Marco Marcia

Short presentation

Keywords

• long non-coding rnas
• rna cryoem
• rna crystallography
• rna-directed drug design
• splicing

Biography

Media

MSCA doctoral training network - TargetRNA

TargetRNA comprises 16 doctoral candidates, who will work together across different disciplines to jointly advance the field of RNA-ligand design. We direct DC16.

https://www.uib.no/en/targetrna

Research project DansaRNA

DansaRNA is a project funded by the Swedish National Research Council (VR), through which we will visualize novel RNA structures and their conformational dynamics to understand their function

https://www.vr.se/english.html

Research project SplicINH

SplicINH is a project funded by AIRC, through which we will study small RNA-targeting splicing modulators. This project is run at IIT Genova, Italy

https://www.airc.it/ricercatori/i-nostri-ricercatori/marco-marcia

Battistini Lecture at the Institute of Advanced Studies, Bologna University

In this lecture, I discuss the biological functions and therapeutic potential of RNA in a divulgative manner

https://www.youtube.com/watch?v=79NOLt5w4g8&t=1s

LUMSA University Innovation Talks

In this lecture, I discuss how robotics and AI contribute to understanding biological mechanisms

https://www.youtube.com/watch?v=xdW_wxyxprc&list=PLhegWhuzdeKOqyN8csSJL2sMoM7uAv1L7&index=9

Publications

Selection of publications

• Targeting the conserved active site of splicing machines with specific and selective small molecule modulators. (2024)
• Visualizing group II intron dynamics between the first and second steps of splicing. (2020)
• Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques. (2020)
• Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway. (2019)
• Visualizing group II intron catalysis through the stages of splicing. (2012)

Recent publications

• On the Power and Challenges of Atomistic Molecular Dynamics to Investigate RNA Molecules. (2024)
• Targeting the conserved active site of splicing machines with specific and selective small molecule modulators. (2024)
• The new world of RNA diagnostics and therapeutics. (2023)
• G·U base pairing motifs in long non-coding RNAs. (2023)
• The multiple molecular dimensions of long noncoding RNAs that regulate gene expression and tumorigenesis. (2022)

All publications

Articles

• On the Power and Challenges of Atomistic Molecular Dynamics to Investigate RNA Molecules. (2024)
• Targeting the conserved active site of splicing machines with specific and selective small molecule modulators. (2024)
• The new world of RNA diagnostics and therapeutics. (2023)
• G·U base pairing motifs in long non-coding RNAs. (2023)
• The multiple molecular dimensions of long noncoding RNAs that regulate gene expression and tumorigenesis. (2022)
• ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts. (2022)
• Noncoding RNAs (2021)
• Computer-aided design of RNA-targeted small molecules: A growing need in drug discovery (2021)
• Finding the Ion in the RNA-Stack (2021)
• Screening strategies for identifying RNA- and ribonucleoprotein-targeted compounds. (2021)
• The molecular structure of long non-coding RNAs (2020)
• Visualizing group II intron dynamics between the first and second steps of splicing. (2020)
• Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques. (2020)
• Topology and enzymatic properties of a canonical Polycomb repressive complex 1 isoform. (2019)
• A group II intron-encoded protein interacts with the cellular replicative machinery through the β-sliding clamp. (2019)
• A Transient and Flexible Cation-π Interaction Promotes Hydrolysis of Nucleic Acids in DNA and RNA Nucleases. (2019)
• Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway. (2019)
• Second-Shell Basic Residues Expand the Two-Metal-Ion Architecture of DNA and RNA Processing Enzymes. (2018)
• Identification of high-confidence RNA regulatory elements by combinatorial classification of RNA-protein binding sites. (2017)
• Using Molecular Replacement Phasing to Study the Structure and Function of RNA. (2016)
• Native Purification and Analysis of Long RNAs. (2015)
• HOTAIR forms an intricate and modular secondary structure. (2015)
• Crystal structure of group II intron domain 1 reveals a template for RNA assembly. (2015)
• Principles of ion recognition in RNA (2014)
• Production of fully assembled and active Aquifex aeolicus F1FO ATP synthase in Escherichia coli. (2014)
• Solving nucleic acid structures by molecular replacement (2013)
• Now on display (2013)
• Role of the N-terminal signal peptide in the membrane insertion of Aquifex aeolicus F1F0 ATP synthase c-subunit. (2013)
• Visualizing group II intron catalysis through the stages of splicing. (2012)
• Ion binding and internal hydration in the multidrug resistance secondary active transporter NorM investigated by molecular dynamics simulations. (2012)
• PICKScreens, A New Database for the Comparison of Crystallization Screens for Biological Macromolecules (2010)
• A new structure-based classification of sulfide (2010)
• Characterizing a monotopic membrane enzyme. Biochemical, enzymatic and crystallization studies on Aquifex aeolicus sulfide (2010)
• The structure of Aquifex aeolicus sulfide (2009)