Important scientific progress signed SweDeliver

SweDeliver publiceringar 2025

Throughout the scientific season Xiguo He, Julia Parlow, Marilena Marinaki and several other researchers at SweDeliver are publishing new results that add valuable knowledge to ongoing research and current challenges in parenteral, oral and aerosol drug delivery.

In her article Liquid crystal nanoparticles for oral combination antibiotic therapies: A strategy towards protecting commensal gut bacteria during treatment, Xiguo He, PhD student at the SweDeliver Oral drug delivery Work package, presents advances in the ongoing project aiming to enable new formulations for oral administration of antibiotics in order to treat systemic infections and reduce risks during medical procedures.

The work represents a proof of concept for the early-stage development of antibiotic-loaded liquid crystal nanoparticles (LCNP) to treat systemic infection via oral administration, opening opportunities for combination antibiotic therapies. The article, co-authored by Center Director Christel Bergström and Madlen Hubert, researcher at Uppsala University’s Department of Pharmacy, is avaliable in the journal Journal of Colloid and Interface Science, volume 678, 2025.

Julia Parlow, doktorand vid Institutionen för läkemedelskemi

Julia Parlow, PhD student at the Department of Medicinal Chemistry

Julia Parlow, PhD student at the SweDeliver Parenteral drug delivery Work package, has published the article FRAP analysis of peptide diffusion in extracellular matrix mimetic hydrogels as an in vitro model for subcutaneous injection in the journal International Journal of Pharmaceutics, volume 664, 2024.

In this article, Julia Parlow shows – in collaboration with, among others, Per Hansson and Johan Gråsjö – that a specific Fluorescence recovery after photobleaching (FRAP) method provides useful information of peptides’ interactions and transport properties in hydrogel networks, giving insight into the mechanisms affecting absorption of drug compounds after subcutaneous injection.

Marilena Marinaki, PhD student at the SweDeliver Aerosol drug delivery Work package, demonstrates in her article Mechanical characterization of tablets using post compression in-die cyclic loading why post compression in-die cyclic loading is an analytical powder compression tool that enables characterization of tablets in terms of elastic, plastic and viscoelastic deformation as well as damage.

The article is published in Powder Technology, volume 444, 2024 and co-authored by Ann-Sofie Persson and Göran Frenning at SweDeliver and Uppsala University’s Department of Pharmaceutical Biosciences.

Facts

  • SweDeliver is a national competence center in drug delivery.
  • With Uppsala University's Faculty of Pharmacy as Academic hub and 14 industrial partners, SweDeliver conducts research on parenteral, oral and pulmonary administration.

Contact

Xiguo He, PhD Student
Department of Pharmacy
Xiguo.He@farmaci.uu.se

Julia Parlow, PhD Student
Department of Medicinal Chemistry
julia.parlow@ilk.uu.se

Marilena Marinaki, PhD Student
Department of Pharmaceutical Biosciences
marilena.marinaki@farmbio.uu.se

text: Magnus Alsne, photo: Mikael Wallerstedt

FOLLOW UPPSALA UNIVERSITY ON

Uppsala University on Facebook
Uppsala University on Instagram
Uppsala University on Youtube
Uppsala University on Linkedin