Main field(s) of study and in-depth level:
Pharmaceutical Sciences G2F,
Explanation of codes
The code indicates the education cycle and in-depth level of the course in relation to other courses within the same main field of study according to the requirements for general degrees:
G1N: has only upper-secondary level entry requirements
G1F: has less than 60 credits in first-cycle course/s as entry requirements
G1E: contains specially designed degree project for Higher Education Diploma
G2F: has at least 60 credits in first-cycle course/s as entry requirements
G2E: has at least 60 credits in first-cycle course/s as entry requirements, contains degree project for Bachelor of Arts/Bachelor of Science
GXX: in-depth level of the course cannot be classified
A1N: has only first-cycle course/s as entry requirements
A1F: has second-cycle course/s as entry requirements
A1E: contains degree project for Master of Arts/Master of Science (60 credits)
A2E: contains degree project for Master of Arts/Master of Science (120 credits)
AXX: in-depth level of the course cannot be classified
Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
The Educational Board of Pharmacy
120 credits in biomedicine, pharmaceutical science, natural sciences and/or engineering. Prior studies must include 15 credits general and organic chemistry, 6 credits physiology and 7.5 credits pharmacology.
The course is part of the curriculum at the Master of Science Programme in Chemical Engineering, specialisation Pharmacy and in the Master Programme in Drug Discovery and Development.
On completion of the course, the student should be able to:
describe how basic pharmacokinetic processes, as absorption, distribution and elimination, are defined, expressed, calculated, affected, and how these processes in combination determine drug disposition in the organism over time
explain how pharmacokinetics together with pharmacodynamics determines the effect intensity and effect duration of a drug
establish dosing regimens for drugs based on their pharmacokinetic and pharmacodynamic characteristics, use given dosing regimens for calculation of concentrations, and describe how doses should be adjusted due to variability in pharmacokinetic parameters
apply pharmacokinetic principles, including drug interactions to explain individual variation in drug disposition, and account for the consequences of this
generate and evaluate pharmacokinetic and pharmacodynamic parameters in an individual PKPD assignment and use these for population-level predictions
orally present a drug interaction, explain the mechanisms and evaluate the consequences of the interaction
This is a basic course in pharmacokinetics, i.e. about the uptake and disposition of drugs in the body, and in pharmacodynamics, i.e. the description of drug effects with special focus on the time course of the effect(s).
The course deals with absorption, plasma protein binding, tissue distribution and elimination of drugs by liver and kidneys and how these processes determine the overall disposition of the drug in the organism. In addition, the relationships between dose - concentration - effect are described. The course also deals with calculation and evaluation of parameters that describe pharmacokinetic and pharmacodynamic processes, both regarding single dose and repeated dose administration. Finally, it describes the theoretical basis for clinical drug dosing, reasons for and rational handling of inter-individual variation in drug disposition as well as drug-drug interactions.
During the course, the student works with a drug interaction from an article. The interaction should be presented with regard to how the drugs involved affect e.g. pharmacokinetic parameters and what the consequences may be in different patient groups.
In a web-based, interactive, individual assignment, data is generated through a simulated clinical trial with the aim of training and understanding of pharmacokinetic and pharmacodynamic parameters. At a final workshop, these parameters are used to predict drug concentration and/or variability in patient populations.
Teaching is carried out through lectures, seminars, workshops computer laboratory sessions.
Workshop PKPD and the seminar for interaction are compulsory.
The course is given in English.
Written examination is arranged at the end of the course. In order to pass the course, the student must have completed all compulsory exercises (Workshop PKPD 2 credits and seminar for interactions 0,5 credits) as well as the written exam (5 credits).
If there are special reasons for doing so, an examiner may make an exception from the method of assessment indicated and allow a student to be assessed by another method. An example of special reasons might be a certificate regarding special pedagogical support from the disability coordinator of the university.