Paul O'Callaghan

The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

Sanchez, Gonzalo; Incedal, Tugce Ceren; Prada, Juan; O'Callaghan, Paul et al.

Part of Journal of Cell Biology, 2023

• DOI for The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling
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Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels

Echeverri Correa, Estefania; Skjöldebrand, Charlotte; O'Callaghan, Paul; Palmquist, Anders et al.

Part of Biomaterials Science, p. 3144-3158, 2023

• DOI for Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels
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Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells

O'Callaghan, Paul; Engberg, Adam; Eriksson, Olle; Fatsis-Kavalopoulos, Nikos et al.

Part of Journal of Cell Science, 2022

• DOI for Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells
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Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates

Rostami, Jinar; Mothes, Tobias; Kolahdouzan, Mahshad; Eriksson, Olle et al.

Part of Journal of Neuroinflammation, 2021

• DOI for Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates
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An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting

Engberg, Adam; Stelzl, Christina; Eriksson, Olle; O'Callaghan, Paul et al.

Part of Scientific Reports, 2021

• DOI for An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting
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Modular microfluidic systems cast from 3D-printed molds for imaging leukocyte adherence to differentially treated endothelial cultures

Hernández Vera, Rodrigo; O'Callaghan, Paul; Fatsis-Kavalopoulos, Nikos; Kreuger, Johan

Part of Scientific Reports, 2019

• DOI for Modular microfluidic systems cast from 3D-printed molds for imaging leukocyte adherence to differentially treated endothelial cultures
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Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution

Fatsis-Kavalopoulos, Nikos; O'Callaghan, Paul; Xie, Beichen; Hernández Vera, Rodrigo et al.

Part of Lab on a Chip, p. 1071-1081, 2019

• DOI for Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution
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Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

O'Callaghan, Paul; Li, Jin-Ping; Lannfelt, Lars; Lindahl, Ulf et al.

Part of Journal of Biological Chemistry, p. 14904-14914, 2015

• DOI for Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

Noborn, Fredrik; O'Callaghan, Paul; Hermansson, Erik; Zhang, Xiao et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 5584-5589, 2011

• DOI for Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells

O'Callaghan, Paul; Sandwall, Elina; Li, Jin-Ping; Yu, Hong et al.

Part of Brain Pathology, p. 548-561, 2008

• DOI for Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells

“Blue Light, Camera, Action!”

O'Callaghan, Paul; Idevall Hagren, Olof

Part of ACS Central Science, p. 514-516, 2024

• DOI for “Blue Light, Camera, Action!”

The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

Sanchez, Gonzalo; Incedal, Tugce Ceren; Prada, Juan; O'Callaghan, Paul et al.

Part of Journal of Cell Biology, 2023

• DOI for The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling
• Download full text (pdf) of The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells

Degerstedt, Oliver; O'Callaghan, Paul; Lerma Clavero, Ada; Gråsjö, Johan et al.

Part of Drug Delivery and Translational Research, p. 970-983, 2023

• DOI for Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
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Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels

Echeverri Correa, Estefania; Skjöldebrand, Charlotte; O'Callaghan, Paul; Palmquist, Anders et al.

Part of Biomaterials Science, p. 3144-3158, 2023

• DOI for Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels
• Download full text (pdf) of Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels

In vitro 3D model for monitoring glial cell responses to particles and ions released from spinal implants

Echeverri Correa, Estefania; O'Callaghan, Paul; Kreuger, Johan; Persson, Cecilia

2023

“Blue Light, Camera, Action!”

O'Callaghan, Paul; Idevall Hagren, Olof

Part of ACS Central Science, p. 514-516, 2024

• DOI for “Blue Light, Camera, Action!”

The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

Sanchez, Gonzalo; Incedal, Tugce Ceren; Prada, Juan; O'Callaghan, Paul et al.

Part of Journal of Cell Biology, 2023

• DOI for The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling
• Download full text (pdf) of The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells

Degerstedt, Oliver; O'Callaghan, Paul; Lerma Clavero, Ada; Gråsjö, Johan et al.

Part of Drug Delivery and Translational Research, p. 970-983, 2023

• DOI for Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
• Download full text (pdf) of Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells

Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels

Echeverri Correa, Estefania; Skjöldebrand, Charlotte; O'Callaghan, Paul; Palmquist, Anders et al.

Part of Biomaterials Science, p. 3144-3158, 2023

• DOI for Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels
• Download full text (pdf) of Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels

Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

de la Rosa, Andres; Metzendorf, Nicole G.; Morrison, Jamie; Faresjö, Rebecca et al.

Part of Scientific Reports, 2022

• DOI for Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3
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Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells

O'Callaghan, Paul; Engberg, Adam; Eriksson, Olle; Fatsis-Kavalopoulos, Nikos et al.

Part of Journal of Cell Science, 2022

• DOI for Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells
• Download full text (pdf) of Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells

Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates

Rostami, Jinar; Mothes, Tobias; Kolahdouzan, Mahshad; Eriksson, Olle et al.

Part of Journal of Neuroinflammation, 2021

• DOI for Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates
• Download full text (pdf) of Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates

Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease

Zhang, Xiao; O'Callaghan, Paul; Li, Honglian; Tan, Ying-Xia et al.

Part of Acta neuropathologica communications, 2021

• DOI for Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain: relevance to Alzheimer's disease
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An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting

Engberg, Adam; Stelzl, Christina; Eriksson, Olle; O'Callaghan, Paul et al.

Part of Scientific Reports, 2021

• DOI for An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting
• Download full text (pdf) of An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Syvänen, Stina; O'Callaghan, Paul; Sehlin, Dag

Part of Translational Neurodegeneration, 2020

• DOI for SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease
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Modular microfluidic systems cast from 3D-printed molds for imaging leukocyte adherence to differentially treated endothelial cultures

Hernández Vera, Rodrigo; O'Callaghan, Paul; Fatsis-Kavalopoulos, Nikos; Kreuger, Johan

Part of Scientific Reports, 2019

• DOI for Modular microfluidic systems cast from 3D-printed molds for imaging leukocyte adherence to differentially treated endothelial cultures
• Download full text (pdf) of Modular microfluidic systems cast from 3D-printed molds for imaging leukocyte adherence to differentially treated endothelial cultures

Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution

Fatsis-Kavalopoulos, Nikos; O'Callaghan, Paul; Xie, Beichen; Hernández Vera, Rodrigo et al.

Part of Lab on a Chip, p. 1071-1081, 2019

• DOI for Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution
• Download full text (pdf) of Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution

Modeling the structural implications of an alternatively spliced Exoc3l2, a paralog of the tunneling nanotube-forming M-Sec

O'Callaghan, Paul; Zarb, Yvette; Noborn, Fredrik; Kreuger, Johan

Part of PLOS ONE, 2018

• DOI for Modeling the structural implications of an alternatively spliced Exoc3l2, a paralog of the tunneling nanotube-forming M-Sec
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Vascular sprouts induce local attraction of proangiogenic neutrophils

Christoffersson, Gustaf; Lomei, Jalal; O'Callaghan, Paul; Kreuger, Johan et al.

Part of Journal of Leukocyte Biology, p. 741-751, 2017

• DOI for Vascular sprouts induce local attraction of proangiogenic neutrophils

FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation

Heldin, Johan; O'Callaghan, Paul; Hernández Vera, Rodrigo; Fredlund Fuchs, Peder et al.

Part of Cellular Signalling, p. 125-132, 2017

• DOI for FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation

Failure to Genotype: A Cautionary Note on an Elusive loxP Sequence

Kreuger, Johan; O'Callaghan, Paul

Part of PLOS ONE, 2016

• DOI for Failure to Genotype: A Cautionary Note on an Elusive loxP Sequence
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Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

O'Callaghan, Paul; Li, Jin-Ping; Lannfelt, Lars; Lindahl, Ulf et al.

Part of Journal of Biological Chemistry, p. 14904-14914, 2015

• DOI for Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

O'Callaghan, Paul; Noborn, Fredrik; Sehlin, Dag; Li, Jin-ping et al.

Part of Amyloid, p. 76-87, 2014

• DOI for Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Kasza, Zsolt; Fredlund Fuchs, Peder; Tamm, Christoffer; Eriksson, Anna S. et al.

Part of Journal of Biological Chemistry, p. 25956-25963, 2013

• DOI for MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-beta in murine brain

Zhang, Xiao; Wang, Bo; O'Callaghan, Paul; Hjertstrom, Elina et al.

Part of Acta Neuropathologica, p. 465-478, 2012

• DOI for Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-beta in murine brain

Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

Noborn, Fredrik; O'Callaghan, Paul; Hermansson, Erik; Zhang, Xiao et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 5584-5589, 2011

• DOI for Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

Sandwall, Elina; O'Callaghan, Paul; Zhang, Xiao; Lindahl, Ulf et al.

Part of Glycobiology, p. 533-541, 2010

• DOI for Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells

O'Callaghan, Paul; Sandwall, Elina; Li, Jin-Ping; Yu, Hong et al.

Part of Brain Pathology, p. 548-561, 2008

• DOI for Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells

Heparan Sulfate Proteoglycans as Relays of Neuroinflammation

O'Callaghan, Paul; Zhang, Xiao; Li, Jin-Ping

Part of Journal of Histochemistry and Cytochemistry, p. 305-319, 2018

• DOI for Heparan Sulfate Proteoglycans as Relays of Neuroinflammation

Animal models of amyloid-β-related pathologies in Alzheimer’s disease

Philipson, Ola; Lord, Anna; Gumucio, Astrid; O'Callaghan, Paul et al.

Part of The FEBS Journal, p. 1389-1409, 2010

• DOI for Animal models of amyloid-β-related pathologies in Alzheimer’s disease

Heparan Sulfate in the Amyloidosis and Inflammation of Alzheimer’s Disease

O'Callaghan, Paul

2011

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In vitro 3D model for monitoring glial cell responses to particles and ions released from spinal implants

Echeverri Correa, Estefania; O'Callaghan, Paul; Kreuger, Johan; Persson, Cecilia

2023

Towards a bioprinted spinal cord model for monitoring cell responses to particles and ions released from spinal implants

Echeverri Correa, Estefania; O'Callaghan, Paul; Kreuger, Johan; Persson, Cecilia

Part of TERMIS 2023 – European ChapterManchester Central Conference Centre Manchester, UK March 28–31, 2023, 2023

• DOI for Towards a bioprinted spinal cord model for monitoring cell responses to particles and ions released from spinal implants

Impact of particles derived from spinal implant materials on glial survival and activation

Echeverri Correa, Estefania; O'Callaghan, Paul; Ferraz, Natalia; Hulsart Billström, Gry et al.