Mechanisms underlying disturbed neuronal and neuromuscular signaling

Using a multielectrode (Mea1k) chip model consisting of 26,400 platinum electrodes, we can record extracellular postsynaptic potentials from muscle and nerve cells. We work with iPSC cell-derived motor neurons and muscle cells. In this model system, we can simulate various diseases, primarily Myasthenia Gravis (MG), to map the temporal course in the emergence of disturbed neuromuscular transmission. This enables individualized patient models.