After successful completion of the course, the partcipant should have the ability to:
consider the complexity that is needed in a molecule to solve a particular scientific problem.
evaluate cost - benefit relationship in the design and synthesis of organic molecules
describe and discuss design scaffolds for molecular recognition of small and biomacromolecular targets.
plan design and chemical modification of proteins
describe and discuss common properties and principles of organometallic and organocatalysts, artificial enzymes and engineered enzymes.
prepare simple artificial enzymes.
Studies and comparison of different types of molecular recognition; small vs small (exemplified by metalorganic- and organocatalysts), small vs large (exemplified by natural and artificial enzymes), large vs large (exemplified by protein protein interactions).
During the laborative part of the course the student will formulate, synthesise and evaluate a structure suitable for molecular recognition as an artificial enzyme.
Lectures, exercises, laboratory work and discussions. Participation in exercises and projects is mandatory. Training in oral and written reports
Written exam at the end of the course. The laboratory exercises as well as the theoretical work must be passed in order for the student to pass the whole course. Division of points: Written exam 7 credits, mandatory exercises, laboratory work and their reports 3 credits.