Researcher in therapy and diagnosis of neurodegenerative disease
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 44.000 students, 7.100 employees and a turnover of SEK 7 billion.
Research group: The research group of Molecular Geriatrics is located at the Rudbeck Laboratory and is closely linked to the memory clinic at the Uppsala University Hospital. Our research is focused on treatment and diagnosis of neurodegenerative diseases. The research is conducted in collaboration with other research groups internationally and in Sweden, as well as with various pharmaceutical companies.
Project description: Biologics make up a large part of newly developed drugs and are also increasingly used in in vivo diagnostics. This is also true for neurodegenerative diseases, where immunotherapy with monoclonal antibodies is one of the main strategies for treatment of Alzheimer’s and Parkinson’s disease. This development is hampered by the blood-brain barrier, which hinders protein based drugs to reach the brain. The research group has therefore developed a concept for receptor mediated transcytosis of bispecific antibodies, which markedly increases their brain uptake, with the aim to use them for immunotherapy and in vivo diagnostics with positron emission tomography (PET). The over-all objective of the current project is to study and further develop the concept to gain a deeper understanding of the immunological and pharmacological mechanisms of the bispecific antibodies and to improve their properties for immunotherapy and PET diagnostics. The project will involve planning and execution of in vivo experiment as well as analyses using different imaging techniques, histology, biochemistry and immunological methods.
Duties: We are looking for a highly motivated, independent and enthusiastic researcher who is expected to be active in leading and developing the project, to supervise students and to apply for research funding. The work will mainly be carried out at the Rudbeck Laboratory, Uppsala University.
Qualifications required: A doctoral degree in neurobiology, immunology, pharmacology, biochemistry/biotechnology as well as relevant postdoctoral research merits, preferably within the same area of research, is required. Experience from independent in vivo work is a demand and the applicant is expected to master immunological methods (FACS, immunostainings, ELISA) as well as different microscopy techniques. The applicant must have a good knowledge of written and spoken English.
Additional qualifications: Experience with cell culture, protein production and analyses, protein modifications, radiolabeling and medical imaging techniques is a merit. Documented experience with project leading and supervision of students is a merit.
Application: The application must contain a cover letter describing the applicant’s background and research interests, an updated CV including a list of previous publications, as well as copies of diplomas and certificates of higher academic degrees. Please also attach contact details (name, e-mail, phone number) to two referees.
Selection Process: Selection of candidates is based on qualifications, previous research experience within the field of research, and personal suitability.
Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.
Salary: Is set according to competence.
Starting date: As soon as possible or as otherwise agreed.
Type of employment: Temporary position for two years.
Scope of employment: 100 %
For further information about the position please contact: Associate professors Dag Sehlin (firstname.lastname@example.org) and Stina Syvänen (email@example.com)
Please submit your application by December 13th, 2019, UFV-PA 2019/3041.
Please do not send offers of recruitment or advertising services. Applications must be submitted as described in this advertisement.
Placement: Department of Public Health and Caring Sciences
Type of employment: Full time , Temporary position longer than 6 months
Number of positions: 1
Working hours: 100%
County: Uppsala län
Number of reference: UFV-PA 2019/3941
Last application date: 2019-12-13
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