Mapping disease mechanisms in MG through characterization of the complement-mediated attack

The goal of this PhD project is to establish an in-vitro human cell model for MG of human iPSC cells and study the molecular mechanisms and signaling pathways in this model. This model enables time-course studies of the presynaptic and postsynaptic cascades of events that result in impaired neuromuscular transmission. The goals are to visualize the complement-induced attack on the muscle membrane in MG and to characterize the complement activation in MG patients.