Sherry Mowbray

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI for Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
• Download full text (pdf) of Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Synthesis and kinetic evaluation of phosphomimetic inhibitors targeting type B ribose-5-phosphate isomerase from Mycobacterium tuberculosis

Courtiol-Legourd, Stephanie; Mariano, Sandrine; Foret, Johanna; Roos, Annette K. et al.

Part of Bioorganic & Medicinal Chemistry Letters, 2024

• DOI for Synthesis and kinetic evaluation of phosphomimetic inhibitors targeting type B ribose-5-phosphate isomerase from Mycobacterium tuberculosis

Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Benediktsdottir, Andrea; Sooriyaarachchi, Sanjeewani; Cao, Sha; Ottosson, Nina E. et al.

Part of European Journal of Medicinal Chemistry, 2024

• DOI for Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
• Download full text (pdf) of Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Bacterial type I signal peptidase inhibitors-Optimized hits from nature

Szalaj, Natalia; Benediktsdottir, Andrea; Rusin, Dominika; Karlén, Anders et al.

Part of European Journal of Medicinal Chemistry, 2022

• DOI for Bacterial type I signal peptidase inhibitors-Optimized hits from nature

Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Lu, Lu; Åkerbladh, Linda; Ahmad, Shabbir; Konda, Vivek et al.

Part of ACS - Infectious Diseases, p. 482-498, 2022

• DOI for Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
• Download full text (pdf) of Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI for Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
• Download full text (pdf) of Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Synthesis and kinetic evaluation of phosphomimetic inhibitors targeting type B ribose-5-phosphate isomerase from Mycobacterium tuberculosis

Courtiol-Legourd, Stephanie; Mariano, Sandrine; Foret, Johanna; Roos, Annette K. et al.

Part of Bioorganic & Medicinal Chemistry Letters, 2024

• DOI for Synthesis and kinetic evaluation of phosphomimetic inhibitors targeting type B ribose-5-phosphate isomerase from Mycobacterium tuberculosis

Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Benediktsdottir, Andrea; Sooriyaarachchi, Sanjeewani; Cao, Sha; Ottosson, Nina E. et al.

Part of European Journal of Medicinal Chemistry, 2024

• DOI for Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
• Download full text (pdf) of Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Bacterial type I signal peptidase inhibitors-Optimized hits from nature

Szalaj, Natalia; Benediktsdottir, Andrea; Rusin, Dominika; Karlén, Anders et al.

Part of European Journal of Medicinal Chemistry, 2022

• DOI for Bacterial type I signal peptidase inhibitors-Optimized hits from nature

Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Lu, Lu; Åkerbladh, Linda; Ahmad, Shabbir; Konda, Vivek et al.

Part of ACS - Infectious Diseases, p. 482-498, 2022

• DOI for Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
• Download full text (pdf) of Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

Benediktsdottir, Andrea; Lu, Lu; Cao, Sha; Zamaratski, Edouard et al.

Part of European Journal of Medicinal Chemistry, 2021

• DOI for Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation
• Download full text (pdf) of Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Szałaj, Natalia; Lu, Lu; Benediktsdottir, Andrea; Zamaratski, Edouard et al.

Part of European Journal of Medicinal Chemistry, p. 1346-1360, 2018

• DOI for Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

De Rosa, Maria; Lu, Lu; Zamaratski, Edouard; Szałaj, Natalia et al.

Part of Bioorganic & Medicinal Chemistry, p. 897-911, 2017

• DOI for Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)
• Download full text (pdf) of Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.

Singh, Vinayak; Dhar, Neeraj; Pató, János; Kolly, Gaëlle S et al.

Part of Molecular Microbiology, p. 13-25, 2017

• DOI for Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.

Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with -Arylpropyl Analogues of Fosmidomycin

Sooriyaarachchi, Sanjeewani; Chofor, Rene; Risseeuw, Martijn D. P.; Bergfors, Terese et al.

Part of ChemMedChem, p. 2024-2036, 2016

• DOI for Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with -Arylpropyl Analogues of Fosmidomycin
• Download full text (pdf) of Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with -Arylpropyl Analogues of Fosmidomycin

Expanding the catalytic triad in epoxide hydrolases and related enzymes

Amrein, Beat A.; Bauer, Paul; Duarte, Fernanda; Janfalk Carlsson, Åsa et al.

Part of ACS Catalysis, p. 5702-5713, 2015

• DOI for Expanding the catalytic triad in epoxide hydrolases and related enzymes
• Download full text (pdf) of Expanding the catalytic triad in epoxide hydrolases and related enzymes

Synthesis and Bioactivity of beta-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase

Chofor, Rene; Sooriyaarachchi, Sanjeewani; Risseeuw, Martijn D. P.; Bergfors, Terese et al.

Part of Journal of Medicinal Chemistry, p. 2988-3001, 2015

• DOI for Synthesis and Bioactivity of beta-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase
• Download full text (pdf) of Synthesis and Bioactivity of beta-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase

Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Russo, Francesco; Gising, Johan; Åkerbladh, Linda; Roos, Annette K. et al.

Part of ChemistryOpen, p. 342-362, 2015

• DOI for Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents
• Download full text (pdf) of Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development

Hsiao, An-Shan; Haslam, Richard P.; Michaelson, Louise V.; Liao, Pan et al.

Part of Bioscience Reports, p. 865-877, 2014

• DOI for Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development
• Download full text (pdf) of Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development

DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues

Jansson, Anna; Więckowska, Anna; Björkelid, Christofer; Yahiaoui, Samir et al.

Part of Journal of Medicinal Chemistry, p. 6190-6199, 2013

• DOI for DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
• Download full text (pdf) of DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues

Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098

Björkelid, Christofer; Bergfors, Terese; Unge, Torsten; Mowbray, Sherry L. et al.

Part of Acta Crystallographica Section D, p. 134-143, 2012

• DOI for Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098
• Download full text (pdf) of Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098

Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors

Nordqvist, Anneli; Nilsson, Mikael T.; Lagerlund, Olof; Muthas, Daniel et al.

Part of MedChemComm, p. 620-626, 2012

• DOI for Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]-pyridine based Mycobacterium tuberculosis glutamine synthetase inhibitors

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

Gising, Johan; Nilsson, Mikael T; Odell, Luke R; Yahiaoui, Samir et al.

Part of Journal of Medicinal Chemistry, p. 2894-2898, 2012

• DOI for Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
• Download full text (pdf) of Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase

Andaloussi, Mounir; Henriksson, Lena M.; Wieckowska, Anna; Lindh, Martin et al.

Part of Journal of Medicinal Chemistry, p. 4964-4976, 2011

• DOI for Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase
• Download full text (pdf) of Design, Synthesis, and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose 5-Phosphate Reductoisomerase

Structural and functional studies of mycobacterial IspD enzymes

Björkelid, Christofer; Bergfors, Terese; Henriksson, Lena M.; Stern, Ana Laura et al.

Part of Acta Crystallographica Section D, p. 403-414, 2011

• DOI for Structural and functional studies of mycobacterial IspD enzymes
• Download full text (pdf) of Structural and functional studies of mycobacterial IspD enzymes

Expression and beta-glucan binding properties of Scots pine (Pinus sylvestris L.) antimicrobial protein (Sp-AMP)

Sooriyaarachchi, Sanjeewani; Jaber, Emad; Covarrubias, Adrian Suarez; Ubhayasekera, Wimal et al.

Part of Plant Molecular Biology, p. 33-45, 2011

• DOI for Expression and beta-glucan binding properties of Scots pine (Pinus sylvestris L.) antimicrobial protein (Sp-AMP)
• Download full text (pdf) of Expression and beta-glucan binding properties of Scots pine (Pinus sylvestris L.) antimicrobial protein (Sp-AMP)

Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family

Stern, Ana Laura; Naworyta, Agata; Cazzulo, Juan J.; Mowbray, Sherry L.

Part of The FEBS Journal, p. 793-808, 2011

• DOI for Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family
• Download full text (pdf) of Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family

Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors

Nordqvist, Anneli; Björkelid, Christofer; Andaloussi, Mounir; Jansson, Anna M. et al.

Part of Journal of Organic Chemistry, p. 8986-8998, 2011

• DOI for Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors
• Download full text (pdf) of Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Inhibitors

Zinc ions bind to and inhibit activated protein C

Zhu, Tianqing; Ubhayasekera, Wimal; Nickolaus, Noëlle; Sun, Wei et al.

Part of Thrombosis and Haemostasis, p. 544-553, 2010

• DOI for Zinc ions bind to and inhibit activated protein C
• Download full text (pdf) of Zinc ions bind to and inhibit activated protein C

Conformational Changes and Ligand Recognition of Escherichia coli d-Xylose Binding Protein Revealed

Sooriyaarachchi, Sanjeewani; Ubhayasekera, Wimal; Park, Chankyu; Mowbray, Sherry

Part of Journal of Molecular Biology, p. 657-668, 2010

• DOI for Conformational Changes and Ligand Recognition of Escherichia coli d-Xylose Binding Protein Revealed
• Download full text (pdf) of Conformational Changes and Ligand Recognition of Escherichia coli d-Xylose Binding Protein Revealed

Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors

Nilsson, Mikael T.; Krajewski, Wojciech W.; Srinivasa, Bachally R.; Yahiaoui, Samir et al.

Part of Journal of Molecular Biology, p. 504-513, 2009

• DOI for Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors
• Download full text (pdf) of Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors

Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c

Carta, Fabrizio; Maresca, Alfonso; Covarrubias, Adrian Suarez; Mowbray, S.L. et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 6649-6654, 2009

• DOI for Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c

Competitive inhibitors of type B ribose 5-phosphate isomerases: design, synthesis and kinetic evaluation of new D-allose and D-allulose 6-phosphate derivatives

Mariano, Sandrine; Roos, Annette K.; Mowbray, Sherry L.; Salmon, Laurent

Part of Carbohydrate Research, p. 869-880, 2009

• DOI for Competitive inhibitors of type B ribose 5-phosphate isomerases: design, synthesis and kinetic evaluation of new D-allose and D-allulose 6-phosphate derivatives

The first crystal structures of a family 19 class IV chitinase: the enzyme from Norway spruce

Ubhayasekera, Wimal; Rawat, Reetika; Ho, Sharon Wing Tak; Wiweger, Malgorzata et al.

Part of Plant Molecular Biology, p. 277-289, 2009

• DOI for The first crystal structures of a family 19 class IV chitinase: the enzyme from Norway spruce
• Download full text (pdf) of The first crystal structures of a family 19 class IV chitinase: the enzyme from Norway spruce

X-ray structure of glucose/galactose receptor from Salmonella typhimurium in complex with the physiological ligand, (2R)-glyceryl-β-d- galactopyranoside

Sooriyaarachchi, Sanjeewani; Ubhayasekera, Wimal; Boos, Winfried; Mowbray, Sherry

Part of The FEBS Journal, p. 2116-2124, 2009

• DOI for X-ray structure of glucose/galactose receptor from Salmonella typhimurium in complex with the physiological ligand, (2R)-glyceryl-β-d- galactopyranoside

Removal of distal protein-water hydrogen bonds in a plant epoxide hydrolase increases catalytic turnover but decreases thermostability

Thomaeus, Ann; Naworyta, Agata; Mowbray, Sherry L.; Widersten, Mikael

Part of Protein Science, p. 1275-1284, 2008

• DOI for Removal of distal protein-water hydrogen bonds in a plant epoxide hydrolase increases catalytic turnover but decreases thermostability
• Download full text (pdf) of Removal of distal protein-water hydrogen bonds in a plant epoxide hydrolase increases catalytic turnover but decreases thermostability

X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation

Ericsson, Daniel J.; Kasrayan, Alex; Johansson, Patrik; Bergfors, Terese et al.

Part of Journal of Molecular Biology, p. 109-119, 2008

• DOI for X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation
• Download full text (pdf) of X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation

Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design

Krajewski, Wojciech W.; Collins, Ruairi; Holmberg-Schiavone, Lovisa; Jones, T. Alwyn et al.

Part of Journal of Molecular Biology, p. 217-228, 2008

• DOI for Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design
• Download full text (pdf) of Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design

Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery

Nordqvist, Anneli; Nilsson, Mikael T.; Röttger, Svenja; Odell, Luke R. et al.

Part of Bioorganic & Medicinal Chemistry, p. 5501-5513, 2008

• DOI for Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery
• Download full text (pdf) of Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery

Structural, biochemical and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis

Covarrubias, Adrian Suarez; Högbom, Martin; Bergfors, Terese; Carroll, Paul et al.

Part of Journal of Molecular Biology, p. 622-633, 2008

• DOI for Structural, biochemical and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis
• Download full text (pdf) of Structural, biochemical and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis

D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not

Roos, Annette K.; Mariano, Sandrine; Kowalinski, Eva; Salmon, Laurent et al.

Part of Journal of Molecular Biology, p. 667-679, 2008

• DOI for D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not
• Download full text (pdf) of D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not

Crystal structures of a family 19 chitinase from Brassica juncea show flexibility of binding cleft loops

Ubhayasekera, Wimal; Tang, Ce Mun; Ho, Sharon W. T.; Berglund, Gunnar et al.

Part of The FEBS Journal, p. 3695-3703, 2007

• DOI for Crystal structures of a family 19 chitinase from Brassica juncea show flexibility of binding cleft loops

Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis

Henriksson, Lena M.; Unge, Torsten; Carlsson, Jens; Åqvist, Johan et al.

Part of Journal of Biological Chemistry, p. 19905-19916, 2007

• DOI for Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis

Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase

Lagerlund, Olof; Odell, Luke R.; Mowbray, Sherry L.; Nilsson, Mikael T. et al.

Part of Combinatorial chemistry & high throughput screening, p. 783-789, 2007

• DOI for Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase

The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target.

Henriksson, Lena M; Björkelid, Christofer; Mowbray, Sherry L; Unge, Torsten

Part of Acta Crystallogr D Biol Crystallogr, p. 807-13, 2006

X-ray structure of potato epoxide hydrolase sheds light on its substrate specificity

Mowbray, Sherry L.; Elfström, Lisa; Ahlgren, Kerstin; Andersson, Evalena et al.

Part of Protein Science, p. 1628-1637, 2006

• DOI for X-ray structure of potato epoxide hydrolase sheds light on its substrate specificity

The 1.9 Å resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target

Henriksson, Lena M.; Björkelid, Christofer; Mowbray, Sherry L.; Unge, Torsten

Part of Acta Crystallogr. Section D Biol. Crystallogr., p. 807-813, 2006

Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights

Krajewski, Wojciech W; Jones, T Alwyn; Mowbray, Sherry L

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 10499-10504, 2005

• DOI for Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights

Structure and function of carbonic anhydrases from Mycobacterium tuberculosis.

Suarez Covarrubias, Adrian; Larsson, Anna M.; Högbom, Martin; Lindberg, Jimmy et al.

Part of J Biol Chem, p. 18782-9, 2005

Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights

Krajewski, Wojciech W.; Jones, T. Alwyn; Mowbray, Sherry L.

Part of Proc. Natl. Acad. Sci. USA, p. 10499-10504, 2005

Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis

Johansson, Patrik; Unge, Torsten; Cronin, Annette; Arand, Michael et al.

Part of J Mol Biol, p. 1048-56, 2005

Competitive inhibitors of Mycobacterium tuberculosis ribose-5-phosphate isomerase

Roos, Annette K; Burgos, Emmanuel; Ericsson, Daniel J; Salmon, Laurent et al.

Part of J Biol Chem, p. 6416-22, 2005

Synthesis of 5-deoxy-5-phospho-D-ribonohydroxamic acid : a new competitive and selective inhibitor of type b ribose-5-phosphate isomerase from Mycobacterium tuberculosis

Burgos, Emmanuel; Roos, Annette K.; Mowbray, Sherry L.; Salmon, Laurent

Part of Tetrahedron letters, p. 3691-3694, 2005

X-ray structures of the maltose-maltodextrin binding protein of the thermoacidophilic bacterium Alicyclobacillus acidocaldarius provide insight into acid stability of proteins

Schäfer, Karsten; Magnusson, Ulrika; Scheffel, Frank; Schiefner, André et al.

Part of Journal of Molecular Cell Biology, p. 261-274, 2004

• DOI for X-ray structures of the maltose-maltodextrin binding protein of the thermoacidophilic bacterium Alicyclobacillus acidocaldarius provide insight into acid stability of proteins

X-ray structures of the leucine-binding protein illustrate conformational changes and the basis of ligand specificity.

Magnusson, Ulrika; Salopek-Sondi, Branka; Luck, Linda A; Mowbray, Sherry L

Part of J Biol Chem, p. 8747-52, 2004

Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site

Roos, Annette; Andersson, Evalena; Bergfors, Terese; Jacobsson, Micael et al.

Part of Journal of Molecular Biology, p. 799-809, 2004

Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site.

Roos, Annette K; Andersson, C Evalena; Bergfors, Terese; Jacobsson, Micael et al.

Part of J Mol Biol, p. 799-809, 2004

X-ray structure of peptidyl-prolyl cis-trans isomerase A from Mycobacterium tuberculosis.

Henriksson, Lena M; Johansson, Patrik; Unge, Torsten; Mowbray, Sherry L

Part of Eur J Biochem, p. 4107-13, 2004

Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle

Zhang, Rong guang; Andersson, C Evalena; Savchenko, Alexei; Skarina, Tatiana et al.

Part of Structure, p. 31-42, 2003

• DOI for Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle

The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction

Zhang, Rong-Guang; Andersson, C Evalena; Skarina, Tatiana; Evdokimova, Elena et al.

Part of Journal of Molecular Biology, 2003

• DOI for The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction

Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site.

Arand, Michael; Hallberg, B Martin; Zou, Jinyu; Bergfors, Terese et al.

Part of EMBO Journal, p. 2583-2592, 2003

• DOI for Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site.

The telltale structures of epoxide hydrolases

Arand, M.; Cronin, A; Oesch, F; Mowbray, Sherry L et al.

Part of Drug metabolism reviews (Softcover ed.), p. 365-383, 2003

• DOI for The telltale structures of epoxide hydrolases

A missense mutation in ftsZ differentially affects vegetative and developmentally controlled cell division in Streptomyces coelicolor

Grantcharova, N.; Ubhayasekera, W.; Mowbray, S.L.; McCormick, J. R. et al.

Part of Molecular Microbiology, p. 645-656, 2003

Activation of Ribokinase by Monovalent Cations

Andersson, C. Evalena; Mowbray, Sherry L.

Part of Journal of Molecular Biology, p. 409-419, 2002

• DOI for Activation of Ribokinase by Monovalent Cations

Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1

Persson, Camilla; Engström, Ulla; Mowbray, Sherry; Östman, Arne

Part of FEBS Letters, p. 27-31, 2002

• DOI for Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1

Hinge-bending motion of D-allose-binding protein from Escherichia coli

Magnusson, Ulrika; Chaudhuri, Barnali Neel; Ko, Junsang; Park, Chankyu et al.

Part of J Biol Chem, p. 14077-84, 2002

Structure of Aspergillus niger epoxide hydrolase at 1.8A resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolyases

Zou, J; Hallberg, BM; Bergfors, T; Oesch, F et al.

Part of Structure, p. 111-122, 2000

Induced fit on sugar binding activates ribokinase

Sigrell, JA; Cameron, AD; Mowbray, SL

Part of JOURNAL OF MOLECULAR BIOLOGY, p. 1009-1018, 1999

Structure of D-allose binding protein from Escherichia coli bound to D-allose at 1.8 angstrom resolution

Chaudhuri, B.N.; Ko, J; Park, C; Jones, T.A. et al.

Part of JOURNAL OF MOLECULAR BIOLOGY, p. 1519-1531, 1999

Conformational changes of ribose-binding protein and two related repressors are tailored to fit the functional need

Mowbray, SL; Bjorkman, AJ

Part of JOURNAL OF MOLECULAR BIOLOGY, p. 487-499, 1999

Errors and reproducibility in electron-density map interpretation

Mowbray, SL; Helgstrand, C; Sigrell, JA; Cameron, AD et al.

Part of ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, p. 1309-1319, 1999

Structure of Escherichia coli ribokinase in complex with ribose and dinucleotide determined to 1.8 angstrom resolution: insights into a new family of kinase structures

Sigrell, JA; Cameron, AD; Jones, TA; Mowbray, SL

Part of STRUCTURE, p. 183-193, 1998

Purification, characterization, and crystallization of Escherichia coli ribokinase

Sigrell, JA; Cameron, AD; Jones, TA; Mowbray, SL

Part of PROTEIN SCIENCE, p. 2474-2476, 1997

Conformational changes of three periplasmic receptors for bacterial chemotaxis and transport: The maltose-, glucose/galactose- and ribose-binding proteins.

Shilton, BH; Flocco, MM; Nilsson, M; Mowbray, SL

Part of JOURNAL OF MOLECULAR BIOLOGY, p. 350-363, 1996

Sugar Recognition by a Glucose/Galactose Receptor: Evaluation of Binding Energetics from Molecular Dynamics Simulations

Åqvist, Johan; Mowbray, Sherry L.

Part of Journal of Biological Chemistry, p. 9978-9981, 1995

• DOI for Sugar Recognition by a Glucose/Galactose Receptor: Evaluation of Binding Energetics from Molecular Dynamics Simulations

STRANGE BEDFELLOWS - INTERACTIONS BETWEEN ACIDIC SIDE-CHAINS IN PROTEINS

FLOCCO, MM; MOWBRAY, SL

Part of JOURNAL OF MOLECULAR BIOLOGY, p. 96-105, 1995

C-ALPHA-BASED TORSION ANGLES - A SIMPLE TOOL TO ANALYZE PROTEIN CONFORMATIONAL-CHANGES

FLOCCO, MM; MOWBRAY, SL

Part of PROTEIN SCIENCE, p. 2118-2122, 1995

Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis

Mowbray, Sherry L; Kathiravan, Muthu K; Pandey, Abhishek A; Odell, Luke R

Part of Molecules, p. 13161-13176, 2014

• DOI for Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis
• Download full text (pdf) of Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis

Directed Evolution of an Enantioselective Epoxide Hydrolase: Uncovering the Source of Enantioselectivity at Each Evolutionary Stage

Reetz, Manfred T.; Bocola, Marco; Wang, Li-Wen; Sanchis, Joaquin et al.

Part of Journal of the American Chemical Society, p. 7334-7343, 2009

• DOI for Directed Evolution of an Enantioselective Epoxide Hydrolase: Uncovering the Source of Enantioselectivity at Each Evolutionary Stage
• Download full text (pdf) of Directed Evolution of an Enantioselective Epoxide Hydrolase: Uncovering the Source of Enantioselectivity at Each Evolutionary Stage

Specificity and Activity of Escherichia coli Ribokinase

Andersson, C. Evalena; Simon, Jill A.; Cameron, Alexander D.; Mowbray, Sherry L.

Specificity and Activity of Escherichia coli Ribokinase

Andersson, C. Evalena; Simon, Jill A.; Cameron, Alexander D.; Mowbray, Sherry L.

Ribose-5-phosphate isomerase B from Escerichia coli is also a functional allose-6-phosphate isomerase while the Mycobacterium tuberculosis enzyme is not

Roos, Annette K.; Mariano, Sandrine; Kowalinski, Eva; Salmon, Laurent et al.

X-ray structures of the leucine-binding protein illustrate conformational changes, as well as ligand specificity

Magnusson, Ulrika; Luck, Linda A.; Mowbray, Sherry L.

Structure and biochemical function studies of Mycobacterium tuberculosis essential protein Rv3778c

Suarez Covarrubias, Adrian; Larsson, Anna M.; Bergfors, Terese; Jones, T. Alwyn et al.

The 3'-DNA phosphatase AtZDP is present in a high molecular weight protein complex, able to repair gapped DNA with a 3' phosphate group

Valsecchi, Isabel; Wernersson, Jonny; Ubhayasekera, Wimal; Jemth, Per et al.

MEPicides: α,β-Unsaturated Fosmidomycin N-acyl Analogsas inhibitors that selectively target DXR from Plasmodium falciparum, the deadliest causative parasite of human Malaria

Lu, Lu; Wang, Xu; Edwards, Rachel L.; Sooriyaarachchi, Sanjeewani et al.

Chemotaxis receptors: A progress report on structure and function

Mowbray, SL; Sandgren, MOJ

Part of JOURNAL OF STRUCTURAL BIOLOGY, p. 257-275, 1998