Dissertation • Kimia Hosseini
- Date
- 17 October 2025, 13:00–17:00
- Location
- BMC hall A1:111a
- Type
- Thesis defence
- Lecturer
- Kimia Hosseini, PhD Student, Department of Pharmaceutical Biosciences
- Thesis author
- undefined
- Publication
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-565703
- Organiser
- Department of Pharmaceutical Biosciences
- Contact person
- Kimia Hosseini
Kimia Hosseini, PhD student at Uppsala University's Department, defends her thesis Exploring Human Neural Stem Cells as an In Vitro Model for Evaluating Developmental Neurotoxicity, a work in which Kimia introduces an In vitro model to determine the developmental neurotoxicity effects of chemicals on the central nervous system.
As we are exposed to an increasing number of chemicals, the need grows for effective tools to determine which substances put us at risk to develop neurodevelopmental disorders. Currently, researchers and regulatory authorities are referred to cost-ineffective animal-based approaches of limited biological relevance to assess how chemicals affect the human central nervous system.
In her research project, Kimia Hosseini, PhD Student at the Department of Pharmaceutical Biosciences, has developed an in vitro model using human embryonic stem cells that were matured into neuron cells – a tool that enables controlled studies of human brain development under the influence of chemicals.
In her PhD thesis, Kimia Hosseini also describes how this in vitro model enabled identification of possible links between drugs that can be prescribed to pregnant women and their potential effects on the fetus.
Researcher Bio
Kimia Hosseini is a registered pharmacist. During master's studies at Uppsala University, she conducted her degree project with a focus on cells at the Department of Pharmacy. In 2018, Kimia Hosseini was recruited to Professor Robert Fredriksson's research environment in Pharmacology.
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In vitro model identifies chemicals that can cause neurodevelopmental disorders