Dissertation • Eman Ibrahim
- Date
- 16 October 2025, 09:15–13:00
- Location
- Uppsala Biomedical Centre, Lecture Hall A1:107a
- Type
- Thesis defence
- Lecturer
- Eman Ibrahim, PhD Student at the Department of Pharmacy
- Thesis author
- undefined
- Publication
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-565557
- Organiser
- Department of Pharmacy
- Contact person
- Eman Ibrahim
Eman Ibrahim, PhD student at Uppsala University's Department of Pharmacy, defends her thesis Mechanism-based pharmacometric models to improve the development and use of anticancer therapies, a work that paves new ways for Model-informed drug development.
Development of new cancer drugs remains one of the most challenging domains in pharmaceutical research. To contribute to more resource-efficient progress, Uppsala University's research environment in Pharmacokinetics and Pharmacodynamics is developing tools to predict which dosing strategy provides the most information in experimental and clinical studies and the best effect—with tolerable side effects—in clinical practice.
In her research project, Eman Ibrahim, PhD student at the Department of Pharmacy, has developed a number of frameworks where she integrates mathematical models and data from laboratory experiments, animal studies and clinical trials. In her thesis, Eman Ibrahim shows how her work provides a basis for dose optimization in drug treatment, identifies biomarkers that predict efficacy and side effects and points the way for tailored treatments.
The results that Eman Ibrahim presents add important knowledge to Model-informed drug development, improve the conditions to integrate preclinical and clinical data and, not least, strengthen the foundation for evidence-based decision making across the drug development lifecycle.
Researcher Bio
Eman Ibrahim enrolled at Uppsala University's Master's Programme in Pharmaceutical Modelling in 2017. After conducting her degree project at AstraZeneca's facility in Mölndal, Eman was in 2020 recruited as a PhD student to Professor Lena Friberg's research environment at the Department of Pharmacy