Research projects in Globisch Group

We are an international research group with focus on the development of new Chemical Biology-based methodologies to improve the analysis of small molecule metabolites in biological samples. These new methodologies are aimed at enhancing the scope of metabolomics-based research. In our multidisciplinary research we work at the interface of Chemistry and Biology with a combination of Organic Chemistry, Chemical Biology techniques, Biochemistry, mass spectrometric analysis of metabolites, and metabolomics. The discovery of specific early-stage biomarkers, new drug targets and the development of new therapeutic interventions are crucial for disease prevention and management towards personalized medicine.

Overview of the research in the Globisch group. The figure contains schematic images of a variety of methods: organic synthesis of novel metabolites, microbiome-host investigations, sulfatom analysis, glucoronic acid analysis, global metabolomics, structural validation of metabolites, chemoselective probes, and quantitative chemoselective metabolomics (Quant-SCHEMA).

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