Syllabus for Structural Bioinformatics
A revised version of the syllabus is available.
- 5 credits
- Course code: 1MB204
- Education cycle: First cycle
Main field(s) of study and in-depth level:
Explanation of codes
The code indicates the education cycle and in-depth level of the course in relation to other courses within the same main field of study according to the requirements for general degrees:
- G1N: has only upper-secondary level entry requirements
- G1F: has less than 60 credits in first-cycle course/s as entry requirements
- G1E: contains specially designed degree project for Higher Education Diploma
- G2F: has at least 60 credits in first-cycle course/s as entry requirements
- G2E: has at least 60 credits in first-cycle course/s as entry requirements, contains degree project for Bachelor of Arts/Bachelor of Science
- GXX: in-depth level of the course cannot be classified
- A1N: has only first-cycle course/s as entry requirements
- A1F: has second-cycle course/s as entry requirements
- A1E: contains degree project for Master of Arts/Master of Science (60 credits)
- A2E: contains degree project for Master of Arts/Master of Science (120 credits)
- AXX: in-depth level of the course cannot be classified
- Grading system: Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
- Established: 2016-03-08
- Established by: The Faculty Board of Science and Technology
- Revised: 2017-04-25
- Revised by: The Faculty Board of Science and Technology
- Applies from: Autumn 2017
60 credits within the Master Programme in Molecular Biotechnology Engineering, includning Cell Biology and Basic Chemistry.
- Responsible department: Biology Education Centre
After completing the course, the student should be able to
- explain the relationship between protein sequence and protein structure
- describe how structure translates into function within different biological fields such as catalysis, transport and regulation
- estimate the validity of information in macromolecular structure databases, and use computer programs to visualise and analyse macromolecular structures from a functional perspective
- use bioinformatics tools for sequence alignment, sequence motif identification and prediction of secondary and tertiary structures
- account for the purpose, theoretical background, ethical aspects and limitations of the above mentioned bioinformatics methods and use this knowledge to interpret relevant results.
Relation between sequence, structure and function. Structural basis for macromolecular dynamics, binding specificity and catalysis.
Overview of biological databases, servers and information centres. Sequence comparisons. Basic macromolecular structure: three-dimensional structure, PDB co-ordinates, classification of proteins in structure families, programs for analysis and comparison of structures. Introduction to the theory of classification and comparison of sequences and extraction of common distinctive features (e.g., motifs). Sequence analysis for prediction of secondary and tertiary structures, and homology modelling of three-dimensional structures based on sequence data. Research and publication ethics.
Lectures, seminars and computer exercises. Attendance at seminars and full participation in computer labs is mandatory to pass the course.
Written examination ( 3 credits) , laboratory, exercises and seminars ( 2 credits) .
Applies from: Spring 2019
Some titles may be available electronically through the University library.
Textbook of structural biology
Second edition.: [Hackensack] New Jersey: World Scientific, 2017.
Reading list revisions
- Latest reading list (applies from Spring 2019)
- Previous reading list (applies from Autumn 2017)