Lanekoff Group
Innovative mass spectrometric tools to decipher the chemistry of biological systems
The function of biological systems depends on intricate chemical interactions where the molecular structure is crucial. In our group, we develop innovative mass spectrometric tools that enable small molecule characterization with isomeric precision from minute biological material, down to individual cells. Our tools include pneumatically assisted nanospray desorption electrospray ionization (PA nano-DESI) for imaging of thin tissue sections, the direct infusion probe (DIP) for molecular profiling of minute (µL) sample volumes, tapered PA nano-DESI for global chemical analysis of single cells, and surface sampling capillary electrophoresis for spatial metabolomics with isomeric resolution. Additionally, we develop data handling tools to visualize and assess our unique data formats. We also employ creative and strategic approaches for quantifying the detected analytes, tailoring solvents and pushing the mass spectrometer performances beyond the state-of-the-art.
Group members
Publications
Part of International Journal of Molecular Sciences, 2024
- DOI for Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
- Download full text (pdf) of Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome: A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility
Part of Talanta Open, 2024
Part of Metabolites, 2024
- DOI for Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
- Download full text (pdf) of Online Direct Infusion Mass Spectrometry of Liquid-Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
Part of Electrophoresis, p. 387-394, 2023
Part of Analytical Chemistry, p. 11589-11595, 2023
Part of Journal of the American Society for Mass Spectrometry, p. 2341-2349, 2023
Part of Analytical Chemistry, p. 17843-17850, 2023
Part of Journal of the American Society for Mass Spectrometry, p. 2518-2524, 2023
Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
Part of Metabolites, 2023
Part of Scientific Reports, 2023
- DOI for Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics
- Download full text (pdf) of Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics
Single cell metabolism: current and future trends
Part of Metabolomics, 2022
Single-cell metabolomics: where are we and where are we going?
Part of Current Opinion in Biotechnology, 2022
Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization
Part of Analytical and Bioanalytical Chemistry, p. 7473-7482, 2022
Part of Vietnam Journal of Food Control, p. 89-103, 2022
Part of Analytical Chemistry, p. 2391-2398, 2022
Part of Environmental Science and Technology, p. 3096-3105, 2022
A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
Part of Analytical Chemistry, p. 12875-12883, 2022
Part of Analytical and Bioanalytical Chemistry, p. 2735-2745, 2021
Part of Communications Biology, 2021
PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
Part of Organs-on-a-Chip, 2020
Part of Journal of the American Society for Mass Spectrometry, p. 2479-2487, 2020
Advances in mass spectrometry based single-cell metabolomics
Part of The Analyst, p. 782-793, 2019
Part of International Journal of Mass Spectrometry, p. 49-57, 2019
Spatially Defined Surface Sampling Capillary Electrophoresis Mass Spectrometry
Part of Analytical Chemistry, p. 7819-7827, 2019
Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging
Part of Analytical and Bioanalytical Chemistry, p. 2809-2816, 2019
Part of Encyclopedia of Analytical Chemistry, Wiley-VCH Verlagsgesellschaft, 2018
Improving the biocompatibility of PDMS by improving its curing time and temperature
2018
Quantitative Mass Spectrometry Imaging of Molecules in Biological Systems
Part of Advances In Chromatography, Vol 54, p. 43-72, CRC Press, 2018
Oversampling To Improve Spatial Resolution for Liquid Extraction Mass Spectrometry Imaging
Part of Analytical Chemistry, p. 2451-2455, 2018
Tailoring the biocompatibility of the elastomer PDMS for on-chip applications
2018
Part of Analytical Chemistry, p. 7246-7252, 2018
Profiling and quantifying endogenous molecules in single cells using nano-DESI MS
Part of The Analyst, p. 3639-3647, 2017
Part of The Analyst, p. 3424-3431, 2017
Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS
Part of Journal of Analytical Methods in Chemistry, 2016
Part of The Analyst, p. 3686-3695, 2016
Ambient Mass Spectrometry Imaging Using Direct Liquid Extraction Techniques
Part of Analytical Chemistry, p. 52-73, 2016
Part of Scientific Reports, 2016
PACAP suppresses dry eye signs by stimulating tear secretion
Part of Nature Communications, 2016
Part of Analytical and Bioanalytical Chemistry, p. 2063-2071, 2015
Towards Adaptive, Streaming Analysis of X-ray Tomography Data
Part of Synchrotron Radiation News, p. 10-14, 2015
Part of Methods in molecular biology, p. 99-106, Springer, 2015
Part of Analytical Chemistry, p. 1872-80, 2014
Matrix effects in biological mass spectrometry imaging: identification and compensation
Part of The Analyst, p. 3528-3532, 2014
Part of Analytical Chemistry, p. 9596-9603, 2013
Part of The Analyst, p. 1971-1978, 2013
Part of Analytical Chemistry, p. 882-889, 2013
C60-ToF SIMS imaging of frozen hydrated HeLa cells
Part of Surface and Interface Analysis, p. 302-304, 2013
Mass spectrometry imaging of freeze-dried membrane phospholipids of dividing Tetrahymena pyriformis
Part of Surface and Interface Analysis, p. 211-214, 2013
Velo and REXAN – Integrated Data Management and High Speed Analysis for Experimental Facilities
Part of Proceeding IEEE International Conference on E-Science 2012, p. 1-9, 2012
Part of Analytical Chemistry, p. 8351-8356, 2012