Researcher

Published: 2022-04-28

The deadline for applying to this position has passed.

The Department of Immunology, Genetics and Pathology at Uppsala University has a broad research profile with strong research groups focused on cancer, autoimmune and genetic diseases. A fundamental idea at the department is to stimulate translational research and thereby closer interactions between medical research and health care. Research is presently conducted in the following areas: medical and clinical genetics, clinical immunology, pathology, neuro-oncology, vascular biology, radiation science and molecular tools. Department activities are also integrated with the units for Oncology, Clinical Genetics, Clinical Immunology, Clinical Pathology, and Hospital Physics at Akademiska sjukhuset, Uppsala. The department has teaching assignments in several education programmes, including Master Programmes, at the Faculty of Medicine, and in a number of educations at the Disciplinary Domain of Science and Technology. The department has a yearly turnover of around SEK 500 million, out of which more than half is made up of external funding. The staff amounts to approximately 345 employees, out of which 100 are PhD-students, and there are in total more than 700 affiliated people. Feel free to read more about the department's activities here: www.igp.uu.se

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Duties
Development of targeted radionuclide therapy using engineered scaffold proteins (affibody molecules, ADAPTs and DARPins). The methodology includes both direct targeting and pretargeting. The work includes development of labelling  chemistry of proteins and peptide nucleic acids with beta-emitting radionuclides, evaluation of the labelled constructs in vitro (stability, binding specificity, affinity, and cellular processing) and in vivo (biodistribution, targeting specificity, radionuclide imaging, dosimetry, experimental therapy). Work might include a supervision of MSc and PhD students.

Requirements
PhD degree in medical sciences or radiopharmacy with specialization in development of targeted radiopharmaceutics. MSc in organic chemistry or biotechnology. FELASA C certificate is a requirement.

Additional qualifications
Documented experience in work with radiolabelled scaffold proteins (labelling chemistry, in vitro and in vivo studies), as well as experience in development of pretargeting systems are very strong merits

About the employment
The employment is a temporary position, 5 months. Scope of employment 20 %. Starting date as agreed. Placement: Uppsala.

For further information about the position, please contact: Vladimir Tolmachev, vladimir.tolmachev@igp.uu.se, 018-471 3414.

Please submit your application by 16 May 2022, UFV-PA 2022/1525.

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