Carina Farah Mugal
Affiliated Researcher at Department of Ecology and Genetics; Evolutionary Biology
- Telephone:
- +46 18 471 64 66
- E-mail:
- Carina.Mugal@ebc.uu.se
- Visiting address:
- Evolutionsbiologiskt Centrum
Norbyvägen 18D
752 36 UPPSALA - Postal address:
- Evolutionsbiologiskt centrum
Norbyvägen 18D
752 36 UPPSALA
Short presentation
My main research interest lies in understanding patterns of molecular evolution, such as genomic signatures of natural selection, mutation bias and GC-biased gene conversion. In particular, I focus on variation in these patterns among species, across the genome and among different functional elements. In order to explore these questions, I use a multi-disciplinary approach relying on mathematical modeling and comparative genomics, where I primarily use Ficedula flycatchers as a model organism.
Keywords
- molecular evolution
- theoretical population genetics
- stochastic modeling
- population genomics
- gene regulatory evolution
Biography
May 2022 – present
Guest Researcher (10%)
Department of Ecology and Genetics
Uppsala University, Sweden
May 2022 – present
CNRS Researcher
Laboratory of Biometry and Evolutionary Biology (LBBE)
University of Lyon 1, France
July 2017 – April 2022
Researcher
Department of Ecology and Genetics
Uppsala University, Sweden
September 2013 – June 2017
Postdoctoral Researcher
Department of Ecology and Genetics
Uppsala University, Sweden
November 2008 – June 2013
PhD studies in evolutionary genetics
Department of Ecology and Genetics
Uppsala University, Sweden
July 2011 – February 2012
Research internship
Department of Computational Molecular Biology
Max Planck Institute, Berlin
March 2005 – April 2008
Undergraduate studies in theoretical chemistry
Department of Chemistry
University of Graz, Austria

Publications
Selection of publications
A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size
Part of Genome Biology and Evolution, 2022
- DOI for A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size
- Download full text (pdf) of A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size
Part of Evolution, p. 2179-2196, 2021
- DOI for Positive selection plays a major role in shaping signatures of differentiation across the genomic landscape of two independent Ficedula flycatcher species pairs
- Download full text (pdf) of Positive selection plays a major role in shaping signatures of differentiation across the genomic landscape of two independent Ficedula flycatcher species pairs
Part of Genome Research, p. 1727-1739, 2020
- DOI for Tissue-specific patterns of regulatory changes underlying gene expression differences among Ficedula flycatchers and their naturally occurring F1 hybrids
- Download full text (pdf) of Tissue-specific patterns of regulatory changes underlying gene expression differences among Ficedula flycatchers and their naturally occurring F1 hybrids
GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes
Part of Genome Biology, 2019
- DOI for GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes
- Download full text (pdf) of GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes
Part of Molecular Ecology, p. 4158-4172, 2017
- DOI for Whole-genome patterns of linkage disequilibrium across flycatcher populations clarify the causes and consequences of fine-scale recombination rate variation in birds
- Download full text (pdf) of Whole-genome patterns of linkage disequilibrium across flycatcher populations clarify the causes and consequences of fine-scale recombination rate variation in birds
The non-equilibrium allele frequency spectrum in a Poisson random field framework
Part of Theoretical Population Biology, p. 51-64, 2016
Recent publications
A Wright-Fisher graph model and the impact of directional selection on genetic variation
Part of Theoretical Population Biology, p. 13-24, 2024
- DOI for A Wright-Fisher graph model and the impact of directional selection on genetic variation
- Download full text (pdf) of A Wright-Fisher graph model and the impact of directional selection on genetic variation
Part of BMC Biology, 2024
- DOI for Regulatory and evolutionary impact of DNA methylation in two songbird species and their naturally occurring F1 hybrids
- Download full text (pdf) of Regulatory and evolutionary impact of DNA methylation in two songbird species and their naturally occurring F1 hybrids
Part of Proceedings of the Royal Society of London. Biological Sciences, 2024
A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size
Part of Genome Biology and Evolution, 2022
- DOI for A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size
- Download full text (pdf) of A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size
2022
- DOI for Single-Cell Transcriptomics reveals relaxed evolutionary constraint of spermatogenesis in two passerine birds as compared to mammals
- Download full text (pdf) of Single-Cell Transcriptomics reveals relaxed evolutionary constraint of spermatogenesis in two passerine birds as compared to mammals
All publications
Articles in journal
A Wright-Fisher graph model and the impact of directional selection on genetic variation
Part of Theoretical Population Biology, p. 13-24, 2024
- DOI for A Wright-Fisher graph model and the impact of directional selection on genetic variation
- Download full text (pdf) of A Wright-Fisher graph model and the impact of directional selection on genetic variation
Part of BMC Biology, 2024
- DOI for Regulatory and evolutionary impact of DNA methylation in two songbird species and their naturally occurring F1 hybrids
- Download full text (pdf) of Regulatory and evolutionary impact of DNA methylation in two songbird species and their naturally occurring F1 hybrids
Part of Proceedings of the Royal Society of London. Biological Sciences, 2024
A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size
Part of Genome Biology and Evolution, 2022
- DOI for A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size
- Download full text (pdf) of A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size
Part of Genome Biology and Evolution, 2021
- DOI for The Effects of GC-Biased Gene Conversion on Patterns of Genetic Diversity among and across Butterfly Genomes
- Download full text (pdf) of The Effects of GC-Biased Gene Conversion on Patterns of Genetic Diversity among and across Butterfly Genomes
Part of Evolution, p. 2179-2196, 2021
- DOI for Positive selection plays a major role in shaping signatures of differentiation across the genomic landscape of two independent Ficedula flycatcher species pairs
- Download full text (pdf) of Positive selection plays a major role in shaping signatures of differentiation across the genomic landscape of two independent Ficedula flycatcher species pairs
Part of Molecular biology and evolution, p. 260-279, 2020
- DOI for Polymorphism Data Assist Estimation of the Nonsynonymous over Synonymous Fixation Rate Ratio omega for Closely Related Species
- Download full text (pdf) of Polymorphism Data Assist Estimation of the Nonsynonymous over Synonymous Fixation Rate Ratio omega for Closely Related Species
Part of Genome Research, p. 1727-1739, 2020
- DOI for Tissue-specific patterns of regulatory changes underlying gene expression differences among Ficedula flycatchers and their naturally occurring F1 hybrids
- Download full text (pdf) of Tissue-specific patterns of regulatory changes underlying gene expression differences among Ficedula flycatchers and their naturally occurring F1 hybrids
GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes
Part of Genome Biology, 2019
- DOI for GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes
- Download full text (pdf) of GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes
Part of Molecular biology and evolution, p. 2475-2486, 2018
- DOI for Biased Inference of Selection Due to GC-Biased Gene Conversion and the Rate of Protein Evolution in Flycatchers When Accounting for It
- Download full text (pdf) of Biased Inference of Selection Due to GC-Biased Gene Conversion and the Rate of Protein Evolution in Flycatchers When Accounting for It
Positive selection on human gamete-recognition genes
Part of PeerJ, 2018
- DOI for Positive selection on human gamete-recognition genes
- Download full text (pdf) of Positive selection on human gamete-recognition genes
Part of Molecular Ecology, p. 3572-3581, 2018
- DOI for Sex-biased gene expression, sexual antagonism and levels of genetic diversity in the collared flycatcher (Ficedula albicollis) genome
- Download full text (pdf) of Sex-biased gene expression, sexual antagonism and levels of genetic diversity in the collared flycatcher (Ficedula albicollis) genome
Part of Molecular Ecology, p. 4158-4172, 2017
- DOI for Whole-genome patterns of linkage disequilibrium across flycatcher populations clarify the causes and consequences of fine-scale recombination rate variation in birds
- Download full text (pdf) of Whole-genome patterns of linkage disequilibrium across flycatcher populations clarify the causes and consequences of fine-scale recombination rate variation in birds
Part of Molecular Ecology Resources, p. 586-597, 2017
- DOI for Genomic distribution and estimation of nucleotide diversity in natural populations: perspectives from the collared flycatcher (Ficedula albicollis) genome
- Download full text (pdf) of Genomic distribution and estimation of nucleotide diversity in natural populations: perspectives from the collared flycatcher (Ficedula albicollis) genome
Part of Proceedings of the Royal Society of London. Biological Sciences, 2017
Part of Molecular biology and evolution, p. 216-227, 2016
- DOI for Recombination Rate Variation Modulates Gene Sequence Evolution Mainly via GC-Biased Gene Conversion, Not Hill-Robertson Interference, in an Avian System
- Download full text (pdf) of Recombination Rate Variation Modulates Gene Sequence Evolution Mainly via GC-Biased Gene Conversion, Not Hill-Robertson Interference, in an Avian System
Part of PLOS Genetics, 2016
- DOI for High-Resolution Mapping of Crossover and Non-crossover Recombination Events by Whole-Genome Re-sequencing of an Avian Pedigree
- Download full text (pdf) of High-Resolution Mapping of Crossover and Non-crossover Recombination Events by Whole-Genome Re-sequencing of an Avian Pedigree
Divergence in gene expression within and between two closely related flycatcher species
Part of Molecular Ecology, p. 2015-2028, 2016
- DOI for Divergence in gene expression within and between two closely related flycatcher species
- Download full text (pdf) of Divergence in gene expression within and between two closely related flycatcher species
Selection on coevolving human gamete recognition genes
Part of Integrative and Comparative Biology, 2016
The non-equilibrium allele frequency spectrum in a Poisson random field framework
Part of Theoretical Population Biology, p. 51-64, 2016
Part of Bioessays, p. 1317-1326, 2015
Evolutionary Consequences of DNA Methylation on the GC Content in Vertebrate Genomes
Part of G3, p. 441-447, 2015
- DOI for Evolutionary Consequences of DNA Methylation on the GC Content in Vertebrate Genomes
- Download full text (pdf) of Evolutionary Consequences of DNA Methylation on the GC Content in Vertebrate Genomes
Part of Genome Research, p. 1656-1665, 2015
- DOI for Linked selection and recombination rate variation drive the evolution of the genomic landscape of differentiation across the speciation continuum of Ficedula flycatchers
- Download full text (pdf) of Linked selection and recombination rate variation drive the evolution of the genomic landscape of differentiation across the speciation continuum of Ficedula flycatchers
Why Time Matters: Codon Evolution and the Temporal Dynamics of dN/dS
Part of Molecular biology and evolution, p. 212-231, 2014
Twisted Signatures of GC-Biased Gene Conversion Embedded in an Evolutionary Stable Karyotype
Part of Molecular biology and evolution, p. 1700-1712, 2013
Part of BMC Genomics, p. 86, 2013
- DOI for Genome-wide analysis in chicken reveals that local levels of genetic diversity are mainly governed by the rate of recombination
- Download full text (pdf) of Genome-wide analysis in chicken reveals that local levels of genetic diversity are mainly governed by the rate of recombination
Part of Genome Biology, 2011
Conservation of Neutral Substitution Rate and Substitutional Asymmetries in Mammalian Genes
Part of Genome Biology and Evolution, p. 19-28, 2010
Molecular evolution of genes in avian genomes
Part of Genome Biology, 2010
Transcription-induced mutational strand bias and its effect on substitution rates in human genes
Part of Molecular biology and evolution, p. 131-142, 2009
Articles, review/survey
Part of Molecular Ecology, p. 4035-4058, 2014
- DOI for A high-density linkage map enables a second-generation collared flycatcher genome assembly and reveals the patterns of avian recombination rate variation and chromosomal evolution
- Download full text (pdf) of A high-density linkage map enables a second-generation collared flycatcher genome assembly and reveals the patterns of avian recombination rate variation and chromosomal evolution
Comprehensive doctoral thesis
Manuscripts (preprints)
2022
- DOI for Single-Cell Transcriptomics reveals relaxed evolutionary constraint of spermatogenesis in two passerine birds as compared to mammals
- Download full text (pdf) of Single-Cell Transcriptomics reveals relaxed evolutionary constraint of spermatogenesis in two passerine birds as compared to mammals
The genomic basis of hybrid male sterility in Ficedula flycatchers
Evidence that genetic drift not adaptation drives fast-Z and large-Z effects in Ficedula flycatchers