Early and late neuromuscular effects of botulinum toxin treatment in chronic migraine

The aim of this study is to understand which effects arise after a treatment with botulinum toxin A ("botox") in the indication migraine in injected and non-injected facial muscles. In order to understand both short-term and long-term effects of botox, we will perform analyzes both of the neuromuscular signaling, which botox directly affects, and signs of denervation, reinnervation and chronic myopathy that speak for long-term effects.