Genomic and Epigenomic Medicine, 15 credits
Academic year 2022/2023
Course code: 3MG025
Spring 2023, 100%, Campus
Start date: 16 January 2023
End date: 19 March 2023
Language of instruction: English
Registration: Please contact the department.
Entry requirements: 180 credits in biology, bio-/medicine, biotechnology, pharmaceutical biosciences, medical science or equivalent education giving relevant knowledge in cell biology, genetics biochemistry and molecular biology. Proficiency in English equivalent to the Swedish upper secondary course English 6.
About the course
The course will provide an insight into the applications, strategies and implications of the genomic and epigenomic analysis of the human genome, its impact on human diseases and translation into clinical tools. Current opinions and research findings, as well as methods and technologies, will be conveyed and discussed throughout the course. Applications of bioinformatics and computational data analysis will be illustrated.
Genomic structure and variation will be covered as well as population genetics, discussing the HapMap and 1000 genomes projects. The identification of genetic causes and their associations to human diseases will be treated together with genetic epidemiology. The human transcriptome, its regulation, biogenesis and function will be treated. Comparative genomics will illustrate the genetic evolution of man and the use of animal or other model organisms in understanding human diseases.
Epigenomics comprise an in-depth account of the epigenetic mechanisms affecting chromatin structures such as modification of histones and DNA, non-coding RNAs and nuclear structure and their importance in different fundamental biological processes, as shown e.g. in the ENCODE project. Translational genomics will be illustrated by pharmacogenomics/epigenomics, its application in drug therapies of different diseases and its impact on public health and personalised medicine.