Pharmacognosy
Description
In addition to the possibility to discover new drug candidates for drug development, bioactive natural products have potential as pharmacological tools, intermediates, or templates for synthesis of drugs. As a multidisciplinary division we conduct extensive national and international research collaborations in e.g. clinical pharmacology, marine chemical ecology, systematic botany and structural biology.
Our research represents a modernization and renewal of a venerable proven science, Pharmacognosy. With today's increased interest for environmental aspects, green chemistry, and a sustainable use of natural products, this renewal could have a strategic position in bridging chemistry and biology.
The ongoing projects are focused on chemistry and biology of ultra stable proteins, methods of selection and target-finding, antifouling and antibacterial molecules from marine organisms (sponges, nemertines), anti-inflammatory and antitumor activity of natural products.
Publications
Part of PLOS ONE, 2024
- DOI for Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa
- Download full text (pdf) of Screening for antibacterial and cytotoxic activities of Sri Lankan marine sponges through microfractionation: Isolation of bromopyrrole alkaloids from Stylissa massa
The involvement of cyclotides in the heavy metal tolerance of Viola spp.
Part of Scientific Reports, 2024
Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads
Part of Biomedicines, 2023
Part of Journal of Natural Products, p. 52-65, 2023
- DOI for Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens
- Download full text (pdf) of Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens
Part of Fitoterapia, 2023
On the structures of the penduflorines from Tabernaemontana penduliflora
Part of Fitoterapia, 2023
Part of ACS Applied Materials and Interfaces, p. 24186-24196, 2023
Part of ACS Omega, p. 37116-37127, 2023
- DOI for Anti-inflammatory and Antiphytopathogenic Fungal Activity of 2,3-seco-Tirucallane Triterpenoids Meliadubins A and B from Melia dubia Cav. Barks with ChemGPS-NP and In Silico Prediction
- Download full text (pdf) of Anti-inflammatory and Antiphytopathogenic Fungal Activity of 2,3-seco-Tirucallane Triterpenoids Meliadubins A and B from Melia dubia Cav. Barks with ChemGPS-NP and In Silico Prediction
A Synthetic Cyclized Antimicrobial Peptide with Potent Effects against Drug-Resistant Skin Pathogens
Part of ACS - Infectious Diseases, p. 1056-1063, 2023
Part of Journal of Natural Products, p. 566-573, 2023
- DOI for Exploring the limits of cyanobactin macrocyclase PatGmac: Cyclization of PawS-derived peptide sunflower trypsin inhibitor-1 and cyclotide kalata B1
- Download full text (pdf) of Exploring the limits of cyanobactin macrocyclase PatGmac: Cyclization of PawS-derived peptide sunflower trypsin inhibitor-1 and cyclotide kalata B1
Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro
Part of Pharmaceutics, 2023
Epitopes displayed in a cyclic peptide scaffold bind SARS-CoV-2 antibodies
Part of ChemBioChem, 2023
Part of PLANTS, 2022
The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite
Part of Scientific Reports, 2022
Part of Cellular and Molecular Life Sciences (CMLS), 2022
Part of Journal of Natural Products, p. 215-224, 2022
Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis
Part of Journal of Internal Medicine, p. 745-763, 2022
Part of PLOS ONE, 2022
Part of Pharmaceutics, 2022
- DOI for Stability Study of Alpinia galanga Constituents and Investigation of Their Membrane Permeability by ChemGPS-NP and the Parallel Artificial Membrane Permeability Assay
- Download full text (pdf) of Stability Study of Alpinia galanga Constituents and Investigation of Their Membrane Permeability by ChemGPS-NP and the Parallel Artificial Membrane Permeability Assay
Cyclotide host-defense tailored for species and environments in violets from the Canary Islands
Part of Scientific Reports, 2021
Part of PLOS ONE, 2021
Part of Journal of Agricultural and Food Chemistry, p. 11856-11866, 2021
Functional characterization of the nemertide alpha family of peptide toxins
Part of Journal of Natural Products, p. 2121-2128, 2021
Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti
Part of Journal of Natural Products, p. 3138-3146, 2021
Part of Phytochemistry, 2021
Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates
Part of World Journal of Microbiology & Biotechnology, 2021
Part of RSC CHEMICAL BIOLOGY, p. 1682-1691, 2021
Exploring natural products-based cancer therapeutics derived from egyptian flora
Part of Journal of Ethnopharmacology, 2021
Part of Biochemistry and Biophysics Reports, 2021
Part of Frontiers in Pharmacology, 2021
Editorial: Natural Antimicrobial Peptides: Hope for New Antibiotic Lead Molecules
Part of Frontiers in Pharmacology, 2021
Recent insights into chemical and pharmacological studies of bee bread
Part of Trends in Food Science & Technology, p. 300-316, 2020
Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae)
Part of Journal of Natural Products, p. 1305-1308, 2020
Part of Journal of Systematics and Evolution, p. 103-117, 2020
The life cycle of cyclotides: biosynthesis and turnover in plant cells
Part of Plant Cell Reports, p. 1359-1367, 2020
Part of Phytochemistry Letters, p. 6-11, 2020
Part of Journal of Ethnopharmacology, 2020
- DOI for Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens
- Download full text (pdf) of Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens
Part of Molecules, 2020
Part of Frontiers in Pharmacology, 2020
Part of Frontiers in Microbiology, 2020
Part of Journal of Natural Products, p. 798-812, 2019
Marine Natural Products: A Source of Novel Anticancer Drugs
Part of Marine Drugs, 2019
Part of Toxins, 2019
Part of ACS Chemical Biology, p. 1525-1535, 2018
Part of Arthritis & Rheumatology, 2018
Peptide ion channel toxins from the bootlace worm, the longest animal on Earth
Part of Scientific Reports, 2018
Part of Frontiers in Plant Science, 2018
Part of ChemBioChem, p. 931-939, 2018
Briaviolides K-N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum
Part of Marine Drugs, 2018
Single-step purification of cyclotides using affinity chromatography
Part of Biopolymers, 2017