Syllabus for Molecular Cell Biology

Content

In the course, the following part is included

Signal transduction: The principles for chemical communication between cells; signal molecules and receptors, components in intracellular signal paths and their function

The cytoskeleton: The architecture and the dynamics at the three cytoskeleton systems and their motor proteins

Adhesion: Proteins in the extracellular matrix and the cellular adhesions proteins and their interactions; various types of adhesions complexes; the nerve synapse as examples of a specialised cell contact

The cell cycle: Regulation and mechanisms for cell replication in prokaryotes and eukaryotes; the importance of molecular mechanisms for origin of cancer growth

Transcription: The roles of general and specific transcription factors for the initiation of the transcription, protein-DNA interaction, the mRNA processing

Translation and protein targeting: Mechanisms for regulation of initiation of the translation, mechanisms for the peptide synthesis and the control of the precision in the synthesis, the protein processing and quality control in endoplasmic reticulum, the vesicle carried protein transport

Computer exercises: The mechanistic details of different processes are studied in a number of computer exercises, where the detailed macro molecules and their interactions are analysed

Laboratory work: Cultivation of mammal cells, fluorescence microscopy, immunoprecipitering of protein, gels of the SDS-PAGE and silver staining.

Project: The students work in groups with a chosen current research field within the subject. The results are presented as a posts and a short oral presentation.