Please do not send offers of recruitment or advertising services. Applications must be submitted as described in this advertisement.
Placement: Department of Immunology, Genetics and Pathology
Type of employment: Full time , Temporary position longer than 6 months
Pay: Fixed pay
Number of positions: 1
Working hours: 100%
County: Uppsala län
Per Sundman, Saco-rådet
Ellena Papaioannou, Seko 018-471 3315
Suzanne Borén Andersson, TCO/ST 018-471 6251
Number of reference: UFV-PA 2017/3502
Last application date: 2017-12-31
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