Researcher in Molecular Biophysics
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The Department of Cell and Molecular Biology is organized into seven research programmes which all focus on different areas of cell and molecular biology: Computational Biology and Bioinformatics, Microbiology and Immunology, Molecular Biology, Molecular Biophysics, Molecular Evolution, Molecular Systems Biology and Structural Biology. The scientific basis of what we do lies in biology, but our research overlaps with other areas such as medicine, computer science, mathematics, chemistry, engineering sciences and physics. In total, we are over 200 staff and ~60 Ph.D. students. Please read more about the department’s work at https://icm.uu.se.
Project description: Detecting the atomic structure of biomolecules is the basis for understanding biological function at the molecular level. This knowledge has led to enormous scientific advances, important drugs, and disruptive technologies. Structural methods exist, but many biomolecules have escaped structure determination; structural changes due to interactions cannot be easily characterized, and enzymatic mechanisms are hard to detect due to an insufficient time-resolution.
The project will develop fluctuation correlation X-ray scattering (FXS) with powerful X-ray free-electron lasers (XFEL), capable of producing extremely intense and ultra-short X-ray pulses radiation, which promises to determine the structure of biomolecules in biologically native conditions with light-triggered pump/probe experiments. The method is a natural extension of traditional small-angle X-ray scattering (SAXS). It has been demonstrated in 1977 by Kam for macroscopic objects based on scattering by visible light. Recent reports indicate that it is in principle possible to determine the structure of proteins in solution with FXS. If successful, this project will establish FXS as a new method for structure determination of biomolecules in native, ‘biological‘, conditions.
The applicant is expected to drive multiple ambitious projects within the area. The position involves carrying out FXS experiments on biological samples at leading XFELs along with all the associated preparation and analysis of the resulting data. The project aims to build up a new experimental setup, the position therefore also involves work on designing and developing this new setup.
Oral presentation and writing/editing of scientific papers and grant applications are part of the position.
We are looking for highly-motivated applicants with a PhD degree in a physics, biophysics or similar. The candidate is expected to be able to work independently and to have a strong interest in coherent X-ray imaging and method development. In addition, the candidate is expected to take own initiatives as well as to collaborate with colleagues both within and outside of the research group. The position is in an international context so good oral and written communication skills in English are essential. Finally, significant weight will be given to personal suitability such as; analytical and organizational skills, personal maturity, ability to work with others, take initiatives, and to show good judgement.
- Documented experience with X-ray experiments at XFELs.
- Documented experience with 3D printed nozzles for ultrathin liquid sheets.
- Documented experience with fluctuation X-ray scattering (FXS) is an advantage.
About the employment
The employment is a permanent position, probationary period may be applied. Scope of employment 100 %. Starting date as agreed. Placement: Uppsala
For further information about the position, please contact: Filipe Maia, 0704250171, firstname.lastname@example.org
Please submit your application by 15 February 2023, UFV-PA 2023/77.
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Placement: Department of Cell and Molecular Biology
Type of employment: Full time , Permanent position
Pay: Individual salary
Number of positions: 1
Working hours: 100%
County: Uppsala län
Number of reference: UFV-PA 2023/77
Last application date: 2023-02-15
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