Researcher in population genomics of dogs
Sort on published: 2018-01-17
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 42,000 students, 7,000 employees and a turnover of SEK 6.7 billion.
Project description: Thanks to the rapid and recent changes accompanying domestication, comparisons of wild and domestic life forms represent an ideal system for characterizing the genetic basis of phenotypic diversity. Based on whole genome sequencing we recently compared patterns of genetic variation in dog and wolf to provide an initial understanding of the genetic basis of adaptations during dog domestication. We found that selection had targeted the entire pathway responsible for starch digestion and glucose absorption in the small intestine of dogs, indicating that a shift from a meat based to a starch rich diet constituted a crucial step during the domestication process. Combined with evidence that this change was accompanied by selection for mutations that also affected the ability to store glucose as fat, these findings argue that dogs underwent a general shift from a protein to a more carbohydrate based energy metabolism. Dog domestication may thus represent a unique and unexplored natural model for studying metabolism arguing that a detailed characterization of the genetic basis of adaptations during dog domestication represents a novel perspective on the molecular components of nutrient absorption and carbohydrate and lipid metabolism. To benefit from this new perspective and to understand how dogs coped with the fundamental changes associated with the agricultural revolution this project combines large scale population genomic analyses, transcriptomics and analyses of existing comparative genetics resources to localize mutations that are likely to underlie metabolic adaptations in dog, followed by physiological experiments in genetically modified cell lines to test the effect of the indicated genes on metabolic processes.
Job description: Research in the project described above. The successful applicant will mainly analyse population scale whole genome resequencing data and transcriptome data.
Qualifications: To be eligible to apply you must have a Ph.D. in evolutionary biology, population genetics, genomics, bioinformatics or another relevant field.
The position requires documented experience in large-scale next-generation DNA sequencing analysis and the ideal candidate is highly motivated with a strong background in statistical, quantitative or population genetics. Candidates must have good communication skills, both in written and spoken English. Programming skills are desirable. We will put great emphasis on your personal qualities and interpersonal skills such as ability for collaborative work and flexibility.
Application: The application should include 1) A letter of intent describing yourself, your research background and interests, and why you would be suitable for the position (max 2 pages). 2) Your CV and publication list. 3) The names and contact information to at least two reference persons (email address and phone no.). 4) A copy of your PhD certificate, 5) Any unpublished work that you would like to present in support of your application. The application must be written in English.
Uppsala University finds that gender balance and diversity brings a higher quality to the organization. We therefore welcome applicants of any gender and with different birth background, functionality and life experience.
Pay: Individual salaries
Starting: As soon as possible for a period of one year with eventual possibility to extension.
Type of employment: Temporary position.
Working hours: 100 %
For further information about the position please contact
Erik Axelsson, firstname.lastname@example.org
You are welcome to submit your application no later than Febuary 15, 2018, UFV-PA 2018/103.
We decline offers of recruitment and advertising help. We only accept the application the way described in the advertisement.
Placement: Department of Medical Biochemistry and Microbiology
Type of employment: Full time , Temporary position longer than 6 months
Pay: Fixed salary
Number of positions: 1
Working hours: 100%
County: Uppsala län
Per Sundman, Saco-rådet
+46 18 471 1485
Suzanne Borén Andersson, TCO/ST +46 18 471 6251
Ellena Papaioannou, Seko +46 18 471 3315
Number of reference: UFV-PA 2018/103
Last application date: 2018-02-15