Syllabus for Pharmacokinetics
- 7.5 credits
- Course code: 3FF216
- Education cycle: First cycle
Main field(s) of study and in-depth level:
Pharmaceutical Sciences G2F,
Explanation of codes
The code indicates the education cycle and in-depth level of the course in relation to other courses within the same main field of study according to the requirements for general degrees:
- G1N: has only upper-secondary level entry requirements
- G1F: has less than 60 credits in first-cycle course/s as entry requirements
- G1E: contains specially designed degree project for Higher Education Diploma
- G2F: has at least 60 credits in first-cycle course/s as entry requirements
- G2E: has at least 60 credits in first-cycle course/s as entry requirements, contains degree project for Bachelor of Arts/Bachelor of Science
- GXX: in-depth level of the course cannot be classified
- A1N: has only first-cycle course/s as entry requirements
- A1F: has second-cycle course/s as entry requirements
- A1E: contains degree project for Master of Arts/Master of Science (60 credits)
- A2E: contains degree project for Master of Arts/Master of Science (120 credits)
- AXX: in-depth level of the course cannot be classified
- Grading system: Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
- Established: 2016-05-26
- Established by:
- Revised: 2022-08-25
- Revised by: The Educational Board of Pharmacy
- Applies from: Autumn 2023
120 credits in biomedicine, pharmaceutical science, natural sciences and/or engineering. Prior studies must include 15 credits general and organic chemistry, 6 credits physiology and 7.5 credits pharmacology.
- Responsible department: Department of Pharmacy
- Other participating department(s): Faculty of Science and Technology
Decisions and guidelines
The course is part of the curriculum at the Master of Science Programme in Chemical Engineering, specialisation Pharmacy and in the Master Programme in Drug Discovery and Development.
On completion of the course, the student should be able to:
- describe how basic pharmacokinetic processes, as absorption, distribution and elimination, are defined, expressed, calculated, affected, and how these processes in combination determine drug disposition in the organism over time
- explain how pharmacokinetics together with pharmacodynamics determines the effect intensity and effect duration of a drug
- establish dosing regimens for drugs based on their pharmacokinetic and pharmacodynamic characteristics, use given dosing regimens for calculation of concentrations, and describe how doses should be adjusted due to variability in pharmacokinetic parameters
- apply pharmacokinetic principles, including drug interactions to explain individual variation in drug disposition, and account for the consequences of this
- generate and evaluate pharmacokinetic and pharmacodynamic parameters in an individual PKPD assignment and use these for population-level predictions
- orally present a drug interaction, explain the mechanisms and evaluate the consequences of the interaction
This is a basic course in pharmacokinetics, i.e. about the uptake and disposition of drugs in the body, and in pharmacodynamics, i.e. the description of drug effects with special focus on the time course of the effect(s).
The course deals with absorption, plasma protein binding, tissue distribution and elimination of drugs by liver and kidneys and how these processes determine the overall disposition of the drug in the organism. In addition, the relationships between dose - concentration - effect are described. The course also deals with calculation and evaluation of parameters that describe pharmacokinetic and pharmacodynamic processes, both regarding single dose and repeated dose administration. Finally, it describes the theoretical basis for clinical drug dosing, reasons for and rational handling of inter-individual variation in drug disposition as well as drug-drug interactions.
During the course, the student works with a drug interaction from an article. The interaction should be presented with regard to how the drugs involved affect e.g. pharmacokinetic parameters and what the consequences may be in different patient groups.
In a web-based, interactive, individual assignment, data is generated through a simulated clinical trial with the aim of training and understanding of pharmacokinetic and pharmacodynamic parameters. At a final workshop, these parameters are used to predict drug concentration and/or variability in patient populations.
Teaching is carried out through lectures, seminars, workshops computer laboratory sessions.
Workshop PKPD and the seminar for interaction are compulsory.
The course is given in English.
Written examination is arranged at the end of the course. In order to pass the course, the student must have completed all compulsory exercises (Workshop PKPD 2 credits and seminar for interactions 0,5 credits) as well as the written exam (5 credits).
If there are special reasons for doing so, an examiner may make an exception from the method of assessment indicated and allow a student to be assessed by another method. An example of special reasons might be a certificate regarding special pedagogical support from the disability coordinator of the university.
Corresponds to and replaces 1TK055 or 3FF660
- Latest syllabus (applies from Autumn 2023)
- Previous syllabus (applies from Autumn 2020, version 2)
- Previous syllabus (applies from Autumn 2020, version 1)
- Previous syllabus (applies from Autumn 2019)
- Previous syllabus (applies from Autumn 2017, version 2)
- Previous syllabus (applies from Autumn 2017, version 1)
The reading list is missing. For further information, please contact the responsible department.