Extra Rudbeck seminar – Vessela Kristensen

The lecture will address BC pathophysiology integrating multi-omics data from different clinical trials, also through novel single-cells technologies to identify biomolecular signatures of responders vs. non responders and to dissect tumor heterogeneity and individual response to treatment. We will describe systems medicine approaches to integrate multiple levels of omics data on the example of clinical trials with hormonal therapy, chemotherapy and targeted treatment. Through our Horison2020 project RESCUER we may explore also organoid and primary cultures of breast tumor cells for ex vivo drugs screening of cells with certain copy number alterations and will apply mechanistic modelling to simulate in silico the treatment effects on cancer cells. This will allow to propose alternative treatment combinations, individually adjusted doses, and administration frequencies, based on in silico statistical models instructed by and validated in animal models and organoid structures. It will also discuss new biomarkers to be routinely examined in the clinic.