Entry requirements

At least 180 credits (i.e. three years of full-time studies), in biology, (bio-)medicine, biotechnology, pharmaceutical bioscience, medical science or similar fields giving relevant knowledge in cell biology, genetics (bio) chemistry and molecular biology. Knowledge and practical experience of laboratory experiments in life sciences. Proficiency in English attested by TOEFL or IELTS (see entrance requirements www.uu.se).

Learning outcomes

The course aims to provide an in-depth knowledge of the field of regenerative medicine, from basic biology of stem cells to therapeutic applications.

After completing the course, the student should be able to

* describe different types of stem cells and their specific characteristics

* describe methods of applications to replace damaged or destroyed cells including tissue engineering

* account for regenerative medicine applications to human diseases

* account for and evaluate current theories, methods and techniques within the research field, their practical execution and application

* compile, critically analyse and evaluate research results and present these both orally and in writing.

Content

The course aims to provide an insight into the current knowledge, future potential use and development of regenerative medicine. Different kinds of stem cells will be discussed as well as tissue engineering and their applications in accelerating the healing process to restore injured or damaged tissues and organs. Basic stem cell biology as well as cellular programming and reprogramming will be covered. Clinical applications of stem cell therapies on diseases, such as e.g. Parkinson's, diabetes and cancer will be discussed as well as cell and gene therapy. Laboratory practicals include in vitro differentiation of neural as well as myeloid stem cells and determination of their specialisation using lineage markers assayed by FACS (Fluorescence Activated Cell Sorting) and immunofluorescence.

Biobanking of stem cells and the ethical considerations in regenerative medicine will be discussed, and current clinical applications will be illustrated. Development of novel approaches for enhancement, replacement or repair of cells as well as tissues and organs using bioengineered cellular methods and next generation biomaterials will be covered during the course. Criteria in good laboratory/manufacturing practice (GLP/GMP) for applications in regenerative medicine will be discussed as well as policies and commercial development.

Instruction

The teaching is given in the form of lectures, seminars, literature assignments, presentations related to current research fields as well as practical laboratory sessions. Participation in all the above-mentioned activities is compulsory.

Assessment

Modules: Theory and seminars 4.5 credits; Laboratory session 3 credits

The module laboratory sessions require completed laboratory practicals and related literature assignments. The theoretical module and seminars require active participation. A written examination is given at the end of the course. To pass the requirements of the curriculum, all assigned tasks must be completed.

Other directives

Selection to course: 1. Students submitted to the Master programme in Molecular Medicine. 2. Other students.

Knowledge and practical experience of laboratory experiments in life sciences is desirable.