Michael Vanlandewijck

A molecular atlas of cell types and zonation in the brain vasculature

Vanlandewijck, Michael; He, Liqun; Mäe, Maarja Andaloussi; Andrae, Johanna et al.

Part of Nature, p. 475-480, 2018

• DOI for A molecular atlas of cell types and zonation in the brain vasculature

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

He, Liqun; Vanlandewijck, Michael; Mäe, Maarja Andaloussi; Andrae, Johanna et al.

Part of Scientific Data, 2018

• DOI for Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types
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Analysis of the brain mural cell transcriptome

He, Liqun; Vanlandewijck, Michael; Raschperger, Elisabeth; Mae, Maarja Andaloussi et al.

Part of Scientific Reports, 2016

• DOI for Analysis of the brain mural cell transcriptome
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Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification

Vanlandewijck, Michael; Lebouvier, Thibaud; Mae, Maarja Andaloussi; Nahar, Khayrun et al.

Part of PLOS ONE, 2015

• DOI for Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification
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Regulation of EMT by TGFβ in cancer

Heldin, Carl-Henrik; Vanlandewijck, Michael; Moustakas, Aristidis

Part of FEBS Letters, p. 1959-1970, 2012

• DOI for Regulation of EMT by TGFβ in cancer

SIK phosphorylates and degrades Par3 to mediate tight junction disassembly during epithelial-mesenchymal transition

Vanlandewijck, Michael; Lomnytska, Marta; Busch, Christer; Heldin, Carl-Henrik et al.

2011

Diversification of TGF-β Signaling in Homeostasis and Disease

Vanlandewijck, Michael

2011

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Notch signaling is necessary for epithelial growth arrest by TGF-beta

Niimi, Hideki; Pardali, Katerina; Vanlandewijck, Michael; Heldin, Carl-Henrik et al.

Part of Journal of Cell Biology, p. 695-707, 2007

• DOI for Notch signaling is necessary for epithelial growth arrest by TGF-beta

A reference protein atlas of the adult mouse brain vasculature

He, Liqun; Johansson, Henrik J.; Vazquez-Liebanas, Elisa; Liu, Jianping et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2026

• DOI for A reference protein atlas of the adult mouse brain vasculature
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Heterogenous microglial reactivity contrasts with stable vascular transcriptional programs in mouse models of Alzheimer's, CADASIL, and Traumatic Brain Injury

Bjørnholm, K. D.; Li, H.; Del Gaudio, F.; Mocci, G. et al.

Part of Nature Communications, 2026

• DOI for Heterogenous microglial reactivity contrasts with stable vascular transcriptional programs in mouse models of Alzheimer's, CADASIL, and Traumatic Brain Injury
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Nerve growth factor responsive elements modulate immune cell inflammation and are dysregulated in an Alzheimer's disease mouse model

Gera, Ruchi; Mocci, Giuseppe; Tambaro, Simone; Vanlandewijck, Michael et al.

Part of Frontiers in Immunology, 2026

• DOI for Nerve growth factor responsive elements modulate immune cell inflammation and are dysregulated in an Alzheimer's disease mouse model
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A comprehensive molecular atlas of the mesenchymal cell types in the mouse liver

Pietilä, Riikka; Genové, Guillem; Mocci, Giuseppe; Miao, Yuyang et al.

Part of EMBO Reports, p. 5326-5359, 2025

• DOI for A comprehensive molecular atlas of the mesenchymal cell types in the mouse liver
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Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

Sukhavasi, Katyayani; Mocci, Giuseppe; Ma, Lijiang; Hodonsky, Chani J. et al.

Part of Nature Cardiovascular Research, p. 412-432, 2025

• DOI for Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques
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A reference protein atlas of the adult mouse brain vasculature

He, Liqun; Johansson, Henrik J.; Vazquez-Liebanas, Elisa; Liu, Jianping et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2026

• DOI for A reference protein atlas of the adult mouse brain vasculature
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Heterogenous microglial reactivity contrasts with stable vascular transcriptional programs in mouse models of Alzheimer's, CADASIL, and Traumatic Brain Injury

Bjørnholm, K. D.; Li, H.; Del Gaudio, F.; Mocci, G. et al.

Part of Nature Communications, 2026

• DOI for Heterogenous microglial reactivity contrasts with stable vascular transcriptional programs in mouse models of Alzheimer's, CADASIL, and Traumatic Brain Injury
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Nerve growth factor responsive elements modulate immune cell inflammation and are dysregulated in an Alzheimer's disease mouse model

Gera, Ruchi; Mocci, Giuseppe; Tambaro, Simone; Vanlandewijck, Michael et al.

Part of Frontiers in Immunology, 2026

• DOI for Nerve growth factor responsive elements modulate immune cell inflammation and are dysregulated in an Alzheimer's disease mouse model
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A comprehensive molecular atlas of the mesenchymal cell types in the mouse liver

Pietilä, Riikka; Genové, Guillem; Mocci, Giuseppe; Miao, Yuyang et al.

Part of EMBO Reports, p. 5326-5359, 2025

• DOI for A comprehensive molecular atlas of the mesenchymal cell types in the mouse liver
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Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

Sukhavasi, Katyayani; Mocci, Giuseppe; Ma, Lijiang; Hodonsky, Chani J. et al.

Part of Nature Cardiovascular Research, p. 412-432, 2025

• DOI for Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques
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Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage

Vázquez-Liébanas, Elisa; Mocci, Giuseppe; Li, Weihan; Laviña, Bàrbara et al.

Part of Cell Reports, 2024

• DOI for Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage
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A brain-specific angiogenic mechanism enabled by tip cell specialization

Schevenels, Giel; Cabochette, Pauline; America, Michelle; Vandenborne, Arnaud et al.

Part of Nature, p. 863-871, 2024

• DOI for A brain-specific angiogenic mechanism enabled by tip cell specialization
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A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature

Bjornholm, Katrine Dahl; Del Gaudio, Francesca; Li, Hao; Li, Weihan et al.

Part of Cell Reports Methods, 2023

• DOI for A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature

Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

Petkova, Milena; Kraft, Marle; Stritt, Simon; Martinez-Corral, Ines et al.

Part of Journal of Experimental Medicine, 2023

• DOI for Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation
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Molecular anatomy of adult mouse leptomeninges

Pietilä, Riikka; Del Gaudio, Francesca; He, Liqun; Vázquez-Liébanas, Elisa et al.

Part of Neuron, 2023

• DOI for Molecular anatomy of adult mouse leptomeninges
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A single-cell transcriptomic inventory of murine smooth muscle cells

Muhl, Lars; Mocci, Giuseppe; Pietilä, Riikka; Liu, Jianping et al.

Part of Developmental Cell, p. 2426-+, 2022

• DOI for A single-cell transcriptomic inventory of murine smooth muscle cells
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The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research

Muhl, Lars; He, Liqun; Sun, Ying; Andaloussi Mäe, Maarja et al.

Part of Stem Cell Reports, p. 1089-1104, 2022

• DOI for The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research

CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells

Somuncular, Ece; Hauenstein, Julia; Khalkar, Prajakta; Johansson, Anne-Sofie et al.

Part of Stem Cell Reports, p. 1546-1560, 2022

• DOI for CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells
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ADAMTS18⁺ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels

Bernier-Latmani, Jeremiah; Mauri, Cristina; Marcone, Rachel; Renevey, Francois et al.

Part of Nature Communications, 2022

• DOI for ADAMTS18⁺ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels
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Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

Mäe, Maarja Andaloussi; He, Liqun; Nordling, Sofia; Vazquez-Liebanas, Elisa et al.

Part of Circulation Research, 2021

• DOI for Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression

Wu, Dan; Wang, Sailan; Oliveira, Daniel V.; Del Gaudio, Francesca et al.

Part of Disease Models and Mechanisms, 2021

• DOI for The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression
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Integrative discovery of treatments for high-risk neuroblastoma

Almstedt, Elin; Elgendy, Ramy; Hekmati, Neda; Rosén, Emil et al.

Part of Nature Communications, 2020

• DOI for Integrative discovery of treatments for high-risk neuroblastoma
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Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

Muhl, Lars; Genove, Guillem; Leptidis, Stefanos; Liu, Jianping et al.

Part of Nature Communications, 2020

• DOI for Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
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A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature

Xiang, Menglan; Grosso, Ruben Adrian; Takeda, Akira; Pan, Junliang et al.

Part of Frontiers in Cardiovascular Medicine, 2020

• DOI for A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature
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Astrocyte-microglial association and matrix composition are common events in the natural history of primary familial brain calcification

Nahar, Khayrun; Lebouvier, Thibaud; Andaloussi Mäe, Maarja; Konzer, Anne et al.

Part of Brain Pathology, p. 446-464, 2020

• DOI for Astrocyte-microglial association and matrix composition are common events in the natural history of primary familial brain calcification
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Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

Engelbrecht, Eric; Levesque, Michel; He, Liqun; Vanlandewijck, Michael et al.

Part of eLIFE, 2020

• DOI for Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
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The protein kinase SIK downregulates the polarity protein Par3

Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta; Mahzabin, Tanzila et al.

Part of Oncotarget, p. 5716-5735, 2018

• DOI for The protein kinase SIK downregulates the polarity protein Par3

Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier

Mäe, Maarja Andaloussi; Li, Tian; Bertuzzi, Giacomo; Raschperger, Elisabeth et al.

Part of Scientific Reports, 2018

• DOI for Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier
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Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice

Loganathan, Krishnapriya; Salem Said, Ebtisam; Winterrowd, Emily; Orebrand, Martina et al.

Part of PLOS ONE, 2018

• DOI for Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice
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A molecular atlas of cell types and zonation in the brain vasculature

Vanlandewijck, Michael; He, Liqun; Mäe, Maarja Andaloussi; Andrae, Johanna et al.

Part of Nature, p. 475-480, 2018

• DOI for A molecular atlas of cell types and zonation in the brain vasculature

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

He, Liqun; Vanlandewijck, Michael; Mäe, Maarja Andaloussi; Andrae, Johanna et al.

Part of Scientific Data, 2018

• DOI for Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types
• Download full text (pdf) of Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

Analysis of the brain mural cell transcriptome

He, Liqun; Vanlandewijck, Michael; Raschperger, Elisabeth; Mae, Maarja Andaloussi et al.

Part of Scientific Reports, 2016

• DOI for Analysis of the brain mural cell transcriptome
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Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation

Carthy, Jon M.; Stoeter, Martin; Bellomo, Claudia; Vanlandewijck, Michael et al.

Part of Scientific Reports, 2016

• DOI for Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation
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Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium

Niaudet, Colin; Hofmann, Jennifer J.; Mae, Maarja A.; Jung, Bongnam et al.

Part of PLOS ONE, 2015

• DOI for Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium

Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification

Vanlandewijck, Michael; Lebouvier, Thibaud; Mae, Maarja Andaloussi; Nahar, Khayrun et al.

Part of PLOS ONE, 2015

• DOI for Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification
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Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

Dahl, Markus; Maturi, Varun; Lönn, Peter; Papoutsoglou, Panagiotis et al.

Part of PLOS ONE, 2014

• DOI for Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling
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Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase

Lönn, Peter; Vanlandewijck, Michael; Raja, Erna; Kowanetz, Marcin et al.

Part of Journal of Biological Chemistry, p. 12867-12878, 2012

• DOI for Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase

TGFβ induces SIK to negatively regulate type I receptor kinase signaling

Kowanetz, Marcin; Lönn, Peter; Vanlandewijck, Michael; Kowanetz, Katarzyna et al.

Part of Journal of Cell Biology, p. 655-662, 2008

• DOI for TGFβ induces SIK to negatively regulate type I receptor kinase signaling

Notch signaling is necessary for epithelial growth arrest by TGF-beta

Niimi, Hideki; Pardali, Katerina; Vanlandewijck, Michael; Heldin, Carl-Henrik et al.

Part of Journal of Cell Biology, p. 695-707, 2007

• DOI for Notch signaling is necessary for epithelial growth arrest by TGF-beta

Heterogeneity and plasticity in healthy and atherosclerotic vasculature explored by single-cell sequencing

van Kuijk, Kim; Kuppe, Christoph; Betsholtz, Christer; Vanlandewijck, Michael et al.

Part of Cardiovascular Research, p. 1705-1715, 2019

• DOI for Heterogeneity and plasticity in healthy and atherosclerotic vasculature explored by single-cell sequencing

Regulation of EMT by TGFβ in cancer

Heldin, Carl-Henrik; Vanlandewijck, Michael; Moustakas, Aristidis

Part of FEBS Letters, p. 1959-1970, 2012

• DOI for Regulation of EMT by TGFβ in cancer

Diversification of TGF-β Signaling in Homeostasis and Disease

Vanlandewijck, Michael

2011

• Download full text (pdf) of Diversification of TGF-β Signaling in Homeostasis and Disease

SIK phosphorylates and degrades Par3 to mediate tight junction disassembly during epithelial-mesenchymal transition

Vanlandewijck, Michael; Lomnytska, Marta; Busch, Christer; Heldin, Carl-Henrik et al.

2011

Angiopoietin 2 is a region-specific regulator of cerebrovascular architecture and blood-brain barrier function.

Li, Weihan; Vázquez-Liébanas, Elisa; Fébrissy, Channaëlle; Sauvé, Florent et al.