Anders Tengholm

Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes

Yang, Mingyu; Mandal, Kousik; Södergren, Moa; Dumral, Özge et al.

Part of Acta Physiologica, 2025

• DOI for Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes
• Download full text (pdf) of Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes

Mechanistic insights and approaches for beta cell regeneration

Karampelias, Christos; Liu, Ka-Cheuk; Tengholm, Anders; Andersson, Olov

Part of Nature Chemical Biology, 2025

• DOI for Mechanistic insights and approaches for beta cell regeneration

Bo Hellman, 19 June 1930-4 December 2023

Gylfe, Erik; Tengholm, Anders

Part of Diabetologia, p. 1165-1167, 2024

• DOI for Bo Hellman, 19 June 1930-4 December 2023

OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

Panagiotou, Styliani; Tan, Kia Wee; Nguyen, Phuoc My; Mueller, Andreas et al.

Part of Cell Reports, 2024

• DOI for OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion
• Download full text (pdf) of OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Part of Diabetologia, p. 1642-1662, 2024

• DOI for RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
• Download full text (pdf) of RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes

Yang, Mingyu; Mandal, Kousik; Södergren, Moa; Dumral, Özge et al.

Part of Acta Physiologica, 2025

• DOI for Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes
• Download full text (pdf) of Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes

Mechanistic insights and approaches for beta cell regeneration

Karampelias, Christos; Liu, Ka-Cheuk; Tengholm, Anders; Andersson, Olov

Part of Nature Chemical Biology, 2025

• DOI for Mechanistic insights and approaches for beta cell regeneration

Bo Hellman, 19 June 1930-4 December 2023

Gylfe, Erik; Tengholm, Anders

Part of Diabetologia, p. 1165-1167, 2024

• DOI for Bo Hellman, 19 June 1930-4 December 2023

OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

Panagiotou, Styliani; Tan, Kia Wee; Nguyen, Phuoc My; Mueller, Andreas et al.

Part of Cell Reports, 2024

• DOI for OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion
• Download full text (pdf) of OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Part of Diabetologia, p. 1642-1662, 2024

• DOI for RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
• Download full text (pdf) of RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Insulin release from isolated cat islets of Langerhans

Strage, Emma M.; Ley, Cecilia; Westermark, Gunilla T.; Tengholm, Anders

Part of Domestic Animal Endocrinology, 2024

• DOI for Insulin release from isolated cat islets of Langerhans
• Download full text (pdf) of Insulin release from isolated cat islets of Langerhans

Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells

Yang, Mingyu; Dyachok, Oleg; Xu, Yunjian; Gylfe, Erik et al.

Part of Cellular Signalling, 2023

• DOI for Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells
• Download full text (pdf) of Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Part of Nature Biotechnology, p. 1042-1055, 2022

• DOI for Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
• Download full text (pdf) of Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

Vishnu, N.; Hamilton, A.; Bagge, A.; Wernersson, A. et al.

Part of Molecular Metabolism, 2021

• DOI for Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

Glucose-induced cAMP elevation in β-cells involves amplification of constitutive and glucagon-activated GLP-1 receptor signalling

Shuai, Hongyan; Xu, Yunjian; Ahooghalandari, Parvin; Tengholm, Anders

Part of Acta Physiologica, 2021

• DOI for Glucose-induced cAMP elevation in β-cells involves amplification of constitutive and glucagon-activated GLP-1 receptor signalling
• Download full text (pdf) of Glucose-induced cAMP elevation in β-cells involves amplification of constitutive and glucagon-activated GLP-1 receptor signalling

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Part of Nature Communications, 2020

• DOI for Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
• Download full text (pdf) of Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion

Yu, Qian; Lai, Bao Khanh; Ahooghalandari, Parvin; Helander, Anders et al.

Part of Journal of Biological Chemistry, 2020

• DOI for γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion
• Download full text (pdf) of γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Petrenko, Volodymyr; Gandasi, Nikhil; Sage, Daniel; Tengholm, Anders et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 2484-2495, 2020

• DOI for In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis
• Download full text (pdf) of In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Cyclic AMP links glucose stimulation to somatostatin secretion in delta-cells

Tengholm, Anders

Part of The Journal of General Physiology, p. 1062-1065, 2019

• DOI for Cyclic AMP links glucose stimulation to somatostatin secretion in delta-cells

Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB

Pietilä, Ilkka; van Mourik, Djenolan; Tamelander, Andreas; Kriz, Vitezslav et al.

Part of Cells, 2019

• DOI for Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB
• Download full text (pdf) of Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB

A membrane permeable prodrug of S223 for selective Epac2 activation in living cells

Xu, Yunjian; Schwede, Frank; Wienk, Hans; Tengholm, Anders et al.

Part of Cells, 2019

• DOI for A membrane permeable prodrug of S223 for selective Epac2 activation in living cells
• Download full text (pdf) of A membrane permeable prodrug of S223 for selective Epac2 activation in living cells

Glucose controls glucagon secretion by directly modulating cAMP in alpha cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Part of Diabetologia, p. 1212-1224, 2019

• DOI for Glucose controls glucagon secretion by directly modulating cAMP in alpha cells
• Download full text (pdf) of Glucose controls glucagon secretion by directly modulating cAMP in alpha cells

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Gucek, Alenka; Gandasi, Nikhil R; Omar-Hmeadi, Muhmmad; Bakke, Marit et al.

Part of eLIFE, 2019

• DOI for Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
• Download full text (pdf) of Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Mojtaba Ghiasi, Seyed; Dahlby, Tina; Hede Andersen, Caroline; Haataja, Leena et al.

Part of Diabetes, p. 747-760, 2019

• DOI for The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells

Wang, Xuan; Jiang, Lin; Wallerman, Ola; Younis, Shady et al.

Part of The FASEB Journal, p. 88-100, 2019

• DOI for ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells

Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

Korol, Sergiy V; Jin, Zhe; Jin, Yang; Bhandage, Amol K. et al.

Part of EBioMedicine, 2018

• DOI for Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells
• Download full text (pdf) of Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

A genetically encoded low-affinity Ca2+ sensor unmasks autocrine purinergic signalling in beta cells

Yang, Mingyu; Idevall-Hagren, Olof; Gylfe, Erik; Tengholm, Anders

Part of Diabetologia, 2018

Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Alenkvist, Ida; Gandasi, Nikhil R; Barg, Sebastian; Tengholm, Anders

Part of Diabetes, p. 2610-2622, 2017

• DOI for Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging

Shuai, Hongyan; Xu, Yunjian; Yu, Qian; Gylfe, Erik et al.

Part of Pflügers Archiv, p. 1765-1777, 2016

• DOI for Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging
• Download full text (pdf) of Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging

Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

Tuomi, Tiinamaija; Nagorny, Cecilia L. F.; Singh, Pratibha; Bennet, Hedvig et al.

Part of Cell Metabolism, p. 1067-1077, 2016

• DOI for Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

Autocrine Signaling Underlies Fast Repetitive Plasma Membrane Translocation of Conventional and Novel Protein Kinase C Isoforms in beta Cells

Wuttke, Anne; Yu, Qian; Tengholm, Anders

Part of Journal of Biological Chemistry, p. 14986-14995, 2016

• DOI for Autocrine Signaling Underlies Fast Repetitive Plasma Membrane Translocation of Conventional and Novel Protein Kinase C Isoforms in beta Cells
• Download full text (pdf) of Autocrine Signaling Underlies Fast Repetitive Plasma Membrane Translocation of Conventional and Novel Protein Kinase C Isoforms in beta Cells

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion

Abels, Mia; Riva, Matteo; Bennet, Hedvig; Ahlqvist, Emma et al.

Part of Diabetologia, p. 1928-1937, 2016

• DOI for CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion

Glucose lowers cAMP to inhibit glucagon secretion by a direct effect on alpha cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Part of Diabetologia, 2016

ZBED6 negatively regulates insulin content, glucose-stimulated insulin secretion, neuronal differentiation and cell aggregation in MIN6 cells

Wang, Xuan; Jiang, L.; Wallerman, Ola; Yu, Qian et al.

Part of Diabetologia, 2016

Neuropeptide S inhibits gastrointestinal motility and increases mucosal permeability through nitric oxide

Wan Saudi, Wan Salman; Halim, Mohammed Abdul; Gillberg, Linda; Rudholm-Feldreich, Tobias et al.

Part of American Journal of Physiology - Gastrointestinal and Liver Physiology, 2015

• DOI for Neuropeptide S inhibits gastrointestinal motility and increases mucosal permeability through nitric oxide

Prolonged exposure to palmitate deteriorates glucose-induced cAMP generation and pulsatile insulin secretion

Tian, Geng; Tengholm, Anders

Part of Diabetes/Metabolism Research Reviews, p. 9-10, 2015

Submembrane ATP and Ca²⁺ kinetics in α‑cells: unexpected signaling for glucagon secretion

Li, Jia; Yu, Qian; Ahooghalandari, Parvin; Gribble, Fiona M et al.

Part of The FASEB Journal, p. 3379-3388, 2015

• DOI for Submembrane ATP and Ca²⁺ kinetics in α‑cells: unexpected signaling for glucagon secretion

Submembrane ATP and Ca2+ kinetics in alpha-cells: unexpected signaling for glucagon secretion

Li, Jia; Yu, Qian; Ahooghalandari, Parvin; Gribble, Fiona M. et al.

Part of The FASEB Journal, p. 3379-3388, 2015

• DOI for Submembrane ATP and Ca2+ kinetics in alpha-cells: unexpected signaling for glucagon secretion

Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate

Tian, Geng; Sol, Eri Maria; Xu, Yunjian; Shuai, Hongyan et al.

Part of Diabetes, p. 904-915, 2015

• DOI for Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate
• Download full text (pdf) of Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate

Paradoxical Ca2+ kinetics in islet-located glucagon-releasing alpha cells

Yu, Qian; Li, Jia; Ahooghalandari, Parvin; Tengholm, Anders et al.

Part of Diabetologia, 2015

CART is a novel glucose-dependent peptide with antidiabetic actions in humans

Abels, M.; Riva, M.; Poon, W.; Bennet, H. et al.

Part of Diabetologia, 2015

Purinergic P2Y1 receptors take centre stage in autocrine stimulation of human beta cells

Tengholm, Anders

Part of Diabetologia, p. 2436-2439, 2014

• DOI for Purinergic P2Y1 receptors take centre stage in autocrine stimulation of human beta cells
• Download full text (pdf) of Purinergic P2Y1 receptors take centre stage in autocrine stimulation of human beta cells

Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets

Alenkvist, Ida; Dyachok, Oleg; Tian, Geng; Li, Jia et al.

Part of Journal of Endocrinology, p. 267-275, 2014

• DOI for Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets
• Download full text (pdf) of Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets

Paradoxical synchronisation of Ca2+ oscillations between alpha and beta cells within intact pancreatic islets

Yu, Qian; Li, Jia; Tengholm, Anders; Gylfe, Erik

Part of Diabetologia, 2014

P2Y₁ receptor-dependent diacylglycerol signaling microdomains in β cells promote insulin secretion

Wuttke, Anne; Idevall-Hagren, Olof; Tengholm, Anders

Part of The FASEB Journal, p. 1610-1620, 2013

• DOI for P2Y₁ receptor-dependent diacylglycerol signaling microdomains in β cells promote insulin secretion

Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic beta Cells

Idevall-Hagren, Olof; Jakobsson, Ida; Xu, Yunjian; Tengholm, Anders

Part of Science Signaling, 2013

• DOI for Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic beta Cells

Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl

Mokhtari, Dariush; Al-Amin, Abdullah; Turpaev, Kyrill; Li, Tingting et al.

Part of Diabetologia, p. 1327-1338, 2013

• DOI for Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl
• Download full text (pdf) of Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl

The role of mechanical force and ROS in integrin-dependent signals

Zeller, Kathrin Stephanie; Riaz, Anjum; Sarve, Hamid; Li, Jia et al.

Part of PLOS ONE, 2013

• DOI for The role of mechanical force and ROS in integrin-dependent signals
• Download full text (pdf) of The role of mechanical force and ROS in integrin-dependent signals

DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms

Hoivik, Erling A.; Witsoe, Solveig L.; Bergheim, Inger R.; Xu, Yunjian et al.

Part of PLOS ONE, 2013

• DOI for DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms
• Download full text (pdf) of DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms

Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

Zang, Guangxiang; Christoffersson, Gustaf; Tian, Geng; Harun-Or-Rashid, Mohammad et al.

Part of Cellular Signalling, p. 85-92, 2013

• DOI for Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells
• Download full text (pdf) of Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

Autocrine signals mediate plasma membrane translocation of protein kinase C in insulin-secreting cells

Tengholm, Anders; Wuttke, Anne

Part of Diabetologia, 2013

Functional differences between aggregated and dispersed insulin-producing cells

Chowdhury, Azazul Islam; Dyachok, Oleg; Tengholm, Anders; Sandler, Stellan et al.

Part of Diabetologia, p. 1557-1568, 2013

• DOI for Functional differences between aggregated and dispersed insulin-producing cells
• Download full text (pdf) of Functional differences between aggregated and dispersed insulin-producing cells

Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+

Li, Jia; Shuai, Hongyan; Gylfe, Erik; Tengholm, Anders

Part of Diabetologia, p. 1577-1586, 2013

• DOI for Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+
• Download full text (pdf) of Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+

Prolonged exposure to palmitate deteriorates glucose-induced cAMP generation and pulsatile insulin secretion

Tian, Geng; Sol, E. -RM.; Xu, Yunjian; Tengholm, Anders

Part of Diabetologia, 2013

cAMP Induces Stromal Interaction Molecule 1 (STIM1) Puncta but neither Orai1 Protein Clustering nor Store-operated Ca2+ Entry (SOCE) in Islet Cells

Tian, Geng; Tepikin, Alexei V.; Tengholm, Anders; Gylfe, Erik

Part of Journal of Biological Chemistry, p. 9862-9872, 2012

• DOI for cAMP Induces Stromal Interaction Molecule 1 (STIM1) Puncta but neither Orai1 Protein Clustering nor Store-operated Ca2+ Entry (SOCE) in Islet Cells
• Download full text (pdf) of cAMP Induces Stromal Interaction Molecule 1 (STIM1) Puncta but neither Orai1 Protein Clustering nor Store-operated Ca2+ Entry (SOCE) in Islet Cells

Anchored phosphatases modulate glucose homeostasis

Hinke, Simon A.; Navedo, Manuel F.; Ulman, Allison; Whiting, Jennifer L. et al.

Part of EMBO Journal, p. 3991-4004, 2012

• DOI for Anchored phosphatases modulate glucose homeostasis

Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion

Tian, Geng; Sågetorp, Jenny; Xu, Yunjian; Shuai, Hongyan et al.

Part of Journal of Cell Science, p. 5084-5095, 2012

• DOI for Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion

Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets

Tian, Geng; Sandler, Stellan; Gylfe, Erik; Tengholm, Anders

Part of Diabetes, p. 1535-1543, 2011

• DOI for Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets

Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet beta-Cells

Dezaki, Katsuya; Damdindorj, Boldbaatar; Sone, Hideyuki; Dyachok, Oleg et al.

Part of Diabetes, p. 2315-2324, 2011

• DOI for Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet beta-Cells

PI3-kinase p110 alpha mediates beta 1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading

Zeller, Kathrin S.; Idevall Hagren, Olof; Stefansson, Anne; Velling, Teet et al.

Part of Cellular Signalling, p. 1838-1848, 2010

• DOI for PI3-kinase p110 alpha mediates beta 1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading

Ca2+ and cAMP Signaling in Human Embryonic Stem Cell-Derived Dopamine Neurons

Malmersjö, Seth; Liste, Isabel; Dyachok, Oleg; Tengholm, Anders et al.

Part of Stem Cells and Development, p. 1355-1364, 2010

• DOI for Ca2+ and cAMP Signaling in Human Embryonic Stem Cell-Derived Dopamine Neurons

Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane

Hafizi, Sassan; Gustafsson, Anna; Oslakovic, Cecilia; Idevall-Hagren, Olof et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 396-401, 2010

• DOI for Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane

Glucose induces oscillations of the ATP/ADP ratio in individual beta cells

Li, Jia; Gylfe, Erik; Tengholm, Anders

Part of Diabetologia, 2010

Glucose regulation of STIM1 translocation reflecting store-operated channel modulation in pancreatic islet cells

Tian, Geng; Tepikin, A. V.; Tengholm, Anders; Gylfe, Erik

Part of Diabetologia, 2010

Crosstalk between cAMP- and Zn2+-signalling in insulin secretion

Dyachok, Oleg; Idevall, Olof; Tengholm, Anders; Gylfe, Erik

Part of Diabetologia, 2010

Spatial control of Epac2 by cAMP and Ca2+

Idevall, Olof; Tengholm, Anders

Part of Diabetologia, 2010

cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Idevall Hagren, Olof; Barg, Sebastian; Gylfe, Erik; Tengholm, Anders

Part of Journal of Biological Chemistry, p. 23005-23016, 2010

• DOI for cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Ultraviolet becomes accessible

Illy, Elizabeth; Tengholm, Anders

Part of BioOptics World, p. 22-26, 2010

Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P₂ dynamics in secretagogue-stimulated β-cells

Wuttke, Anne; Sågetorp, Jenny; Tengholm, Anders

Part of Journal of Cell Science, p. 1492-1502, 2010

• DOI for Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P₂ dynamics in secretagogue-stimulated β-cells

Wnt-5a-induced Phosphorylation of DARPP-32 Inhibits Breast Cancer Cell Migration in a CREB-dependent Manner

Hansen, Christian; Howlin, Jillian; Tengholm, Anders; Dyachok, Oleg et al.

Part of Journal of Biological Chemistry, p. 27533-27543, 2009

• DOI for Wnt-5a-induced Phosphorylation of DARPP-32 Inhibits Breast Cancer Cell Migration in a CREB-dependent Manner

Capacitative Ca2+ Entry via Orai1 and Stromal Interacting Molecule 1 (STIM1) Regulates Adenylyl Cyclase Type 8

Martin, Agnes C. L.; Willoughby, Debbie; Ciruela, Antonio; Ayling, Laura-Jo et al.

Part of Molecular Pharmacology, p. 830-842, 2009

• DOI for Capacitative Ca2+ Entry via Orai1 and Stromal Interacting Molecule 1 (STIM1) Regulates Adenylyl Cyclase Type 8

Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion

Dyachok, Oleg; Idevall-Hagren, Olof; Sågetorp, Jenny; Tian, Geng et al.

Part of Cell Metabolism, p. 26-37, 2008

• DOI for Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion
• Download full text (pdf) of Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion

Cyclic AMP: swing that message!

Tengholm, Anders

Part of Cellular and Molecular Life Sciences (CMLS), p. 382-385, 2007

• DOI for Cyclic AMP: swing that message!

Rapid turnover of phosphatidylinositol-4,5-bisphosphate in insulin-secreting cells mediated by Ca2+ and the ATP-to-ADP ratio

Thore, Sophia; Wuttke, Anne; Tengholm, Anders

Part of Diabetes, p. 818-826, 2007

• DOI for Rapid turnover of phosphatidylinositol-4,5-bisphosphate in insulin-secreting cells mediated by Ca2+ and the ATP-to-ADP ratio

Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion

Zhang, Fan; Zhang, Qimin; Tengholm, Anders; Sjöholm, Åke

Part of American Journal of Physiology - Cell Physiology, 2006

• DOI for Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion

Glucose and insulin synergistically activate phosphatidylinositol 3-kinase to trigger oscillations of phosphatidylinositol 3,4,5-trisphosphate in beta-cells

Idevall Hagren, Olof; Tengholm, Anders

Part of Journal of Biological Chemistry, p. 39121-39127, 2006

• DOI for Glucose and insulin synergistically activate phosphatidylinositol 3-kinase to trigger oscillations of phosphatidylinositol 3,4,5-trisphosphate in beta-cells

cAMP oscillations restrict protein kinase A redistribution in insulin-secreting cells.

Dyachok, O; Sagetorp, J; Isakov, Y; Tengholm, A

Part of Biochem Soc Trans, p. 498-501, 2006

Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells.

Dyachok, Oleg; Isakov, Yegor; Sågetorp, Jenny; Tengholm, Anders

Part of Nature, p. 349-52, 2006

Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca²⁺ in insulin-secreting β-cells

Thore, Sophia; Dyachok, Oleg; Gylfe, Erik; Tengholm, Anders

Part of Journal of Cell Science, p. 4463-4471, 2005

• DOI for Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca²⁺ in insulin-secreting β-cells
• Download full text (pdf) of Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca²⁺ in insulin-secreting β-cells

siRNA Produced by Recombinant Dicer Mediates Efficient Gene Silencing in Islet Cells.

Hägerkvist, Robert; Mokhtari, Dariush; Myers, Jason W; Tengholm, Anders et al.

Part of Ann N Y Acad Sci, p. 114-22, 2005

Oscillations of Phospholipase C Activity Triggered by Depolarizatio and Ca2+ Influx in Insulin-secreting Cells

Thore, Sophia; Dyachok, Oleg; Tengholm, Anders

Part of The Journal of Biological Chemistry (JBC), p. 19396-19400, 2004

Glucose controls glucagon secretion by directly modulating cAMP in α‑cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Metabolic regulation of calcium signaling in beta cells

Idevall Hagren, Olof; Tengholm, Anders

Part of Seminars in Cell and Developmental Biology, p. 20-30, 2020

• DOI for Metabolic regulation of calcium signaling in beta cells

cAMP signalling in insulin and glucagon secretion

Tengholm, Anders; Gylfe, Erik

Part of Diabetes, obesity and metabolism, p. 42-53, 2017

• DOI for cAMP signalling in insulin and glucagon secretion

Neurotransmitter control of islet hormone pulsatility

Gylfe, Erik; Tengholm, Anders

Part of Diabetes, obesity and metabolism, p. 102-110, 2014

• DOI for Neurotransmitter control of islet hormone pulsatility

Cyclic AMP dynamics in the pancreatic beta-cell

Tengholm, Anders

Part of Upsala Journal of Medical Sciences, p. 355-369, 2012

• DOI for Cyclic AMP dynamics in the pancreatic beta-cell

Oscillatory control of insulin secretion

Tengholm, Anders; Gylfe, Erik

Part of Molecular and Cellular Endocrinology, p. 58-72, 2009

• DOI for Oscillatory control of insulin secretion
• Download full text (pdf) of Oscillatory control of insulin secretion

Spatio-Temporal Dynamics of Phosphatidylinositol-3,4,5-Trisphosphate Signalling

Tengholm, Anders; Idevall-Hagren, Olof

Part of Vitamines and Hormones, p. 287-311, 2009

• DOI for Spatio-Temporal Dynamics of Phosphatidylinositol-3,4,5-Trisphosphate Signalling

Fluorescent Translocation Reporters for Sub–plasma Membrane cAMP Imaging

Dyachok, Oleg; Xu, Yunjian; Idevall, Olof; Tengholm, Anders

Part of cAMP Signaling, p. 319-338, Humana Press, 2022

• DOI for Fluorescent Translocation Reporters for Sub–plasma Membrane cAMP Imaging

Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters

Tengholm, Anders; Idevall-Hagren, Olof

Part of cAMP Signaling, p. 85-101, Springer-Verlag New York, 2015

• DOI for Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters
• Download full text (pdf) of Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters

Imaging phosphoinositide dynamics in living cells

Wuttke, Anne; Idevall-Hagren, Olof; Tengholm, Anders

Part of Inositol Phosphates and Lipids, p. 219-235, Humana Press, 2010

• DOI for Imaging phosphoinositide dynamics in living cells
• Download full text (pdf) of Imaging phosphoinositide dynamics in living cells

Exocytotic release of ATP triggers diacylglycerol spiking in insulin-secreting cells

Wuttke, Anne; Idevall-Hagren, Olof; Tengholm, Anders

Part of Minutes Of The 46th General Assembly Of The European Association For The Study Of Diabetes, 2011

• DOI for Exocytotic release of ATP triggers diacylglycerol spiking in insulin-secreting cells

Glucose and muscarinic stimulation trigger distinct diacylglycerol signals in pancreatic beta cells

Wuttke, Anne; Emanuelsson, H.; Tengholm, Anders

2010

Secretagogue-induced elevation of the plasma membrane PtdIns4P concentration in individual insulin-secreting cells

Wuttke, Anne; Tengholm, Anders

Part of 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, SEP 30-OCT 02, 2009, 2009

In situ characterisation of plasma membrane PtdIns(4)P and PtdIns(4,5)P 2 turnover in individual insulin secreting cells

Wuttke, Anne; Tengholm, Anders

2008

Type III phosphatidylinositol 4-kinases mediate plasma membrane PIP2 synthesis in insulin-secreting cells

Wuttke, Anne; Sagetorp, J.; Welsh, Nils; Tengholm, Anders

Part of 43rd easd annual meeting of the european association for the study of diabetes, 2007

• DOI for Type III phosphatidylinositol 4-kinases mediate plasma membrane PIP2 synthesis in insulin-secreting cells

Quantitative assessment of glucose-regulated cAMP signalling and protein kinase A-mediated glucagon secretion.

Yu, Qian; Gylfe, Erik; Tengholm, Anders

Effects of Ca²⁺ and autocrine signals on cAMP dynamics in β-cells

Shuai, Hongyan; Tengholm, Anders

Glucagon and GLP-1 evoke cAMP elevations in sub-populations of mouse and human α-cells

Shuai, Hongyan; Tengholm, Anders

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.