Syllabus for Proteins and Drugs

Proteiner och läkemedel

Syllabus

  • 5 credits
  • Course code: 1KB423
  • Education cycle: First cycle
  • Main field(s) of study and in-depth level: Chemistry G2F, Biology G2F
  • Grading system: Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
  • Established: 2016-03-10
  • Established by:
  • Revised: 2018-08-30
  • Revised by: The Faculty Board of Science and Technology
  • Applies from: Spring 2019
  • Entry requirements: One of the following is required: (1) 60 credits of which at least 40 credits in chemistry including 15 credits biochemistry and participation in Structure and Function of Proteins, or (2) 60 credits of which at least 40 credits in biology, together with 15 credits in biochemistry and participation in Structure and Function of Proteins.
  • Responsible department: Department of Chemistry - BMC

Learning outcomes

On completion of the course, the student should be able to:

  • describe how the properties of proteins relate to various disease processes
  • describe the mechanism of drugs directed against proteins
  • principally design a molecule that interferes with the normal function of a protein
  • experimentally identify and characterise molecules that interfere with the normal functions of proteins
  • produce and present a scientific poster

Content

Examples and concepts: Projects defined by protein class, e.g. proteases. Projects by defined disease areas, e.g. cancer, antiviral drugs.
Pharmaceutical substances: Nature as a source for drugs. Rational drug design. Fragment based drug discovery.
Drug targets: Receptors, ion channels, enzymes, nucleic acids.
Biochemical methods for drug development: Target identification and characterisation. Lead identification and characterisation.
Lead optimisation: selectivity, resistance, ADME, pro-drugs.
From the pharmaceutical industry to the clinic.
Individual project: The mechanism of action for a given drug at the biochemical level has to be presented in form of a scientific poster.

Instruction

The course is given in form of lectures and to a large extent in form of theoretical exercises and projects.
Exercises and projects are compulsory and are carried out individually.

Assessment

Experimental and theoretical exercises and projects (2.5 credits) are examined during the course. An overall written examination (2.5 credits) is given at the end of the course. The final grade for the course is given as a weighted average grade for all compulsory parts.

If there are special reasons for doing so, an examiner may make an exception from the method of assessment indicated and allow a student to be assessed by another method. An example of special reasons might be a certificate regarding special pedagogical support from the disability coordinator of the university.

Other directives

Cannot be included in a degree together with the course Proteins and drugs 5 credits (1KB404).

Reading list

Reading list

Applies from: Spring 2019

Some titles may be available electronically through the University library.

Scientific articles and Internet resources for drug discovery.

  • Nelson, David L.; Cox, Michael M. Lehninger principles of biochemistry

    Seventh, international edition.: New York, NY: W.H. Freeman, [2017]

    Find in the library

Last modified: 2022-04-26