Alejandro Diaz

Identification of bioactive compounds with popular single-atom modifications: Comprehensive analysis and implications for compound design

Feng, Bo; Yu, Hui; Dong, Xu; Díaz-Holguín, Alejandro et al.

Part of European Journal of Medicinal Chemistry, 2025

• DOI for Identification of bioactive compounds with popular single-atom modifications: Comprehensive analysis and implications for compound design

Combining Data-Driven and Structure-Based Approaches in Designing Dual PARP1-BRD4 Inhibitors for Breast Cancer Treatment

Feng, Bo; Yu, Hui; Dong, Xu; Díaz-Holguín, Alejandro et al.

Part of Journal of Chemical Information and Modeling, p. 7725-7742, 2024

• DOI for Combining Data-Driven and Structure-Based Approaches in Designing Dual PARP1-BRD4 Inhibitors for Breast Cancer Treatment
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AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1

Díaz-Holguin, Alejandro; Saarinen, Marcus; Vo, Duc Duy; Sturchio, Andrea et al.

Part of Science Advances, 2024

• DOI for AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1
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Exploring the Effect of Halogenation in a Series of Potent and Selective A_2B Adenosine Receptor Antagonists

Prieto-Díaz, Rubén; González-Gómez, Manuel; Fojo-Carballo, Hugo; Azuaje, Jhonny et al.

Part of Journal of Medicinal Chemistry, p. 890-912, 2023

• DOI for Exploring the Effect of Halogenation in a Series of Potent and Selective A_2B Adenosine Receptor Antagonists
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When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists

Diaz-Holguin, Alejandro; Rashidian, Azam; Pijnenburg, Dirk; Monteiro Ferreira, Glaucio et al.

Part of ChemMedChem, 2023

• DOI for When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists
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Identification of bioactive compounds with popular single-atom modifications: Comprehensive analysis and implications for compound design

Feng, Bo; Yu, Hui; Dong, Xu; Díaz-Holguín, Alejandro et al.

Part of European Journal of Medicinal Chemistry, 2025

• DOI for Identification of bioactive compounds with popular single-atom modifications: Comprehensive analysis and implications for compound design

Combining Data-Driven and Structure-Based Approaches in Designing Dual PARP1-BRD4 Inhibitors for Breast Cancer Treatment

Feng, Bo; Yu, Hui; Dong, Xu; Díaz-Holguín, Alejandro et al.

Part of Journal of Chemical Information and Modeling, p. 7725-7742, 2024

• DOI for Combining Data-Driven and Structure-Based Approaches in Designing Dual PARP1-BRD4 Inhibitors for Breast Cancer Treatment
• Download full text (pdf) of Combining Data-Driven and Structure-Based Approaches in Designing Dual PARP1-BRD4 Inhibitors for Breast Cancer Treatment

AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1

Díaz-Holguin, Alejandro; Saarinen, Marcus; Vo, Duc Duy; Sturchio, Andrea et al.

Part of Science Advances, 2024

• DOI for AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1
• Download full text (pdf) of AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1

Exploring the Effect of Halogenation in a Series of Potent and Selective A_2B Adenosine Receptor Antagonists

Prieto-Díaz, Rubén; González-Gómez, Manuel; Fojo-Carballo, Hugo; Azuaje, Jhonny et al.

Part of Journal of Medicinal Chemistry, p. 890-912, 2023

• DOI for Exploring the Effect of Halogenation in a Series of Potent and Selective A_2B Adenosine Receptor Antagonists
• Download full text (pdf) of Exploring the Effect of Halogenation in a Series of Potent and Selective A_2B Adenosine Receptor Antagonists

When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists

Diaz-Holguin, Alejandro; Rashidian, Azam; Pijnenburg, Dirk; Monteiro Ferreira, Glaucio et al.

Part of ChemMedChem, 2023

• DOI for When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists
• Download full text (pdf) of When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists