Syllabus for Chemical Molecular Design

Kemisk molekylär design

A revised version of the syllabus is available.


  • 10 credits
  • Course code: 1KB453
  • Education cycle: Second cycle
  • Main field(s) of study and in-depth level: Chemistry A1N
  • Grading system: Fail (U), Pass (3), Pass with credit (4), Pass with distinction (5)
  • Established: 2008-03-13
  • Established by: The Faculty Board of Science and Technology
  • Revised: 2014-04-23
  • Revised by: The Faculty Board of Science and Technology
  • Applies from: Autumn 2014
  • Entry requirements: 120 credits in Science including 60 credits Chemistry, or equivalent.
  • Responsible department: Department of Chemistry - BMC

Learning outcomes

After successful completion of the course, the participant should have the ability to:

  • describe and discuss and perform design of compounds for molecular recognition of small and biomacromolecular targets
  • describe and discuss common properties and principles of organometallic and organocatalysts, enzymes and engineered enzymes
  • plan design and chemical modification of proteins
  • evaluate cost - benefit relationships in the design and synthesis of organic molecules
  • plan the preparation of simple artificial enzymes


Design of small organic molecules for the recognition of bio-macromolecules, their surface or active centre. Recognition of domains and complexes.

Studies and comparison of different types of molecular recognition; small vs small (exemplified by organometallic and organocatalysts), small vs large (exemplified by natural and artificial enzymes), large vs large (exemplified by protein-protein interactions).

Design of molecules that inhibit the interaction between bio-macromolecules: inhibition of protein-protein interactions, inhibition of interactions of nucleic acids. Design and molecular recognition in drug discovery. Design of catalysts: organometallic catalysis and organocatalysis. Reengineering of enzymes, design of new enzymes.

The student shall in group projects identify suitable structures and plan their synthesis and evaluation.


Lectures, seminars , literature searches, and theoretical projects. Training in oral and written reports. Participation in seminars and projects is mandatory.


Written exam at the end of the course, 7 credits. The seminar and project corresponds to 3 credits. The final grade is a weighted combination of the individual grades.

Reading list

Reading list

Applies from: Autumn 2014

Some titles may be available electronically through the University library.

Last modified: 2022-04-26