Syllabus for Chemical Molecular Design

Kemisk molekylär design

A revised version of the syllabus is available.

Syllabus

  • 10 credits
  • Course code: 1KB453
  • Education cycle: Second cycle
  • Main field(s) of study and in-depth level: Chemistry A1N

    Explanation of codes

    The code indicates the education cycle and in-depth level of the course in relation to other courses within the same main field of study according to the requirements for general degrees:

    First cycle

    • G1N: has only upper-secondary level entry requirements
    • G1F: has less than 60 credits in first-cycle course/s as entry requirements
    • G1E: contains specially designed degree project for Higher Education Diploma
    • G2F: has at least 60 credits in first-cycle course/s as entry requirements
    • G2E: has at least 60 credits in first-cycle course/s as entry requirements, contains degree project for Bachelor of Arts/Bachelor of Science
    • GXX: in-depth level of the course cannot be classified

    Second cycle

    • A1N: has only first-cycle course/s as entry requirements
    • A1F: has second-cycle course/s as entry requirements
    • A1E: contains degree project for Master of Arts/Master of Science (60 credits)
    • A2E: contains degree project for Master of Arts/Master of Science (120 credits)
    • AXX: in-depth level of the course cannot be classified

  • Grading system: Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
  • Established: 2008-03-13
  • Established by: The Faculty Board of Science and Technology
  • Revised: 2015-04-16
  • Revised by: The Faculty Board of Science and Technology
  • Applies from: Autumn 2015
  • Entry requirements:

    120 credits with 60 credits in chemistry.

  • Responsible department: Department of Chemistry - BMC

Learning outcomes

After successful completion of the course, the participant should have the ability to:

  • describe, discuss and perform design of compounds for molecular recognition of small organic molecules as well as large biomolecules, in particular proteins
  • describe and discuss the properties and principles that are common to the binding of molecules to each other and to catalysis.
  • plan design and chemical modification of proteins
  • evaluate cost - benefit relationships in the design and synthesis of organic molecules that bind to different types of molecular targets
  • describe how the basic principles of chemical molecular design can be applied to the design of functional biomaterials

Content

Studies and comparison of molecular recognition: small vs small (supramolecular chemistry), small vs large (drug-protein and substrate-enzyme interactions), large vs large (protein-protein interactions).

Application of these principles to the design of molecules that inhibit the interaction between biomacromolecules and between ligands and biomacromolecules, for the development of chemical tools and of drugs.

Modification and design of enzymes and catalytically active polypeptides.

Design of functional surfaces and polymeric biomaterials.

Instruction

Lectures, seminars, literature searches, group work and theoretical projects. Training in oral and written communication . Participation in seminars and projects is mandatory.

Assessment

Written exam at the end of the course, 7 credits. The seminar and project correspond to 3 credits. The final grade is a weighted combination of the individual grades.

Syllabus Revisions

Reading list

Reading list

Applies from: Autumn 2015

Some titles may be available electronically through the University library.

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