Ulf Landegren
- Mobile phone:
- +46 70 896 26 04
- E-mail:
- ulf.landegren@igp.uu.se
- Visiting address:
- BMC, Husargatan 3
751 22 Uppsala - Postal address:
- Box 815
751 08 Uppsala
Publications
Recent publications
Part of Scientific Reports, 2024
- DOI for Monitoring SARS-CoV-2 IgA, IgM and IgG antibodies in dried blood and saliva samples using antibody proximity extension assays (AbPEA)
- Download full text (pdf) of Monitoring SARS-CoV-2 IgA, IgM and IgG antibodies in dried blood and saliva samples using antibody proximity extension assays (AbPEA)
Part of Cancers, 2024
- DOI for Sensitive and Specific Analyses of Colorectal Cancer Recurrence through Multiplex superRCA Mutation Detection in Blood Plasma
- Download full text (pdf) of Sensitive and Specific Analyses of Colorectal Cancer Recurrence through Multiplex superRCA Mutation Detection in Blood Plasma
Managing leukemia patients via liquid biopsy and super rolling circle amplification (superRCA)
Part of Journal of Internal Medicine, p. 228-237, 2023
Part of New Biotechnology, p. 139-148, 2022
- DOI for Detection of SARS-CoV-2 antibodies in serum and dried blood spot samples of vaccinated individuals using a sensitive homogeneous proximity extension assay
- Download full text (pdf) of Detection of SARS-CoV-2 antibodies in serum and dried blood spot samples of vaccinated individuals using a sensitive homogeneous proximity extension assay
Part of Communications Biology, 2022
- DOI for Surface protein profiling of prostate-derived extracellular vesicles by mass spectrometry and proximity assays
- Download full text (pdf) of Surface protein profiling of prostate-derived extracellular vesicles by mass spectrometry and proximity assays
All publications
Articles in journal
Part of Scientific Reports, 2024
- DOI for Monitoring SARS-CoV-2 IgA, IgM and IgG antibodies in dried blood and saliva samples using antibody proximity extension assays (AbPEA)
- Download full text (pdf) of Monitoring SARS-CoV-2 IgA, IgM and IgG antibodies in dried blood and saliva samples using antibody proximity extension assays (AbPEA)
Part of Cancers, 2024
- DOI for Sensitive and Specific Analyses of Colorectal Cancer Recurrence through Multiplex superRCA Mutation Detection in Blood Plasma
- Download full text (pdf) of Sensitive and Specific Analyses of Colorectal Cancer Recurrence through Multiplex superRCA Mutation Detection in Blood Plasma
Managing leukemia patients via liquid biopsy and super rolling circle amplification (superRCA)
Part of Journal of Internal Medicine, p. 228-237, 2023
Part of New Biotechnology, p. 139-148, 2022
- DOI for Detection of SARS-CoV-2 antibodies in serum and dried blood spot samples of vaccinated individuals using a sensitive homogeneous proximity extension assay
- Download full text (pdf) of Detection of SARS-CoV-2 antibodies in serum and dried blood spot samples of vaccinated individuals using a sensitive homogeneous proximity extension assay
Part of Communications Biology, 2022
- DOI for Surface protein profiling of prostate-derived extracellular vesicles by mass spectrometry and proximity assays
- Download full text (pdf) of Surface protein profiling of prostate-derived extracellular vesicles by mass spectrometry and proximity assays
Part of Nucleic Acids Research, 2022
- DOI for Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
- Download full text (pdf) of Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents
Part of Analytical Chemistry, p. 10054-10061, 2022
- DOI for Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents
- Download full text (pdf) of Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobody reagents
Part of Analytical Chemistry, p. 10999-11009, 2021
- DOI for Sensitive Measurement of Drug-Target Engagement by a Cellular Thermal Shift Assay with Multiplex Proximity Extension Readout
- Download full text (pdf) of Sensitive Measurement of Drug-Target Engagement by a Cellular Thermal Shift Assay with Multiplex Proximity Extension Readout
Image-based high-throughput mapping of TGF-beta-induced phosphocomplexes at a single-cell level
Part of Communications Biology, 2021
- DOI for Image-based high-throughput mapping of TGF-beta-induced phosphocomplexes at a single-cell level
- Download full text (pdf) of Image-based high-throughput mapping of TGF-beta-induced phosphocomplexes at a single-cell level
Part of Biochemical and Biophysical Research Communications - BBRC, p. 714-719, 2020
- DOI for Human proteins incorporated into tick-borne encephalitis virus revealed by in situ proximity ligation
- Download full text (pdf) of Human proteins incorporated into tick-borne encephalitis virus revealed by in situ proximity ligation
A multiplex platform for digital measurement of circular DNA reaction products
Part of Nucleic Acids Research, 2020
Proximity Ligation Assay as a Tool for Antibody Validation in Human Tissues
Part of Journal of Histochemistry and Cytochemistry, p. 515-529, 2020
A compendium on single-cell analysis for the curious
Part of The FEBS Journal, p. 1442-1444, 2019
Profiling surface proteins on individual exosomes using a proximity barcoding assay
Part of Nature Communications, 2019
- DOI for Profiling surface proteins on individual exosomes using a proximity barcoding assay
- Download full text (pdf) of Profiling surface proteins on individual exosomes using a proximity barcoding assay
Part of Molecular Oncology, p. 376-391, 2019
- DOI for Protein profiling of fine-needle aspirates reveals subtype-associated immune signatures and involvement of chemokines in breast cancer
- Download full text (pdf) of Protein profiling of fine-needle aspirates reveals subtype-associated immune signatures and involvement of chemokines in breast cancer
Next wave advances in single-cell analyses
Part of The Analyst, p. 735-737, 2019
Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes
Part of Scientific Reports, 2018
- DOI for Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes
- Download full text (pdf) of Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes
Part of Journal of Cardiovascular Translational Research, p. 503-516, 2018
Part of Clinical Chemistry and Laboratory Medicine, p. 582-594, 2018
A fine-needle aspiration-based protein signature discriminates benign from malignant breast lesions
Part of Molecular Oncology, p. 1415-1428, 2018
- DOI for A fine-needle aspiration-based protein signature discriminates benign from malignant breast lesions
- Download full text (pdf) of A fine-needle aspiration-based protein signature discriminates benign from malignant breast lesions
Part of Modern Pathology, p. 253-263, 2018
Part of Nature Communications, 2017
- DOI for Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
- Download full text (pdf) of Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
Part of Scientific Reports, 2017
- DOI for Highly sensitive and specific protein detection via combined capillary isoelectric focusing and proximity ligation
- Download full text (pdf) of Highly sensitive and specific protein detection via combined capillary isoelectric focusing and proximity ligation
Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia
Part of Scientific Reports, p. 1-9, 2017
- DOI for Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia
- Download full text (pdf) of Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia
Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays.
Part of Molecular & Cellular Proteomics, 2017
Stability of Proteins in Dried Blood Spot Biobanks.
Part of Molecular & Cellular Proteomics, p. 1286-1296, 2017
- DOI for Stability of Proteins in Dried Blood Spot Biobanks.
- Download full text (pdf) of Stability of Proteins in Dried Blood Spot Biobanks.
Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assay
Part of Molecular & Cellular Proteomics, p. 502-511, 2017
Part of Clinical Chemistry, p. 1497-1505, 2017
Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
Part of Genome Biology, 2016
- DOI for Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
- Download full text (pdf) of Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells
Part of Cell Reports, p. 380-389, 2016
- DOI for Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells
- Download full text (pdf) of Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells
Part of Scientific Reports, 2016
- DOI for Detecting individual extracellular vesicles using a multicolor in situ proximity ligation assay with flow cytometric readout
- Download full text (pdf) of Detecting individual extracellular vesicles using a multicolor in situ proximity ligation assay with flow cytometric readout
Part of PLOS ONE, 2016
- DOI for Elevated Levels of SOX10 in Serum from Vitiligo and Melanoma Patients, Analyzed by Proximity Ligation Assay
- Download full text (pdf) of Elevated Levels of SOX10 in Serum from Vitiligo and Melanoma Patients, Analyzed by Proximity Ligation Assay
Part of Molecular & Cellular Proteomics, p. 1848-1856, 2016
Part of Translational Oncology, p. 251-255, 2016
- DOI for Detection of prognostic biomarkers with solid-phase proximity ligation assay in patients with colorectal cancer
- Download full text (pdf) of Detection of prognostic biomarkers with solid-phase proximity ligation assay in patients with colorectal cancer
Part of PLOS ONE, 2016
- DOI for A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients
- Download full text (pdf) of A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients
AFFINOMICS and the prospects for large-scale protein analyses
Part of New Biotechnology, p. 491-493, 2016
Part of Haematologica, p. 457-458, 2016
Part of Haematologica, p. 668-669, 2016
Part of British journal of virology, p. 11-23, 2016
Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome
Part of Scientific Reports, 2015
- DOI for Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome
- Download full text (pdf) of Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome
Part of European Journal of Human Genetics, p. 893-900, 2015
Part of Nucleic Acids Research, 2015
Part of Cellular Signalling, p. 1129-1140, 2015
- DOI for CK1 delta restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1 alpha/ARNT complex formation
- Download full text (pdf) of CK1 delta restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1 alpha/ARNT complex formation
FLOW CYTOMETRY-BASED ASSAY FOR DETECTION OF BCR-ABL FUSION PROTEIN IN BLOOD CELLS FROM CML PATIENTS
Part of Haematologica, p. 694-695, 2015
Parallel protein detection by solid-phase proximity ligation assay with real-time PCR or sequencing
Part of Current Protocol in Molecular Biology, 2015
Öppenheten förstör chansen till patent
Part of Svenska dagbladet, 2015
Part of PLOS ONE, 2014
- DOI for Sensitivity and Specificity of In situ Proximity Ligation for Protein Interaction Analysis in a Model of Steatohepatitis with Mallory-Denk Bodies
- Download full text (pdf) of Sensitivity and Specificity of In situ Proximity Ligation for Protein Interaction Analysis in a Model of Steatohepatitis with Mallory-Denk Bodies
A Universal Approach to Prepare Reagents for DNA-Assisted Protein Analysis
Part of PLOS ONE, 2014
- DOI for A Universal Approach to Prepare Reagents for DNA-Assisted Protein Analysis
- Download full text (pdf) of A Universal Approach to Prepare Reagents for DNA-Assisted Protein Analysis
Sensitive detection of aggregated prion protein via proximity ligation
Part of Prion, p. 261-265, 2014
Role of Individual MARK Isoforms in Phosphorylation of Tau at Ser262 in Alzheimer's Disease
Part of Neuromolecular medicine, p. 458-469, 2013
Parallel Visualization of Multiple Protein Complexes in Individual Cells in Tumor Tissue
Part of Molecular & Cellular Proteomics, p. 1563-1571, 2013
Improving Precision of Proximity Ligation Assay by Amplified Single Molecule Detection
Part of PLOS ONE, 2013
- DOI for Improving Precision of Proximity Ligation Assay by Amplified Single Molecule Detection
- Download full text (pdf) of Improving Precision of Proximity Ligation Assay by Amplified Single Molecule Detection
Part of Oncogene, p. 3606-3615, 2013
Workshop on laboratory protocol standards for the molecular methods database
Part of New Biotechnology, p. 109-113, 2013
Elevated MARK2-Dependent Phosphorylation of Tau in Alzheimer's Disease
Part of Journal of Alzheimer's Disease, p. 699-713, 2013
Part of New Biotechnology, p. 144-152, 2013
Part of Nature Protocols, p. 1234-1248, 2013
- DOI for Solid-phase proximity ligation assays for individual or parallel protein analyses with readout via real-time PCR or sequencing
- Download full text (pdf) of Solid-phase proximity ligation assays for individual or parallel protein analyses with readout via real-time PCR or sequencing
Multiplex protein detection with DNA readout via mass spectrometry
Part of New Biotechnology, p. 153-158, 2013
Part of Neuroendocrinology, p. 16-30, 2013
Offshoots of the ESF functional genomics programme
Part of New Biotechnology, p. 296-298, 2013
Profiling cellular protein complexes by proximity ligation with dual tag microarray readout
Part of PLOS ONE, 2012
- DOI for Profiling cellular protein complexes by proximity ligation with dual tag microarray readout
- Download full text (pdf) of Profiling cellular protein complexes by proximity ligation with dual tag microarray readout
Visualising individual sequence-specific protein-DNA interactions in situ
Part of New Biotechnology, p. 589-598, 2012
Opportunities for sensitive plasma proteome analysis
Part of Analytical Chemistry, p. 1824-1830, 2012
Molecular tools for sensitive detection of microvesicles as biomarkers
Part of Protein Science, p. 164-164, 2012
Part of Molecular & Cellular Proteomics, 2012
PCR-Based Multiparametric Assays in Single Cells.
Part of Clinical Chemistry, p. 1618-1619, 2012
Comprehensive catalog of European biobanks
Part of Nature Biotechnology, p. 795-797, 2011
ProteinSeq: high-performance proteomic analyses by proximity ligation and next generation sequencing
Part of PLOS ONE, 2011
Increasing the dynamic range of in situ PLA
Part of Nature Methods, p. 892-893, 2011
Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 8809-8814, 2011
Contributions of the EMERALD project to assessing and improving microarray data quality
Part of BioTechniques, p. 27-31, 2011
Western Blotting via Proximity Ligation for High Performance Protein Analysis
Part of Molecular & Cellular Proteomics, 2011
Part of Clinical Chemistry, p. 99-110, 2010
Sensitive detection of A beta protofibrils by proximity ligation: relevance for Alzheimer's disease
Part of BMC Neuroscience, p. 124, 2010
Part of Molecular & Cellular Proteomics, p. 178-183, 2010
A Community Standard Format for the Representation of Protein Affinity Reagents
Part of Molecular & Cellular Proteomics, p. 1-10, 2010
Part of Journal of Virological Methods, p. 116-122, 2010
Sensitive plasma protein analysis by microparticle-based proximity ligation assays
Part of Molecular & Cellular Proteomics, p. 327-335, 2010
Single molecule analysis of combinatorial splicing
Part of Nucleic Acids Research, 2010
Part of Glycobiology, p. 199-206, 2010
Glycosylases and AP-cleaving enzymes as a general tool for probe-directed cleavage of ssDNA targets
Part of Nucleic Acids Research, 2010
Part of Cytometry: Part A, p. 833-839, 2009
Part of Journal of Microbiological Methods, p. 195-202, 2009
Part of Human Molecular Genetics, p. 2802-2812, 2009
Selective amplification of mutant DNA: mutations come to light in melting DNA
Part of Human Mutation, 2009
Part of Clinical Chemistry, p. 1665-1671, 2009
Estrogen receptor alpha gene polymorphism and endometrial cancer risk: a case-control study
Part of BMC Cancer, p. 322, 2008
Part of Journal of Medical Genetics, p. 362-369, 2008
Part of Methods, p. 227-32, 2008
Part of Briefings in Bioinformatics, p. 14-24, 2008
Part of Clinical Chemistry, p. 1218-1225, 2008
A dual-tag microarray platform for high-performance nucleic acid and protein analyses
Part of Nucleic Acids Research, 2008
Novel and highly recurrent chromosomal alterations in Sézary syndrome
Part of Cancer Research, p. 2689-2698, 2008
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 2427-2432, 2008
Part of Veterinary Microbiology, p. 227-236, 2008
Part of Journal of Clinical Microbiology, p. 1747-1751, 2008
Ligation-based molecular tools for lab-on-a-chip devices
Part of New Biotechnology, p. 42-8, 2008
Self-assembly of proximity probes for flexible and modular proximity ligation assays
Part of BioTechniques, p. 443-450, 2007
Part of Nature Methods, p. 13-17, 2007
Part of Genes & Development, p. 316-331, 2007
Evaluation of beta globin mRNA as an early marker of haemoglobin response to epoetin treatment
Part of Medical Oncology, p. 318-322, 2007
In vitro analysis of DNA-protein interactions by proximity ligation
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 3067-3072, 2007
Sensitive protein detection via triple-binder proximity ligation assays
Part of Nature Methods, p. 135-137, 2007
Part of Molecular & Cellular Proteomics, p. 1500-1509, 2007
Part of Journal of Virological Methods, p. 200-206, 2007
Detection of individual microbial pathogens by proximity ligation
Part of Clinical Chemistry, p. 1152-1160, 2006
DNA Skyline: fonts to facilitate visual inspection of nucleic acid sequences
Part of BioTechniques, p. 740, 2006
Direct observation of individual endogenous protein complexes in situ by proximity ligation
Part of Nature Methods, p. 995-1000, 2006
Molecular markers for discrimination of benign and malignant follicular thyroid tumors
Part of Tumor Biology, p. 211-220, 2006
[Molecular medicine tools. Future prospects with new techniques]
Part of Lakartidningen, p. 2947-52, 2006
A sensitive proximity ligation assay for active PSA.
Part of Biol Chem, p. 769-72, 2006
ProbeMaker: an extensible framework for design of sets of oligonucleotide probes
Part of BMC Bioinformatics, p. 229, 2005
PieceMaker: selection of DNA fragments for selector-guided multiplex amplification
Part of Nucleic Acids Research, 2005
Thermoplastic microfluidic platform for single-molecule detection, cell culture and actuation
Part of Analytical Chemistry, p. 7122-30, 2005
Part of Clin Chem, p. 768-75, 2005
Oestrogen receptor alpha gene haplotype and postmenopausal breast cancer risk: a case control study
Part of Breast Cancer Research, 2004
Part of Journal of Molecular Recognition, p. 194-7, 2004
Cytokine detection by antibody-based proximity ligation
Part of Proceedings of the National Academy of Sciences of the United States of America, p. 8420-4, 2004
Circle-to-circle amplification for precise and sensitive DNA analysis.
Part of Proc Natl Acad Sci U S A, p. 4548-53, 2004
Part of Nat Methods, p. 227-232, 2004
Oligonucleotide ligation assay
Part of Methods in Molecular Biology, p. 215-28, 2003
Parallel gene analysis with allele-specific padlock probes and tag microarrays
Part of Nucleic Acids Research, 2003
Padlock and proximity probes for in situ and array-based analyses: tools for the post genomic era
Part of Comparative and functional genomics, p. 525-30, 2003
Multiplexed genotyping with sequence-tagged molecular inversion probes
Part of Nature Biotechnology, p. 673-8, 2003
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.
Part of Genes Dev, p. 1835-40, 2003
Protein detection using proximity-dependent DNA ligation assays
Part of Nature Biotechnology, p. 473-477, 2002
A distinct Th1 immune response precedes the described Th2 response in Islet xenograft rejection
Part of Diabetes, p. 79-86, 2002
PCR-generated padlock probes detect single nucleotide variation in genomic DNA
Part of Nucleic Acids Research, 2000
X-linked recessive panhypopituitarism associated with a regional duplication in Xq25-q26
Part of American Journal of Human Genetics, p. 910-916, 1997
Part of Genomics, p. 159-162, 1995
Articles, review/survey
Molecular tools to monitor health and disease - and lucky coincidences
Part of Upsala Journal of Medical Sciences, 2022
- DOI for Molecular tools to monitor health and disease - and lucky coincidences
- Download full text (pdf) of Molecular tools to monitor health and disease - and lucky coincidences
Cancer diagnostics based on plasma protein biomarkers: hard times but great expectations
Part of Molecular Oncology, p. 1715-1726, 2021
- DOI for Cancer diagnostics based on plasma protein biomarkers: hard times but great expectations
- Download full text (pdf) of Cancer diagnostics based on plasma protein biomarkers: hard times but great expectations
A myopic perspective on the future of protein diagnostics
Part of New Biotechnology, p. 14-18, 2018
- DOI for A myopic perspective on the future of protein diagnostics
- Download full text (pdf) of A myopic perspective on the future of protein diagnostics
Part of Current Protocol in Cytometry, 2017
Close Encounters: Probing Proximal Proteins in Live or Fixed Cells
Part of TIBS -Trends in Biochemical Sciences. Regular ed., p. 504-515, 2017
Protein biomarker validation via proximity ligation assays
Part of Biochimica et Biophysica Acta - Proteins and Proteomics, p. 933-939, 2014
DNA-assisted protein detection technologies
Part of Expert Review of Proteomics, p. 21-32, 2012
Molecular tools for companion diagnostics
Part of New Biotechnology, p. 634-640, 2012
Part of Journal of Internal Medicine, p. 232-245, 2010
Analysis of Genes, Transcripts, and Proteins via DNA Ligation
Part of Annual review of analytical chemistry, p. 215-239, 2009
Part of Läkartidningen, p. 345-6, 2008
Proximity ligation assays for sensitive and specific protein analyses.
Part of Anal Biochem, p. 2-9, 2005
Chapters in book
Part of Molecular Diagnostics (Third Edition), p. 219-231, Academia Press, 2017
Part of Molecular Diagnostics, p. 299-306, Elsevier/Academic Press, 2010
Proximity ligation: a specific and versatile tool for the proteomic era.
Part of Genet Eng (N Y)., p. 190, Springer, 2007
Detection techniques for single nucleotide polymorphisms.
Part of Nucleic acid testing in human disease, p. 139-169, CRC, 2006
Emerging tools for dissecting complex disease.
Part of The hereditary basis of rheumatic diseases, p. 107-117, Birkhäuser Verlag, 2006
Ligase-mediated molecular analyses
Part of Encyclopedia of molecular biology, p. 179-193, VCH Publishers, 2004
Conference papers
Amplified Single Molecule Detection in a Thermoplastic Microfluidic System
Part of Poster at microTAS-2005 October 9-13, Boston, USA, 2005
Part of Oral at microTAS-2004 conference, Lund, Sweden, 2004
Manuscripts (preprints)
Sensitive Measurement of Cellular Drug-Target Engagement Using Multiplex Proximity Extension Assays
Multiplex digital enumeration of circular DNA molecules on solid supports
Surface protein profiles of extracellular vesicles reveal SARS-CoV-2 infection
Highly selective in situ detection of mutant transcripts with gap-fill padlock probes and superRCA
Target Engagement-Mediated Amplification for Monitoring Drug-Target Interactions in Situ