Tobias Sjöblom

NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Rameika, Natallia; Tsiara, Ioanna; Zhang, Xiaonan; Haberek, Wawrzyniec et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI for NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
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Prognostic genome and transcriptome signatures in colorectal cancers

Nunes, Luís; Li, Fuqiang; Wu, Meizhen; Luo, Tian et al.

Part of Nature, p. 137-146, 2024

• DOI for Prognostic genome and transcriptome signatures in colorectal cancers

Enhanced classification performance using deep learning based segmentation for pulmonary embolism detection in CT angiography.

Kahraman, Ali Teymur; Fröding, Tomas; Toumpanakis, Dimitrios; Jamtheim Gustafsson, Christian et al.

Part of Heliyon, 2024

• DOI for Enhanced classification performance using deep learning based segmentation for pulmonary embolism detection in CT angiography.
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Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Part of EBioMedicine, 2024

• DOI for Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
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Evaluation of coverage, generalisability and validity of the U-CAN lymphoma biobank in Sweden: A comparison with nationwide registers

Forsgren, Elin; Ekberg, Sara; Smedby, Karin E.; Nylund, Patrick et al.

Part of British Journal of Haematology, p. 1794-1803, 2024

• DOI for Evaluation of coverage, generalisability and validity of the U-CAN lymphoma biobank in Sweden: A comparison with nationwide registers
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NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Rameika, Natallia; Tsiara, Ioanna; Zhang, Xiaonan; Haberek, Wawrzyniec et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI for NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
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Prognostic genome and transcriptome signatures in colorectal cancers

Nunes, Luís; Li, Fuqiang; Wu, Meizhen; Luo, Tian et al.

Part of Nature, p. 137-146, 2024

• DOI for Prognostic genome and transcriptome signatures in colorectal cancers

Enhanced classification performance using deep learning based segmentation for pulmonary embolism detection in CT angiography.

Kahraman, Ali Teymur; Fröding, Tomas; Toumpanakis, Dimitrios; Jamtheim Gustafsson, Christian et al.

Part of Heliyon, 2024

• DOI for Enhanced classification performance using deep learning based segmentation for pulmonary embolism detection in CT angiography.
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Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Part of EBioMedicine, 2024

• DOI for Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
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Evaluation of coverage, generalisability and validity of the U-CAN lymphoma biobank in Sweden: A comparison with nationwide registers

Forsgren, Elin; Ekberg, Sara; Smedby, Karin E.; Nylund, Patrick et al.

Part of British Journal of Haematology, p. 1794-1803, 2024

• DOI for Evaluation of coverage, generalisability and validity of the U-CAN lymphoma biobank in Sweden: A comparison with nationwide registers
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Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer

Nunes, Luís; Mørkved Stenersen, Jakob; Kryeziu, Kushtrim; Sjöblom, Tobias et al.

Part of Molecular Cancer, 2024

• DOI for Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer
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Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer

Hammarström, Klara; Nunes, Luís; Mathot, Lucy; Mezheyeuski, Artur et al.

Part of International Journal of Cancer, p. 40-53, 2024

• DOI for Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer
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Sensitive and Specific Analyses of Colorectal Cancer Recurrence through Multiplex superRCA Mutation Detection in Blood Plasma

Sandberg, Emma; Nunes, Luís; Edqvist, Per-Henrik; Mathot, Lucy et al.

Part of Cancers, 2024

• DOI for Sensitive and Specific Analyses of Colorectal Cancer Recurrence through Multiplex superRCA Mutation Detection in Blood Plasma
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Atypical (non‐V600E) BRAF mutations in metastatic colorectal cancer in population and real‐world cohorts

Österlund, Emerik; Ristimäki, Ari; Mäkinen, Markus J.; Kytölä, Soili et al.

Part of International Journal of Cancer, p. 488-503, 2024

• DOI for Atypical (non‐V600E) BRAF mutations in metastatic colorectal cancer in population and real‐world cohorts
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Signet Ring Cell Colorectal and Appendiceal Cancer: A Small Signet Ring Cell Component Is Also Associated with Poor Outcome

Enblad, Malin; Pál Egerszegi, Péter; Birgisson, Helgi; Sjöblom, Tobias et al.

Part of Cancers, 2023

• DOI for Signet Ring Cell Colorectal and Appendiceal Cancer: A Small Signet Ring Cell Component Is Also Associated with Poor Outcome
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Automated detection, segmentation and measurement of major vessels and the trachea in CT pulmonary angiography

Kahraman, Ali T.; Fröding, Tomas; Toumpanakis, Dimitrios; Sladoje, Nataša et al.

Part of Scientific Reports, 2023

• DOI for Automated detection, segmentation and measurement of major vessels and the trachea in CT pulmonary angiography
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Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Lu, Xi; Zhong, Lei; Lindell, Emma; Veanes, Margus et al.

Part of Cell Death and Disease, 2023

• DOI for Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
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Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells

Kundu, Snehangshu; Nunes, Luís; Adler, Jeremy; Mathot, Lucy et al.

Part of Cell Communication and Signaling, 2023

• DOI for Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells
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Next generation pan-cancer blood proteome profiling using proximity extension assay

Alvez, Maria Bueno; Edfors, Fredrik; von Feilitzen, Kalle; Zwahlen, Martin et al.

Part of Nature Communications, 2023

• DOI for Next generation pan-cancer blood proteome profiling using proximity extension assay
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An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Mezheyeuski, Artur; Backman, Max; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Part of EBioMedicine, 2023

• DOI for An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
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Exact Probability Distribution for the ROC Area under Curve

Ekström, Joakim; Åkerrén Ögren, Jim; Sjöblom, Tobias

Part of Cancers, 2023

• DOI for Exact Probability Distribution for the ROC Area under Curve
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Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity

Zhang, Xiaonan; Akcan, Ece; Correia, Mario S. P.; Rameika, Natallia et al.

Part of Biochemical Pharmacology, 2022

• DOI for Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
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Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Westergren Jakobsson, Amanda; Kundu, Snehangshu; Guo, Jing; Chowdhury, Azazul Islam et al.

Part of Cancers, 2022

• DOI for Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
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Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer.

Gyllensten, Ulf B.; Hedlund-Lindberg, Julia; Svensson, Johanna; Manninen, Johanna et al.

Part of Cancers, 2022

• DOI for Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer.
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KRAS-G12C Mutation in One Real-Life and Three Population-Based Nordic Cohorts of Metastatic Colorectal Cancer

Österlund, Emerik; Ristimaki, Ari; Kytola, Soili; Kuopio, Teijo et al.

Part of Frontiers in Oncology, 2022

• DOI for KRAS-G12C Mutation in One Real-Life and Three Population-Based Nordic Cohorts of Metastatic Colorectal Cancer
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Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples

Zhang, Hua; Polavarapu, Vamsi Krishna; Xing, Pengwei; Zhao, Miao et al.

Part of Genome Research, p. 150-161, 2022

• DOI for Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
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FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers

Zhao, Linxuan; Xing, Pengwei; Polavarapu, Vamsi Krishna; Zhao, Miao et al.

Part of Nucleic Acids Research, 2021

• DOI for FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers
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Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Conway, Louis P. et al.

Part of Journal of Experimental & Clinical Cancer Research, 2021

• DOI for Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
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The Immune Landscape of Colorectal Cancer

Mezheyeuski, Artur; Micke, Patrick; Martin-Bernabe, Alfonso; Backman, Max et al.

Part of Cancers, 2021

• DOI for The Immune Landscape of Colorectal Cancer
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Neoadjuvant rectal (NAR) score: Value evaluating the efficacy of neoadjuvant therapy and prognostic significance after surgery?

Imam, Israa; Hammarström, Klara; Sjöblom, Tobias; Glimelius, Bengt

Part of Radiotherapy and Oncology, p. 70-77, 2021

• DOI for Neoadjuvant rectal (NAR) score: Value evaluating the efficacy of neoadjuvant therapy and prognostic significance after surgery?
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Accurate population-based model for individual prediction of colon cancer recurrence

Osterman, Erik; Ekström, Joakim; Sjöblom, Tobias; Kørner, Hartwig et al.

Part of Acta Oncologica, p. 1241-1249, 2021

• DOI for Accurate population-based model for individual prediction of colon cancer recurrence

A Comprehensive Evaluation of Associations Between Routinely Collected Staging Information and The Response to (Chemo)Radiotherapy in Rectal Cancer

Hammarström, Klara; Imam, Israa; Mezheyeuski, Artur; Ekström, Joakim et al.

Part of Cancers, 2021

• DOI for A Comprehensive Evaluation of Associations Between Routinely Collected Staging Information and The Response to (Chemo)Radiotherapy in Rectal Cancer
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Completeness and accuracy of the registration of recurrences in the Swedish Colorectal Cancer Registry (SCRCR) and an update of recurrence risk in colon cancer

Osterman, Erik; Hammarström, Klara; Imam, Israa; Österlund, Emerik et al.

Part of Acta Oncologica, p. 842-849, 2021

• DOI for Completeness and accuracy of the registration of recurrences in the Swedish Colorectal Cancer Registry (SCRCR) and an update of recurrence risk in colon cancer

Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer

Rendo, Verónica; Kundu, Snehangshu; Rameika, Natallia; Ljungström, Viktor et al.

Part of Scientific Reports, 2020

• DOI for Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer
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Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2

Conway, Louis P.; Rendo, Verónica; Correia, Mario S. P.; Bergdahl, Ingvar A et al.

Part of Angewandte Chemie International Edition, p. 14342-14346, 2020

• DOI for Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2
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Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis

Nunes, Luís; Aasebø, Kristine; Mathot, Lucy; Ljungström, Viktor et al.

Part of Acta Oncologica, p. 417-426, 2020

• DOI for Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis
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Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

Part of Nature Communications, 2020

• DOI for Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
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Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort

Mathioudaki, Argyri; Ljungström, Viktor; Melin, Malin; Arendt, Maja Louise et al.

Part of Scientific Reports, 2020

• DOI for Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort
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Beyond the NCCN Risk Factors in Colon Cancer: An Evaluation in a Swedish Population-Based Cohort

Osterman, Erik; Mezheyeuski, Artur; Sjöblom, Tobias; Glimelius, Bengt

Part of Annals of Surgical Oncology, p. 1036-1045, 2020

• DOI for Beyond the NCCN Risk Factors in Colon Cancer: An Evaluation in a Swedish Population-Based Cohort
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Prognostic Interactions between FAP plus Fibroblasts and CD8a+T Cells in Colon Cancer

Herrera, Mercedes; Mezheyeuski, Artur; Villabona, Lisa; Corvigno, Sara et al.

Part of Cancers, 2020

• DOI for Prognostic Interactions between FAP plus Fibroblasts and CD8a+T Cells in Colon Cancer
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Targeting tumor vulnerabilities associated with loss of heterozygosity

Rendo, Veronica; Stoimenov, Ivaylo; Sjöblom, Tobias

Part of Molecular & Cellular Oncology, 2020

• DOI for Targeting tumor vulnerabilities associated with loss of heterozygosity
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Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression

Larsson, Chatarina; Cordeddu, Lina; Siggens, Lee; Djureinovic, Tatjana et al.

Part of Clinical Epigenetics, 2020

• DOI for Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression
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Determining the use of preoperative (chemo)radiotherapy in primary rectal cancer according to national and international guidelines

Hammarström, Klara; Imam, Israa; Korsavidou Hult, Nafsika; Ekström, Joakim et al.

Part of Radiotherapy and Oncology, p. 106-112, 2019

• DOI for Determining the use of preoperative (chemo)radiotherapy in primary rectal cancer according to national and international guidelines

Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series

Vallon-Christersson, Johan; Häkkinen, Jari; Hegardt, Cecilia; Saal, Lao H. et al.

Part of Scientific Reports, 2019

• DOI for Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series
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Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer

Lundgren, Christine; Bendahl, Pär-Ola; Borg, Åke; Ehinger, Anna et al.

Part of Breast Cancer Research and Treatment, p. 459-467, 2019

• DOI for Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer
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Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer

Mezheyeuski, Artur; Hrynchyk, Ina; Herrera, Mercedes; Karlberg, Mia et al.

Part of British Journal of Cancer, p. 303-311, 2019

• DOI for Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer

U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.

Glimelius, Bengt; Melin, Beatrice; Enblad, Gunilla; Alafuzoff, Irina et al.

Part of Acta Oncologica, p. 187-194, 2018

• DOI for U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
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Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Padhan, Narendra et al.

Part of Genome Medicine, 2018

• DOI for Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Stage distribution utilizing magnetic resonance imaging in an unselected population of primary rectal cancers

Hammarström, Klara; Mezheyeuski, Artur; Korsavidou Hult, Nafsika; Sjöblom, Tobias et al.

Part of European Journal of Surgical Oncology, p. 1858-1864, 2018

• DOI for Stage distribution utilizing magnetic resonance imaging in an unselected population of primary rectal cancers

Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients

Mezheyeuski, Artur; Bergsland, Christian Holst; Backman, Max; Djureinovic, Dijana et al.

Part of Journal of Pathology, p. 421-431, 2018

• DOI for Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients

VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival

Morin, Eric; Sjöberg, Elin; Tjomsland, Vegard; Testini, Chiara et al.

Part of Journal of Pathology, p. 311-322, 2018

• DOI for VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival
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Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome

Mezheyeuski, Artur; Bergsland, Christian; Backman, Max; Sjöblom, Tobias et al.

Part of CANCER IMMUNOLOGY RESEARCH, 2018

• DOI for Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome

Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition

Larsson, Chatarina; Ali, Muhammad Akhtar; Djureinovic, Tatjana; Lindroth, Anders M. et al.

Part of BMC Cancer, 2017

• DOI for Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition
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Somatic PRDM2 c.4467delA mutations in colorectal cancers control histone methylation and tumor growth

Pandzic, Tatjana; Rendo, Verónica; Lim, Jinyeong; Larsson, Chatarina et al.

Part of Oncotarget, p. 98646-98659, 2017

• DOI for Somatic PRDM2 c.4467delA mutations in colorectal cancers control histone methylation and tumor growth

Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

Karlsson, Henning; Fryknäs, Mårten; Strese, Sara; Gullbo, Joachim et al.

Part of Oncotarget, p. 30217-30234, 2017

• DOI for Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity
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Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy

Kühnemund, Malte; Wei, Qingshan; Darai, Evangelia; Wang, Yingjie et al.

Part of Nature Communications, 2017

• DOI for Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy
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A new distance measure for non-identical data with application to image classification

Swaminathan, Muthukaruppan; Yadav, Pankaj Kumar; Piloto, Obdulio; Sjöblom, Tobias et al.

Part of Pattern Recognition, p. 384-396, 2017

• DOI for A new distance measure for non-identical data with application to image classification

Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer

Mathot, Lucy; Kundu, Snehangshu; Ljungström, Viktor; Svedlund, Jessica et al.

Part of Cancer Research, p. 1730-1740, 2017

• DOI for Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer

A pathology atlas of the human cancer transcriptome

Uhlen, Mathias; Zhang, Cheng; Lee, Sunjae; Sjöstedt, Evelina et al.

Part of Science, 2017

• DOI for A pathology atlas of the human cancer transcriptome

Mutanome engineered RNA immuno-therapy (MERIT) for patients with triple negative breast cancer

Frenzel, K.; Heesen, L.; Bolte, S.; Bukur, V. et al.

Part of Annals of Oncology, 2017

• DOI for Mutanome engineered RNA immuno-therapy (MERIT) for patients with triple negative breast cancer

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

Ljungström, Viktor; Cortese, Diego; Young, Emma; Pandzic, Tatjana et al.

Part of Blood, p. 1007-1016, 2016

• DOI for Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia

Pandzic, Tatjana; Larsson, Jimmy; He, Liqun; Kundu, Snehangshu et al.

Part of Clinical Cancer Research, p. 6217-6227, 2016

• DOI for Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia

Mutanome Engineered RNA Immunotherapy (MERIT)

Sahin, Ugur; Zitvogel, Laurence; Andre, Fabrice; Thielemans, Kris et al.

Part of HUMAN GENE THERAPY CLINICAL DEVELOPMENT, p. 84-86, 2015

• DOI for Mutanome Engineered RNA Immunotherapy (MERIT)

Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells

Ali, Muhammad Akhtar; Younis, Shady; Wallerman, Ola; Gupta, Rajesh et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 7743-7748, 2015

• DOI for Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells

DISSECTING RESISTANCE MECHANISMS IN CHRONIC LYMPHOCYTIC LEUKEMIA USING WHOLE-EXOME SEQUENCING: IMPACT OF RECURRENT RPS15 MUTATIONS ON P53 DYSREGULATION

Ljungström, Viktor; Cortese, Diego; Young, Emma; Pandzic, Tatjana et al.

Part of Haematologica, p. 10-11, 2015

Tumor Vessel Up-Regulation of INSR Revealed by Single-Cell Expression Analysis of the Tyrosine Kinome and Phosphatome in Human Cancers

Kiflemariam, Sara; Ljungström, Viktor; Pontén, Fredrik; Sjöblom, Tobias

Part of American Journal of Pathology, p. 1600-1609, 2015

• DOI for Tumor Vessel Up-Regulation of INSR Revealed by Single-Cell Expression Analysis of the Tyrosine Kinome and Phosphatome in Human Cancers

Computational and molecular tools for scalable rAAV-mediated genome editing

Stoimenov, Ivaylo; Ali, Muhammad Akhtar; Pandzic, Tatjana; Sjöblom, Tobias

Part of Nucleic Acids Research, 2015

• DOI for Computational and molecular tools for scalable rAAV-mediated genome editing

The Mutanome Engineered RNA Immuno-Therapy (MERIT) project

Heesch, Sandra; Britten, Cedrik M.; Bukur, Valesca; Buck, Janina et al.

Part of Cancer Research, 2015

• DOI for The Mutanome Engineered RNA Immuno-Therapy (MERIT) project

Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15

Bruzzese, Francesca; Hagglof, Christina; Leone, Alessandra; Sjoberg, Elin et al.

Part of Cancer Research, p. 3408-3417, 2014

• DOI for Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15

In situ sequencing identifies TMPRSS2-ERG fusion transcripts, somatic point mutations and gene expression levels in prostate cancers

Kiflemariam, Sara; Mignardi, Marco; Ali, Muhammad Akhtar; Bergh, Anders et al.

Part of Journal of Pathology, p. 253-261, 2014

• DOI for In situ sequencing identifies TMPRSS2-ERG fusion transcripts, somatic point mutations and gene expression levels in prostate cancers

1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer

Mayrhofer, Markus; Kultima, Hanna Göransson; Birgisson, Helgi; Sundström, Magnus et al.

Part of BMC Cancer, p. 872, 2014

• DOI for 1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer
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A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Kashif, Muhammad; Andersson, Claes; Åberg, Magnus; Nygren, Peter et al.

Part of Molecular Cancer Therapeutics, p. 1964-1976, 2014

• DOI for A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing

Jiao, Xiang; Hooper, Sean D.; Djureinovic, Tatjana; Larsson, Chatarina et al.

Part of BMC Genomics, 2013

• DOI for Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing
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In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics

Grundberg, Ida; Kiflemariam, Sara; Mignardi, Marco; Imgenberg-Kreuz, Juliana et al.

Part of Oncotarget, p. 2407-2418, 2013

Automated serial extraction of DNA and RNA from biobanked tissue specimens

Mathot, Lucy; Wallin, Monica; Sjöblom, Tobias

Part of BMC Biotechnology, p. 66, 2013

• DOI for Automated serial extraction of DNA and RNA from biobanked tissue specimens
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STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Pena, Cristina; Virtudes Cespedes, Maria; Lindh, Maja Bradic; Kiflemariam, Sara et al.

Part of Cancer Research, p. 1287-1297, 2013

• DOI for STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Validation of a yeast functional assay for p53 mutations using clonal sequencing

Iggo, Richard; Rudewicz, Justine; Monceau, Elodie; Sevenet, Nicolas et al.

Part of Journal of Pathology, p. 441-448, 2013

• DOI for Validation of a yeast functional assay for p53 mutations using clonal sequencing

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Hernlund, Emma; Olofsson, Maria Hägg; Fayad, Walid; Fryknäs, Mårten et al.

Part of European Journal of Cancer, p. 396-406, 2012

• DOI for The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Scalable In Situ Hybridization on Tissue Arrays for Validation of Novel Cancer and Tissue-Specific Biomarkers

Kiflemariam, Sara; Andersson, Sandra; Asplund, Anna; Pontén, Fredrik et al.

Part of PLOS ONE, 2012

• DOI for Scalable In Situ Hybridization on Tissue Arrays for Validation of Novel Cancer and Tissue-Specific Biomarkers
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Automated Genotyping of Biobank Samples by Multiplex Amplification of Insertion/Deletion Polymorphisms

Mathot, Lucy; Falk Sörqvist, Elin; Moens, Lotte; Allen, Marie et al.

Part of PLOS ONE, 2012

• DOI for Automated Genotyping of Biobank Samples by Multiplex Amplification of Insertion/Deletion Polymorphisms
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Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

Jiao, Xiang; Wood, Laura D.; Lindman, Monica; Jones, Sian et al.

Part of Genes, Chromosomes and Cancer, p. 480-489, 2012

• DOI for Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

Direct Detection of TMPRSS2-ERG Rearrangements in Prostate Cancer by Padlock Probes

Kiflemariam, Sara; Mignardi, M.; Bergh, A.; Nilsson, M. et al.

Part of European Journal of Cancer, 2012

• DOI for Direct Detection of TMPRSS2-ERG Rearrangements in Prostate Cancer by Padlock Probes

Core Ras Pathway Signaling in Human Colorectal Cancers Revealed by Isogenic Modeling of NF1, KRAS and BRAF Mutations

Ali, Muhammad Akhtar; Sjöblom, Tobias

Part of European Journal of Cancer, 2012

• DOI for Core Ras Pathway Signaling in Human Colorectal Cancers Revealed by Isogenic Modeling of NF1, KRAS and BRAF Mutations

Targeted resequencing of candidate genes using Selector Probes

Johansson, Henrik; Isaksson, Magnus; Sörqvist, Elin Falk; Roos, F. et al.

Part of Nucleic Acids Research, 2011

• DOI for Targeted resequencing of candidate genes using Selector Probes

Common pathogenetic mechanism involving human chromosome 18 in familial and sporadic ileal carcinoid tumors

Cunningham, Janet L.; Díaz de Ståhl, Teresita; Sjöblom, Tobias; Westin, Gunnar et al.

Part of Genes, Chromosomes and Cancer, p. 82-94, 2011

• DOI for Common pathogenetic mechanism involving human chromosome 18 in familial and sporadic ileal carcinoid tumors

Structural Alterations from Multiple Displacement Amplification of a Human Genome Revealed by Mate-Pair Sequencing

Jiao, Xiang; Rosenlund, Magnus; Hooper, Sean D.; Tellgren-Roth, Christian et al.

Part of PLOS ONE, 2011

• DOI for Structural Alterations from Multiple Displacement Amplification of a Human Genome Revealed by Mate-Pair Sequencing
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Efficient and scalable serial extraction of DNA and RNA from frozen tissue samples

Mathot, Lucy; Lindman, Monica; Sjöblom, Tobias

Part of Chemical Communications, p. 547-549, 2010

• DOI for Efficient and scalable serial extraction of DNA and RNA from frozen tissue samples

Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer

Paulsson, Janna; Sjöblom, Tobias; Micke, Patrick; Pontén, Fredrik et al.

Part of American Journal of Pathology, p. 334-341, 2009

• DOI for Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer

Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

Gal, Annamaria; Sjöblom, Tobias; Fedorova, L.; Imreh, S. et al.

Part of Oncogene, p. 1218-1230, 2008

• DOI for Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method

Jarvius, Malin; Paulsson, Janna; Weibrecht, Irene; Leuchowius, Karl-Johan et al.

Part of Molecular & Cellular Proteomics, p. 1500-1509, 2007

• DOI for In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method

The genomic landscapes of human breast and colorectal cancers.

Wood, Laura D; Parsons, D Williams; Jones, Siân; Lin, Jimmy et al.

Part of Science, p. 1108-1113, 2007

• DOI for The genomic landscapes of human breast and colorectal cancers.

A multidimensional analysis of genes mutated in breast and colorectal cancers

Lin, Jimmy; Gan, Christine M; Zhang, Xiaosong; Jones, Siân et al.

Part of Genome Research, p. 1304-1318, 2007

• DOI for A multidimensional analysis of genes mutated in breast and colorectal cancers

An antibody-based method for monitoring in vivo oxidation of protein tyrosine phosphatases

Persson, Camilla; Kappert, Kai; Engström, Ulla; Östman, Arne et al.

Part of Methods, p. 37-43, 2005

• DOI for An antibody-based method for monitoring in vivo oxidation of protein tyrosine phosphatases

Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

Furuhashi, Masao; Sjöblom, Tobias; Abramsson, Alexandra; Ellingsen, Jens et al.

Part of Cancer Research, p. 2725-2733, 2004

• DOI for Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases

Persson, Camilla; Sjöblom, Tobias; Groen, Arnoud; Kappert, Kai et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 1886-1891, 2004

• DOI for Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases

Smad2 suppresses the growth of Mv1Lu cells subcutaneously inoculated in mice

Sjöblom, Tobias; Yakymovych, Ihor; Heldin, Carl-Henrik; Östman, Arne et al.

Part of European Journal of Cancer, p. 267-274, 2004

• DOI for Smad2 suppresses the growth of Mv1Lu cells subcutaneously inoculated in mice

Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy

Pontén, Annica; Li, Xuri; Thorén, Peter; Aase, Karin et al.

Part of American Journal of Pathology, p. 673-682, 2003

• DOI for Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy

Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit

Gazit, Aviv; Yee, Kevin; Uecker, Andrea; Böhmer, Frank-D. et al.

Part of Bioorganic & Medicinal Chemistry, p. 2007-2018, 2003

• DOI for Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit

Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

Zhang, Xiaonan; Sjöblom, Tobias

Part of Pharmaceuticals, 2021

• DOI for Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy
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Recurrence Risk after Radical Colorectal Cancer Surgery: Less Than before, But How High Is It?

Osterman, Erik; Hammarström, Klara; Imam, Israa; Österlund, Emerik et al.

Part of Cancers, 2020

• DOI for Recurrence Risk after Radical Colorectal Cancer Surgery: Less Than before, But How High Is It?
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Molecular pathways in tumor progression: from discovery to functional understanding

Ali, Muhammad Akhtar; Sjöblom, Tobias

Part of Molecular bioSystems, p. 902-908, 2009

• DOI for Molecular pathways in tumor progression: from discovery to functional understanding

Systematic analyses of the cancer genome: Lessons learned from sequencing most of the annotated human protein-coding genes

Sjöblom, Tobias

Part of Current Opinion in Oncology, p. 66-71, 2008

• DOI for Systematic analyses of the cancer genome: Lessons learned from sequencing most of the annotated human protein-coding genes

Platelet-Derived Growth Factor: Normal Function, Role in Disease, and Application of PDGF Antagonists

Sjöblom, Tobias; Pietras, Kristian; Östman, Arne; Heldin, Carl-Henrik

Part of Protein Tyrosine Kinases, p. 161-186, Humana Press, 2005

• DOI for Platelet-Derived Growth Factor: Normal Function, Role in Disease, and Application of PDGF Antagonists

BM and CEA as Serum Markers in Detecting Colorectal Cancer Recurrence: A Comparative Study

D, J; Osterman, Erik; C, C; G, M et al.

Primary tumor location, molecular alterations, treatment, and outcome in a population-based metastatic colorectal cancer cohort

Osterlund, Emerik; Hammarström, Klara; Nunes, Luís; Mathot, Lucy et al.

Prognostic whole-genome and transcriptome signatures in colorectal cancers

Nunes, Luís; Li, Fuqiang; Wu, Meizhen; Luo, Tian et al.

Enhancer signatures define glioblastoma stem cell subtypes 1 with divergent patient survival

Xing, Pengwei; Neves, Ines; Salehi, Maede; Yadav, Ram Prakash et al.

Interpreting translocations detected by paired-end sequencing of cancer samples

Hooper, Sean D; Jiao, Xiang; Rosenlund, Magnus; Tellgren-Roth, Christian et al.

Segmentation and Measurements of Major Blood Vessels from CT Pulmonary Angiography Using Deep Learning

Kahraman, Ali Teymur; Fröding, Tomas; Toumpanakis, Dimitrios; Gustafsson, Christian Jamtheim et al.

• DOI for Segmentation and Measurements of Major Blood Vessels from CT Pulmonary Angiography Using Deep Learning

Identification of novel target genes for LOH-based cancer therapy

Rameika, Natallia; Veanes, Margus; Akcan, Ece; Kundu, Snehangshu et al.

Novel anti-cancer agents targeting NAT2 loss in colorectal cancer

Rameika, Natallia; Tsiara, Ioanna; Haberek, Wawrzyniec; Akcan, Ece et al.