Syllabus for Molecular Cell Biology

Molekylär cellbiologi

A revised version of the syllabus is available.

  • 15 credits
  • Course code: 1BG320
  • Education cycle: Second cycle
  • Main field(s) of study and in-depth level: Biology A1N

    Explanation of codes

    The code indicates the education cycle and in-depth level of the course in relation to other courses within the same main field of study according to the requirements for general degrees:

    First cycle
    G1N: has only upper-secondary level entry requirements
    G1F: has less than 60 credits in first-cycle course/s as entry requirements
    G1E: contains specially designed degree project for Higher Education Diploma
    G2F: has at least 60 credits in first-cycle course/s as entry requirements
    G2E: has at least 60 credits in first-cycle course/s as entry requirements, contains degree project for Bachelor of Arts/Bachelor of Science
    GXX: in-depth level of the course cannot be classified.

    Second cycle
    A1N: has only first-cycle course/s as entry requirements
    A1F: has second-cycle course/s as entry requirements
    A1E: contains degree project for Master of Arts/Master of Science (60 credits)
    A2E: contains degree project for Master of Arts/Master of Science (120 credits)
    AXX: in-depth level of the course cannot be classified.

  • Grading system: Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
  • Established: 2007-03-15
  • Established by: The Faculty Board of Science and Technology
  • Revised: 2010-04-15
  • Revised by: The Faculty Board of Science and Technology
  • Applies from: week 32, 2010
  • Entry requirements: 150 credits completed courses including alternative 1) 60 credits biology and 30 credits chemistry alternative 2) chemistry 60 credits including biochemistry 15 credits and biology 30 credits including molecular genetics 15 credits and cell biology 15 credits.
  • Responsible department: Biology Education Centre

Learning outcomes

The aim of the course is to provide the students with advanced knowledge and understanding of molecular processes in cells and organisms.

After the course, students will be able to


  • Explain the principles and the structural and mechanistic details of important processes in cells and organisms (cell growth, gene expressions, signal transduction, cell structure, cell differentiation and cell adhesion) and be able to discuss the complexity of the different interacting systems

  • Account for certain key experiments within the subject area

  • Analyse experimental data, and from the data, draw conclusions and formulate scientific hypotheses

  • Critically review chosen subjects within current research in the subject area and present analyses in the form of an oral presentation and a poster

  • Use certain important laboratory techniques within the subject area (mammalian cell culture, light optical microscopy and gel electrophoresis)

  • Analyse structural details in proteins and protein complexes by using molecular graphics program.

Content

The course consists of the following parts

Signal transduction: The principles of cell-to-cell communication via chemical signalling; signal molecules and receptors, components in intracellular signal pathways and their functions

The cytoskeleton: The architecture and dynamics of the three types of cytoskeleton systems and their motor proteins

Adhesion: Macromolecules in the extracellular matrix and the cellular adhesions proteins as well as their interactions; different types of adhesion complexes

The cell cycle: Regulation and mechanisms for cell replication in eukaryotes; the molecular mechanisms important for the development of cancer

Transcription: Roles of general and specific transcription factors in the initiation of transcription, protein-DNA interaction, and mRNA processing

Translation and protein targeting: Mechanisms of regulation of the translation initiation, mechanisms of peptide synthesis and control of the accuracy of protein synthesis, protein processing and quality control in the endoplasmic reticulum, vesicle-mediated protein transport

Computer exercises: The mechanistic details of different processes are studied in a number of computer exercises where the relevant macromolecules and their interactions are analysed

Laboratory sessions: Cultivation of mammalian cells, fluorescence microscopy, SDS-PAGE and silver staining.

Literature projects: The students work in groups with a chosen current research topic within the subject. The results are presented as a poster and a short oral presentation.

Instruction

The teaching is given in the form of lectures, seminars, computer exercises, laboratory sessions and literature projects. Participation in seminars, computer exercises, laboratory sessions and literature projects is compulsory. Integrated communication training with feedback and self evaluation occurs during the course.

Assessment

Modules: Signal transduction, transcription and translation 5 credits; The cell cycle, cytoskeleton and cell adhesion 5 credits; Laboratory sessions, seminars and literature project 5 credits
The module signal transduction, transcription and translation is examined with a written examination. The module the cell cycle, cytoskeleton and cell adhesion is examined with a written examination. The laboratory sessions are presented in the form of laboratory reports. The seminars require active participation and oral presentations. The literature project is presented as a poster and an oral presentation.

Reading list

The reading list is missing. For further information, please contact the responsible department.