Pharmaceutical Profiling in Drug Discovery and Development
- Date: 23 January 2025, 08:00 – 24 January 2025, 13:00
- Location: Grand Auditorium
- Type: Conference
- Organiser: Uppsala University, Nordic Pharma Train, SciLifeLab, UDOPP, SweDeliver & Nordic POP
- Contact person: Shakhawath Hossain
- Research topic: Drug development
Welcome to the 13th Uppsala University Symposium on Pharmaceutical Profiling in Drug Discovery and Development. This symposium will focus on drug delivery and disposition, therapies, and strategies including Artificial Intelligence and Machine Learning used in drug discovery and development projects (DDD).
The symposium will also honor Professor Per Artursson, SciLifeLab DDD scientific platform director, and his distinguished research career.
Register no later than 20 December at https://doit.medfarm.uu.se/bin/kurt3/kurt/8877640
Program 23 January
08:00–08:45 Registration
08:45–08:55 Welcome Talk, Christel Bergström, Uppsala University, Sweden
Session 1: Chair: Pär Matsson, University of Gothenburg, Sweden
08:55–09:35 Kathy Giacomini, University of California San Francisco, USA
09:35–09:55 Madlen Hubert, Uppsala University, Sweden
3D human intestinal organoids: a predictive screening tool for oral drug delivery
09:55–10.25 Coffee break and poster mounting:
Session 2: Chair: Andre Mateus, Umeå University, Sweden
10:25–11:05 Kim Brouwer, UNC Eshelman School of Pharmacy, USA
Opportunities and Challenges in Predicting Hepatic Transporter-mediated Changes in Drug Disposition, Efficacy and Safety in Patients with MASLD
11:05–11:45 Volker Lauschke, Karolinska Institutet (KI), Sweden
Organotypic and microphysiological model systems for translational pharmacology
11:45–12:00 Evgeniya Mickols, Uppsala University
Evaluation and elevation of 3D primary human hepatocyte spheroids
12:00–13.00 Lunch break
Session 3: Chair: Alexandra Teleki, Uppsala University, Sweden
13:00–13:40 David Brayden, University College Dublin, Ireland
Formulation approaches to improve oral delivery of peptides-an update
13:40–14:20 Mike Hann, former GlaxoSmithKline, UK
Molecular Accessibility - Lessons in Transcellular Membrane Transport re-learned
14:20–14:35 Alina Meyer, Uppsala University
Target identification for drug repurposing in polycystic kidney disease
14:35–15.45 Coffee break and poster session
Session 4: Chair: Pawel Baranczewski, Uppsala University, Sweden
15:45–16:25 Thomas Helleday, Karolinska Institutet (KI), Sweden
16:25–16:45 Kristian Sandberg, ScilLifeLab DDD, Uppsala University, Sweden
Rewiring of SciLifeLab DDD to target the undruggable
16:45–17:05 Annika Jenmalm Jensen, ScilLifeLab, KI, Sweden
From Inception to Impact: The Story of CBCS
17:05–17:15 Pawel Baranczewski, ScilLifeLab DDD, Uppsala University, Sweden
The impact of UDOPP on Swedish academic drug discovery
Program 24 January
Session 5: Chair: Christel Bergström, Uppsala University, Sweden
09:00–09:40 Wojciech Chrzanowski, University of Sydney, Australia
09:40–09:55 Prosper Emeh, Uppsala University
Effect of peptide lipidation, chemical structure and formulation on luminal stability and intestinal absorption
09:55–11.00 Coffee break and poster session
Session 6: Chair: Per Larsson, Uppsala University, Sweden
11:00–11:30 Sibylle Neuhoff, Certara UK Ltd.
Hepatic transporter-mediated DDIs assessed via PBPK modelling
11:30–11:50 Pär Matsson, University of Gothenburg, Sweden
Cellular exposure of new-modality therapeutics
11:50–12:10 André Mateus, Umeå University, Sweden
Gut bugs on sugars and drugs
12:10–12:30 Christel Bergström, Uppsala University, Sweden
Contemporary models and pharmaceutical production – from a virtual intestine to 3D printed medicines
12:30–13:00 Closing remark and take away lunch