Andrew Jackson, ESS: "Protein in Deep Eutectic Solvents"
Time: 27 November, at 15:15 hrs
Place: Room 2004, Ångström Laboratory
Andrew Jackson, who is leader of the Large Scale Structures division at the European Spallation Source, will visit Uppsala on 27 and the morning of 28 November.
At 15:15 hrs on 27th November he will present a seminar on "Proteins in Deep Eutectic Solvents" in Ångströmlab, room 2004. See abstract below.
Fika will be served before the seminar.
NOTE: Andrew will be happy to discuss opportunities generally for experiments at ESS with the Large Scale Structures instruments. Please contact Adrian Rennie (adrian.rennie@kemi.uu.se) if you want to book a meeting with Andrew during his visit.
For more information, please contact Adrian Rennie.
Abstract
"Proteins in Deep Eutectic Solvents"
Andrew Jackson
European Spallation Source & Lund University, Lund, Sweden
The preservation of biomolecules presents a major challenge in chemistry, and deep eutectic solvents (DESs) have emerged as suitable environments for this purpose. DES are solvents obtained through the complexation of organic compounds, where the interaction between the precursors promotes a depression in the melting point that allows the mixture to remain liquid at room temperature. Moreover, through different combinations of precursors the physicochemical properties of the solvent can be tuned for particular applications. One important characteristic of DES is that they can tolerate the presence of relatively high fractions of water before losing the solvent hydrogen bond network. Thus, the degree of hydration is another tunable parameter available for optimization of the system properties.
This seminar will discuss deep eutectic solvents in general, the tunability of the solvents, the behaviour of proteins in these solvents, and the effect of hydration on the folding and stability of proteins.
References
- A. Sanchez-Fernandez, K. J. Edler, T. Arnold, D. A. Venero and A. J. Jackson, Phys. Chem. Chem. Phys., 2017, 19, 8667–8670.
- A. Sanchez-Fernandez and A. J. Jackson, in Advances in Botanical Research, Elsevier, 2021, vol. 97, pp. 69–94.
- A. Sanchez-Fernandez, M. Basic, J. Xiang, S. Prevost, A. J. Jackson and C. Dicko, J. Am. Chem. Soc., 2022, 144, 23657–23667.