Dyrager Group

Vials containing solutions that fluoresce in blue and yellow against a black background.

Photo: Susanne Doloczki

Targeting hypoxia in cancer therapy and diagnosis

Our group works on the design and synthesis of “brilliant” (fluorescent) compounds as molecular probes for cell imaging applications. We are mainly interested in compounds that can accumulate specifically in hypoxic cancer cells and thus be used as diagnostic tools in the field of oncology. Our research is multidisciplinary and includes organic synthesis, photophysics, enzymatic reactions and cell studies.

Group members

Research leader: Christine Dyrager

Publications

Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma

Sainero-Alcolado, Lourdes; Garde-Lapido, Elisa; Snaebjörnsson, Marteinn Thor; Schoch, Sarah et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2024
- DOI for Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma
- Download full text (pdf) of Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma
Derivatization of 2,1,3-Benzothiadiazole via Regioselective C–H Functionalization and Aryne Reactivity

Kunz, Susanna; Barnå, Fredrik; Posada Urrutia, Mauricio; Ingner, Fredric J. L. et al.

Part of Journal of Organic Chemistry, p. 6138-6148, 2024
- DOI for Derivatization of 2,1,3-Benzothiadiazole via Regioselective C–H Functionalization and Aryne Reactivity
- Download full text (pdf) of Derivatization of 2,1,3-Benzothiadiazole via Regioselective C–H Functionalization and Aryne Reactivity
Tuning the Emission Properties of 2,1,3‐Benzothiadiazoles via Regioselective Substitution

Posada Urrutia, Mauricio; Dyrager, Christine

Part of Chemistry - A European Journal, 2024
- DOI for Tuning the Emission Properties of 2,1,3‐Benzothiadiazoles via Regioselective Substitution
- Download full text (pdf) of Tuning the Emission Properties of 2,1,3‐Benzothiadiazoles via Regioselective Substitution
Access to long-lived room temperature phosphorescence through auration of 2,1,3-benzothiadiazole

Posada Urrutia, Mauricio; Kaul, Nidhi; Kaper, Tobias; Hurrell, Dustin et al.

Part of Dalton Transactions, p. 5658-5664, 2024
- DOI for Access to long-lived room temperature phosphorescence through auration of 2,1,3-benzothiadiazole
- Download full text (pdf) of Access to long-lived room temperature phosphorescence through auration of 2,1,3-benzothiadiazole
Photoinduced ring‐opening and phototoxicity of an indolin‐3‐one derivative

Doloczki, Susanne; Kern, Christoph; Holmberg Olausson, Karl; Swartling, Fredrik J. et al.

Part of Chemistry - A European Journal, 2023
- DOI for Photoinduced ring‐opening and phototoxicity of an indolin‐3‐one derivative
- Download full text (pdf) of Photoinduced ring‐opening and phototoxicity of an indolin‐3‐one derivative
An Indolin-3-imine Photobase and pH Sensitive Fluorophore

Doloczki, Susanne; Kern, Christoph; Holmberg, Karl O.; Zhao, Miao et al.

Part of ChemPhotoChem, 2023
- DOI for An Indolin-3-imine Photobase and pH Sensitive Fluorophore
- Download full text (pdf) of An Indolin-3-imine Photobase and pH Sensitive Fluorophore
Photophysical characterization and fluorescence cell imaging applications of 4-N-substituted benzothiadiazoles

Doloczki, Susanne; Holmberg, Karl O.; Galván, Ignacio Fdez.; Swartling, Fredrik J. et al.

Part of RSC Advances, p. 14544-14550, 2022
- DOI for Photophysical characterization and fluorescence cell imaging applications of 4-N-substituted benzothiadiazoles
- Download full text (pdf) of Photophysical characterization and fluorescence cell imaging applications of 4-N-substituted benzothiadiazoles
Photophysical Characteristics of Polarity-Sensitive and Lipid Droplet-Specific Phenylbenzothiadiazoles

Colas, Kilian; Doloczki, Susanne; Kesidou, Aikaterina; Sainero-Alcolado, Lourdes et al.

Part of ChemPhotoChem, p. 632-643, 2021
- DOI for Photophysical Characteristics of Polarity-Sensitive and Lipid Droplet-Specific Phenylbenzothiadiazoles
- Download full text (pdf) of Photophysical Characteristics of Polarity-Sensitive and Lipid Droplet-Specific Phenylbenzothiadiazoles
Prevalent Bioimaging Scaffolds: Synthesis, Photophysical Properties and Applications

Colas, Kilian; Doloczki, Susanne; Posada Urrutia, Mauricio; Dyrager, Christine

Part of European Journal of Organic Chemistry, p. 2133-2144, 2021
- DOI for Prevalent Bioimaging Scaffolds: Synthesis, Photophysical Properties and Applications
- Download full text (pdf) of Prevalent Bioimaging Scaffolds: Synthesis, Photophysical Properties and Applications
Indolylbenzothiadiazoles as highly tunable fluorophores for imaging lipid droplet accumulation in astrocytes and glioblastoma cells

Colas, Kilian; Holmberg Olausson, Karl; Chiang, Linus; Doloczki, Susanne et al.

Part of RSC Advances, p. 23960-23967, 2021
- DOI for Indolylbenzothiadiazoles as highly tunable fluorophores for imaging lipid droplet accumulation in astrocytes and glioblastoma cells
- Download full text (pdf) of Indolylbenzothiadiazoles as highly tunable fluorophores for imaging lipid droplet accumulation in astrocytes and glioblastoma cells
Mechanochemical synthesis of (hetero)aryl Au(i) complexes

Ingner, Fredric; Giustra, Zachary X.; Novosedlik, Sebastian; Orthaber, Andreas et al.

Part of Green Chemistry, p. 5648-5655, 2020
- DOI for Mechanochemical synthesis of (hetero)aryl Au(i) complexes
- Download full text (pdf) of Mechanochemical synthesis of (hetero)aryl Au(i) complexes