Syllabus for Chemical Molecular Design

Kemisk molekylär design

A revised version of the syllabus is available.

Syllabus

  • 10 credits
  • Course code: 1KB453
  • Education cycle: Second cycle
  • Main field(s) of study and in-depth level: Chemistry A1N

    Explanation of codes

    The code indicates the education cycle and in-depth level of the course in relation to other courses within the same main field of study according to the requirements for general degrees:

    First cycle

    • G1N: has only upper-secondary level entry requirements
    • G1F: has less than 60 credits in first-cycle course/s as entry requirements
    • G1E: contains specially designed degree project for Higher Education Diploma
    • G2F: has at least 60 credits in first-cycle course/s as entry requirements
    • G2E: has at least 60 credits in first-cycle course/s as entry requirements, contains degree project for Bachelor of Arts/Bachelor of Science
    • GXX: in-depth level of the course cannot be classified

    Second cycle

    • A1N: has only first-cycle course/s as entry requirements
    • A1F: has second-cycle course/s as entry requirements
    • A1E: contains degree project for Master of Arts/Master of Science (60 credits)
    • A2E: contains degree project for Master of Arts/Master of Science (120 credits)
    • AXX: in-depth level of the course cannot be classified

  • Grading system: Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
  • Established: 2008-03-13
  • Established by: The Faculty Board of Science and Technology
  • Revised: 2014-04-23
  • Revised by: The Faculty Board of Science and Technology
  • Applies from: Autumn 2014
  • Entry requirements:

    120 credits in Science including 60 credits Chemistry, or equivalent.

  • Responsible department: Department of Chemistry - BMC

Learning outcomes

After successful completion of the course, the participant should have the ability to:

  • describe and discuss and perform design of compounds for molecular recognition of small and biomacromolecular targets
  • describe and discuss common properties and principles of organometallic and organocatalysts, enzymes and engineered enzymes
  • plan design and chemical modification of proteins
  • evaluate cost - benefit relationships in the design and synthesis of organic molecules
  • plan the preparation of simple artificial enzymes

Content

Design of small organic molecules for the recognition of bio-macromolecules, their surface or active centre. Recognition of domains and complexes.

Studies and comparison of different types of molecular recognition; small vs small (exemplified by organometallic and organocatalysts), small vs large (exemplified by natural and artificial enzymes), large vs large (exemplified by protein-protein interactions).

Design of molecules that inhibit the interaction between bio-macromolecules: inhibition of protein-protein interactions, inhibition of interactions of nucleic acids. Design and molecular recognition in drug discovery. Design of catalysts: organometallic catalysis and organocatalysis. Reengineering of enzymes, design of new enzymes.

The student shall in group projects identify suitable structures and plan their synthesis and evaluation.

Instruction

Lectures, seminars , literature searches, and theoretical projects. Training in oral and written reports. Participation in seminars and projects is mandatory.

Assessment

Written exam at the end of the course, 7 credits. The seminar and project corresponds to 3 credits. The final grade is a weighted combination of the individual grades.

Syllabus Revisions

Reading list

Reading list

Applies from: Autumn 2014

Some titles may be available electronically through the University library.

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